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New Member

Date Joined Dec 2009
Total Posts : 2
   Posted 12/31/2009 9:48 PM (GMT -6)   
Anyone have any experience with Trymix for ED after removal of prostate?

Veteran Member

Date Joined Apr 2008
Total Posts : 1382
   Posted 12/31/2009 9:55 PM (GMT -6)   
Welcome Kamanao
I am personally not familiar with trimix but I know several men that are and they will be chiming in shortly.

peace to you
My PSA at diagnosis was 16.3
age 47 (current)

My gleason score from prostate was 4+5=9 and from the lymph nodes (3 positive) was 4+4=8
I had 44 IMRT's
Currently on Lupron
I go to The Cancer Treatment Center of America
Married with two kids
latest PSA 5-27-08 0.11

PSA July 24th, 2008 is 0.04
PSA Dec 16th, 2008 is .016
PSA Mar 30th, 2009 is .02
PSA July 28th 2009 is .01
PSA OCt 15th 2009 is .11

Testosterone keeps rising, the current number is 156, up from 57 in May

T level dropped to 37 Mar 30th, 2009
cancer in 4 of 6 cores

Dink J.
New Member

Date Joined Dec 2009
Total Posts : 6
   Posted 12/31/2009 10:28 PM (GMT -6)   
Yeah, the TRIMIX shots hurt like hell. They don't do that for all depends on......whatever. They DO "work." But then I'd be in pain for two hours, and sore the next day. If that had been my last "shot" at FUNCTIONALITY, I'd have been grateful for the shots, I guess. I didn't mind the shots themselves, just the pain afterwards, which was quite impressive. Lucky for me, my physician at Hopkins who was handling the ED stuff was willing to do implant surgery, and I had it on Sept. 23, '09 (my original RPP was at Hopkins under a different surgeon, in April '08). The implant "works," there is no pain directly related to the equipment when it's....ahem, in action....but I've had constant pain in that region since Sept. 23 (it hurts to walk, it hurts to sit down, to get up, especially to lie down at night and get up in the morning). It has gotten a LITTLE better as time passes, and I'm optimistic. My G.P. says that the surgeon may have struck a nerve, and that this may be resolved with steroids. In which case, I plan to play major-league baseball, since everyone there seems to be on steroids, anyway. I'm 64, but the steroids work wonders (just ask Mark McGuire & Sammy Sosa, among others). Definitely TRY the TRIMIX. I was determined to get PART of my life back, that cancer had stolen (thymic cancer killed my wife Jeannie in 2005, so I'm p*ss*d at CANCER, period, and anything I can grab back from it, I plan to). To sum up, I am optimistic about the way the implant will turn out, in the long run, for me, and I do not at all regret trying the three "mixes" of shots and all the other apparatuses that I used earlier, nor do I regret the implant. It's bigger (the implant) than I thought, and it's like carrying a fishing tackle box around in my testicles. But the end result is.....better than what I had before. Good luck to you. Sally forth! And don't be too patient a patient. It was only 17 months after my RPP that I went for the implant, and I am glad I did that. (P.S., when my surgeon went in, for the RPP, he found a large blood clot beside the right side of my prostate gland--probably due to the biopsy performed by a urologist in my small hometown--and so they had to remove the nerve bundle on that side, just to dig out the blood clot. Dang, I hate when that happens.)
Oh, one last thing, of relevance to many who read these blogs: I couldn't get my earlier two physicians (both surgeons) at Hopkins to tell me a darned thing in the way of prognosis. My RPP surgeon just told me to go home "and enjoy every single day" (that should've come with a fortune cookie, but didn't), and after that guy left, another surgeon gave me very little help, and no encouragement (I have Gleason 7 [4+3], downgraded after surgery from the Gleason 9 I had on biopsy). So, I asked the surgeon whom I was considering for my implant, "Am I wasting my time and the insurance money to get an implant, if I'm just going to kick the bucket in a few years?"
He told me two things: (1) In a "worst-case scenario, I had 7 or 8 years left to live," so I could enjoy the implant in the meanwhile, and (2) even if I was taking hormone deprivation therapy, etc., later, I could still "pump it up" and enjoy. He didn't realize it, but he had given me the FIRST real "prognosis" I had heard from any doctor previously -- and I'm realistic, he cannot predict the natural history of my own particular prostate cancer -- but it was good that HE thinks that I have a "worst-case scenario" of 7 to 8 years. That's a hell of a lot more info than I had been given previously, by any doctor. So I immediately said, "I want the implant surgery," and so it was.....
By the way, if you haven't read my entry "Wanna hear some GOOD NEWS about PCa" that I entered on this site about five or six days back, go read it. It really DOES give most men with PCa hope for a longer life than they may been expecting.
Myself, I plan to take my new implant 'equipment' and go on tour with Tiger Woods next year. By then, I may be on steroids, so who knows how my golf game will go. And, besides, I'm not going to be touring with Tiger for the *golf,* anyway. Grin.

Veteran Member

Date Joined Jul 2006
Total Posts : 686
   Posted 1/1/2010 12:10 AM (GMT -6)   
Kamanao said...
Anyone have any experience with Trymix for ED after removal of prostate?
Pills did not work for me, so my doctor first prescribed Caverject injections (also known as edex).  It worked well, but is 100% alprostadil which caused much discomfort.  He suggested 'trimix' which had some alprostadil and two other parts 'papavarine' and 'phentolomine'.
I finally started using bimix which did not have the alprostadil. No more pain.  It takes a while to feel comfortable injecting yourself, but I have no problems now.  It works every time.
PSA up to 4.7 July 2006 , nodule noted during DRE
Biopsy 10/16/06 ,stageT2A
Very Aggressive Gleason 4+4=8  right side
DaVinci Surgery  January 2007
Post op confirms gleason 4+4=8 with no extension or invasion
no long term continence problems
Post surgery PSA continues to be "undetectable"
One side nerves spared
Bi-Mix for ED 
born in 1941

Veteran Member

Date Joined Apr 2008
Total Posts : 847
   Posted 1/1/2010 4:54 AM (GMT -6)   
Lots of guys here have good results with Trimix. I used Bimix with no pain, apart from a little discomfort at the actual time of the injection. After about 20 injections, I got the technique and dosage right and that gave 100% reliable erections.

You won't know how injections work out for you until you actually try. It's important not to give up at the first few failures -- you will probably have a few, but the successes more than make up for them.
Age 63 at diagnosis, now 64.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores.
Non-nerve sparing RRP on 7 March 2008.
Two nights in hospital; catheter out after 7 days.
Continent; no pads needed from the get-go.
Pathology showed organ confined and negative margins. Gleason downgraded to 4+4=8.
6-week : <0.05
7-month: <0.05
13-month: 0.07 (start of a trend?)
19-month: 0.09 (maybe)
After a learning curve, Bimix injections (0.2ml) worked well. From 14 months, occasional nocturnal erections. Have "graduated" to just the pump.

Steve n Dallas
Veteran Member

Date Joined Mar 2008
Total Posts : 4849
   Posted 1/1/2010 5:53 AM (GMT -6)   
Pills didn't work for me but Trimix does....Next to no pain for me...But I only need a very low dose.
Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.

Veteran Member

Date Joined Dec 2009
Total Posts : 1268
   Posted 1/1/2010 8:17 AM (GMT -6)   
Hey Kamanao,
I've been using Trimix for about seven months. 
My doctor originally started me on 0.1 ml.  That was way too much, the erection lasted 4 plus hours and it did hurt.  I'm curenntly using 0.035 ml., and feel no pain .... about a 2 hour erection (that takes some getting use to ... a pleasant problem).  0.035 ml isn't much fluid, and it is actually somewhat hard to measure; therefore, I prefer the  0.5 ml syringes ... I use 30 gauge (the fine needle seems less painful to inject) ... I've heard of others using a 31 gauge needle (its even finer).
I use a componding pharmacist that is located close to my home; 5 ml of trimix costs about $80 (at 0.035 ml per dose thats a lot of Trimix).  I've heard of other guys using mail order compunding pharamacies with good luck.
There is a lot of good information in the book, "Saving your SexLife" on injections in general and Trimix specifically.  I recommend you read this book carefully; especially the parts dealing with injections and possible side affects.
Good luck and Happy New Year,

Veteran Member

Date Joined Oct 2006
Total Posts : 626
   Posted 1/1/2010 1:00 PM (GMT -6)   

I have tried all of the interventions for ED from PCa and just two weeks ago had a penile implant installed.  First, let me say after two weeks I am pain free so I feel bad for Dink and his experience.  My first injection was Caverject(Alprostadil) in my surgeon's office and it did hurt and ache badly for three hours.  I told my surgeon's PA I could not use Alprostadil so he prescribed Bimix.  Bimix worked well for a while without any pain.  The problem I had with Bimix is to get the firmness of the erection I wanted I had too use a dose that resulted in my erection lasting 3 to 4 hours.  I had read on this forum where a couple of men had the same situation and had a custom blend of Trimix prescribed.  I did the same thing reducing the Alprostadil portion of the Trimix to one fourth of the normal formula.  That worked well with just a little aching.  I chose to go with an implant because the quality of my sex life was being impacted by the need to plan and dealing with the erection for 3 hours.  According to my urologist at a large university based clinic most men using injections will go in one of two directions.  They will move on to an implant or will eventually just stop having sex. 


Diagnosed 7/6/06, 1 of 10 core samples, 40%,Stage T1c, Gleason 3+3
Da Vinci on 11/01/06, Catheter out on 11/13/06
56 Years Old
Post Op Path, Gleason 3+3, Approx. 5% of prostate involved
Prostate Confined, margins clear
Undetectable PSA on 12/18/06, 6/25/07, 1/8/08
No more pads as of 1/13/07
Began injections in April '07

Regular Member

Date Joined Aug 2009
Total Posts : 152
   Posted 1/1/2010 2:37 PM (GMT -6)   
I'll be asking about it in two weeks, 11 months since RP. I do feel radiation tx in months 6-8 did set me back in that dept somewhat.

Veteran Member

Date Joined Dec 2008
Total Posts : 673
   Posted 1/1/2010 2:54 PM (GMT -6)   
Trimix is starting to work for me. Just need to get the dose and procedure worked out and I hope to be good to go soon. No pain yet. Injection really doesn't bother me, considering the alternative is nothing. I think a lot of guys here have had good success with injections. I'm still in the trial and error stage, so to say. Oral meds didn't do much except give me a headache.

-Nov/Dec 07, March 08 and Dec 08: Severe perineum pain . Septra/Bactrim for 8 months for diagnosed prostatitis.
-PSA start of 2008: 5.3..... PSA June of 2008: 7.3
-14 DRE all benign or nothing felt
-TRUS Biopsy Nov 08: 5 of 8 cores positive GS 3+3 or 6. 30-65%. Perineural invasion.
-General Health: pretty good, 5' 10", 180 lbs, slim.
-Open RP surgery: May 09 both nerve bundles spared. Bilateral lymph node dissection performed. Discharged 48 hours after surgery.
-Post Surgery Pathology: pT3a N0 MX, extraprostatic extension (EPE), stage III prostate cancer, lymph nodes clear, seminal vesicles clear, Gleason upraded to 3+4 GS 7. EPE within surgical margins. Other than prostate and EPE, all tissue removed negative for cancer involvement.
-Bladder control within 48 hours of catheter removal
-ED ongoing but improving significantly with Trimix at 7 months post-op. Oral ED meds didn't do much.

Veteran Member

Date Joined Jul 2009
Total Posts : 504
   Posted 1/2/2010 9:39 AM (GMT -6)   
Hi Kamanao,

I have been using Trimix since August and its 100% successful and I get absolutely no pain. My erections are 1 1/2 hours on average so the dosage is at the lower end and for me is spot on. I suspect those with pain are taking a bit more medication which results in pain and 3+ hour erections

ED oral meds did not work for me, the Trimix injections have been amazing. It does take a number of times of use to get the process perfected, now its so simple its silly, a much faster process administering than brushing ones teeth

My compound pharmacy charges $64 includes overnight delivery in box will reusable ice packs. Syringes are cheap 30 are $6 copay at any pharmacy, the auto injector is the way to go, Dr gave me that, makes the process foolproof and I never see the needle. For $70 I get approx 6 weeks of full 1.5 hour pain free erections 4-5 times a week, far cheaper than even generic Viagra

Any questions, just ask, many here are glad to help get you on the track to a wonderful love life, maybe better than even before PC removal !!
Age: 52
PSA (2008)=1.9
Biopsy on Jan 09, 2009
One (1) out of twelve (12) cores was positive, plus external nodule found
Gleason Score = 3+3
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, under .0

Ed C. (Old67)
Veteran Member

Date Joined Jan 2009
Total Posts : 2461
   Posted 1/2/2010 3:07 PM (GMT -6)   
Hi Kamanao,
I've been using trimix for over 6 months. My doctor wanted me to start with .1 dosage and see if that works which it didn't. He told me to increase it to .2 and that was also not enough. I now use .25 or .3 and that seems to give me a full erction that lasts 2 hours. You have to experiment and see what dosage works for you. I don't get any pain from the shot. I do use the VED before I give my self the shot and also after for just few minutes to make sure that the trimix stays in the penis. It works very time.
Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1

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