Phase I clinical trial for a PCa vaccine...

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Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 12/8/2009 2:08 AM (GMT -6)   
Nope not Provenge.
Interesting read...

Wouldn't it be great!

Prostate Cancer Forum Co-Moderator

Elite Member

Date Joined Oct 2008
Total Posts : 25393
   Posted 12/8/2009 9:57 AM (GMT -6)   
Good post. Sometimes reaching into the past can produces results that were missed before. I hope with all my being, that even 5 - 10 years from now time frame, something or some method will be found to greatly help the next generation of PC guys.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out  38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - began IMRT SRT - 39 sess/72 gys ,cath #8 33 days, Cath #9 in 35 days, 12/7/9 - Cath #10 in place

Regular Member

Date Joined Aug 2009
Total Posts : 374
   Posted 12/8/2009 10:36 AM (GMT -6)   
Thanks, Tony, for the post. Persuant to your comment, David: after all my consultations prior to pulling the trigger on Robotic Prostatectomy, the prostate cancer oncologist I spoke to counseled me on not worrying about % of recurrences after RP versus brachytherapy, versus proton beam, etc. Rather he validated the process by which I arrived at my decsion, and said that if it didn't come back on me right away, that by the time it did (if it did), the playing field for treatment options would
would look different than it does today because of all the research and clinical trials. To worry and try to factor possibilities would be a statistical game of apples and oranges. So let's hope he's right for all of us who've been diagnosed and treated, as well as those who have yet to turn down this road.
Arnie in DE
Age 56 (biopsy & surgery)
PSA at Diagnosis-3.9
Biposy 8/19/08--4 of 12 cores positive; 5% involvement, Gleason 6 (3+3)
Surgery 1/26/09-DaVinci Robotic Prostatectomy at Presbyterian Medical Center/HUP-Phila, PA
Dr. David Lee
Pathology Report- Adenocarcinoma, no capsular involvement, seminal vesicles clear, lymph nodes clear, negative margins, Gleason 7 (3+4), Stage T2C, Prostate 61.8 grams, gland involvement 2-10%
Catheter removed after 8 days, totally dry at 3 months. ED issues continue, Viagra (via ADC) nightly (100mgs), VED use in earnest at 6 months. "Ball Park Frank" plumping at this point......ED at 10 months continues to improve, albeit slowly. Continued daily use of 100mg Viagra (ADC). Discontinued pump use; manual stimulation to varying states of erections; achieved penetratable erection on a couple of occasions
3 month PSA--<0.1
6 month PSA--<0.1
10 month PSA--<0.1

Veteran Member

Date Joined Jan 2007
Total Posts : 762
   Posted 12/8/2009 4:20 PM (GMT -6)   
Hi TC, how's the weather over there? (LOL!! - we are swimming here!).. sorry bad joke!

On a serious note, this is always on my mind. My stepson (husband's adult son) is now 32. We are both (secretly) relieved that he is well into starting his family at the moment (he and his wife have a 4 year old and 9 month old) - both girls, so no need to worry about them! He (the 32 year old) has already had a baseline done as his father (my CJ) got Pca at 49, but on examination of the previous PSA's it was too high at 45 years and should have been more closely monitored then.
Our other concern is our own son (now 9 years). He was 6 when his dad (also CJ!) got Pca. He is still into childhood things, but he knows what prostate cancer is. It has touched his life too. I will be always researching the topic for him as well as CJ therefore.
So any news of progress towards a prevention, or a vaccine, or any cure, is always music to our ears! This is a small study but sounds very promising. They really should go for the jugular and publish widely, as if the results are valid they could always extend it with funding, and someone else may take up the task and replicate other settings.

Have a lovely day Tony and thanks for sharing. If it is not to early to say this, have a safe and happy Christmas season. Lots of love to you. Lana & CJ
Creed_three - Husband 51 yrs (49 years at diagnosis)
PSA (2002) 2.1.  PSA (2006) 3.5.  1 x 5% core of 12 positive at biopsy. Open Radical Prostatectomy with nerve sparing April 2007. Gleeson 3 + 4 = 7.   Undetectable <.1 PSA since, specifically, June 2007-0.01, Oct 2007-0.02, April 2008-0.02: Oct 2008-0.03, Nov, 2008-0.02, April 2009-0.03. 

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