What is "Acinar" histologic type?

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Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 12/22/2009 2:48 PM (GMT -6)   
I was reading a post today that states a histologic type "Adenocarcinoma" while my histological type is "Acinar". We both had the same surgeon and most likely the same lab doing the pathology report.
Is there any significance to this definition? Thanks
Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 12/22/2009 3:40 PM (GMT -6)   
Hey Ed,

The acinar usually refers to a cluster type cells (groups of cancer cells). What I find interesting is that it is not usually assocaite in conjunction with prostate cancer, but it is associated with other gland type cancers.

Hope that helps.

David in SC
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA:
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 in place


Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 12/22/2009 3:49 PM (GMT -6)   
Thanks David. I tried looking it up on Google but all I could get was a bunch links to web sites with no clear explanation.
Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25380
   Posted 12/22/2009 3:52 PM (GMT -6)   
Ed, and please, with a capital P, don't think I am thinking this ,but the only time I heard the term used, was with a friend of mine that perished of Pancratic cancer, when one get's cancer there, it usually involves clusters of cancerous cells that eventually take over and shut down the pancereas. It might have been the wrong use of the word in the pathology report, if it were me, I would either ask my surgeon or call the pathology people directly and get a piece of mind feeling.

David in SC
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA:
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 in place


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 12/22/2009 8:06 PM (GMT -6)   
Here is some definition, basically pertains to the cells structure clustering or such:

ThesaurusLegend: Synonyms Related Words Antonyms
Adj. 1. acinar - pertaining to one of the small sacs (as in a compound gland)
acinic, acinose, acinous
2. acinar - pertaining to the individual parts making up an aggregate fruit like a blackberry

Based on WordNet 3.0, Farlex clipart collection. © 2003-2008 Princeton University, Farlex Inc.

Like a bunch of grapes off the vine together in a bundle all connected nearby to each other, is likely the cells description relating to 'acinar' , this is to make a visual conceptual thing you might compare it too, or like the way a blackberry, raspberry looks.
Youth is wasted on the Young-(W.C. Fields)

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