A question for HT guys

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Geebra
Regular Member


Date Joined May 2009
Total Posts : 476
   Posted 12/10/2009 8:22 AM (GMT -6)   
I was thinking, since my Luprone shots give me frequent hot flushes, why wouldn't they switch me to Casodex? I know the two work completely different, but when I started Casodex before my first Luprone shot. My PSA droped like a rock.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 12/10/2009 8:34 AM (GMT -6)   
Are you under the care of a uro-doc or oncologist right now? What is the psa histories thus far and with what? What doseage (duration) of Lupron are you currently given? What is the current psa reading and how often do you monitor your psa's?

This might be useful in finding some replies, perhaps. There also are drug(s) that you can take to diminish or stop the hot flashes. It is no party or disco doing the LHRH drugs(lupron-zoladex-eligard-etc.) but usually works on most patients and results vary alot which is normal for PCa issues.

dkob131
Regular Member


Date Joined Apr 2008
Total Posts : 364
   Posted 12/10/2009 9:11 AM (GMT -6)   

Geebra:  I had some serious hot flashes during my first 2 months of Lupron then began taking a Soy Ivoflavin supplement and have had very little problem since then.  Your Doc. can prescribe you meds to stop it also, they work .

 

David


 54 y.o.
 Diagnosed 4/10/08
 DRE Normal
 PSA-5.5
 Biopsy- 12 cores, 4 positive highest 4+4=8
 Bone scan, CT scan and Chest X-ray clear 4/16/08
 Urologist suggested surgery 4/16/08
 MRI on 4/24/08 clear no suggestion of lymph node   involvement.
 4/24/08 -Started on Lupron and Casodex preparing for HDRT and IMRT in late July.  This treatment will not preclude me from surgery if I change my mind.
Decide to have DaVinci surgery after another consult with surgeon.
6/19/08- DaVinci surgery at University of Washington.
6/25/08- Path report, clear margins, no noted extension
9/12/08- PSA <0.02 
12/05/08-PSA <0.02 Six months after surgery 
3/02/09-PSA <0.02 Nine months after surgery
5/02/09-PSA .10
8/17/09-PSA .21 Begin HT and set up for SRT to begin in 2 months.
 


Jim B
Regular Member


Date Joined Mar 2009
Total Posts : 45
   Posted 12/10/2009 10:03 AM (GMT -6)   
After they found the bone mets, my doc put me back on lupron with the casodex. Unfortunately, the casodex caused some increase in liver hormones so that was dropped. And David is right. check with your doc for some meds to fight the hot flashes.
Dx age 48 PSA 11.58
Biopsy Nov 04
4 of 6 specimens positive
gleason 4+5=9
Perineural invasion at two locations
40 radiation treatments Jan-Mar 05
PSA May 05 0.07
Aug 05 0.15
Feb 06 0.92
Oct 06 0.55
Sep 07 0.42
Mar 08 1.13
Aug 08 2.26
Nov 08 3.98
Jan 09 5.81
Mar 09 9.02
Bone scan in Nov 08- one spot in pelvic region 1.9cm with SUV of 11
Bone scan in Mar 09-two spots. Original now 2.5cm with SUV of 22 and 2nd spot less than 1cm with SUV of 7.8


dkob131
Regular Member


Date Joined Apr 2008
Total Posts : 364
   Posted 12/10/2009 10:14 AM (GMT -6)   

Jim B.:

I think you and I are in a small group who can't handle Casodex, the same thing happened to me.  My liver function readings went thru the roof, once I stopped the Casodex it fell right back in line.

 

David 


 54 y.o.
 Diagnosed 4/10/08
 DRE Normal
 PSA-5.5
 Biopsy- 12 cores, 4 positive highest 4+4=8
 Bone scan, CT scan and Chest X-ray clear 4/16/08
 Urologist suggested surgery 4/16/08
 MRI on 4/24/08 clear no suggestion of lymph node   involvement.
 4/24/08 -Started on Lupron and Casodex preparing for HDRT and IMRT in late July.  This treatment will not preclude me from surgery if I change my mind.
Decide to have DaVinci surgery after another consult with surgeon.
6/19/08- DaVinci surgery at University of Washington.
6/25/08- Path report, clear margins, no noted extension
9/12/08- PSA <0.02 
12/05/08-PSA <0.02 Six months after surgery 
3/02/09-PSA <0.02 Nine months after surgery
5/02/09-PSA .10
8/17/09-PSA .21 Begin HT and set up for SRT to begin in 2 months.
 


zachattack
Regular Member


Date Joined Dec 2009
Total Posts : 97
   Posted 12/10/2009 11:59 AM (GMT -6)   
Hi all.
I am on eligard and the hot flashes are sometimes pretty intense for Me. I called my doctor and he is calling in a script for me as we speak.I think the name of the med is megace.If anyone has had any dealings with this drug can you shed some light on it. thanks Zach
age 55dx 12-2008,psa at biopsy 8.6
biopsy 12/12 gleason 3+4=7
da vinci surgery 6-09 by DR. John W. Scott (my hero)
Hospital 3 days cath 7days still leaking from cough(bad lungs)
still have ed may be the hormones.
9-09 psa 2.2 hormone inj
10-09 nuclear bone scan no results yet I will have gold markers placed 12-29-09
start rad 1-10-09
organ confined
extracapsular seminal vesicle involvement
lymph node involvement


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4268
   Posted 12/10/2009 1:07 PM (GMT -6)   
Geebra,
If you are on HT you should be seeing an oncologist as he can adjust the drugs and knows haw to minimise the side affects. Casodex was given 1st to reduce flare; but it is also common to continue with Casodex while taking Lupron and also add Proscar or Adovart. The combination of all three blockers seems to be more effective in some patients and allows intermittent treatment with more time off between treatments for a better quality of life.
JT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.

JohnT

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