Bimix injections and alcohol ingestion

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clearwatercowboy
Regular Member


Date Joined Oct 2009
Total Posts : 135
   Posted 1/10/2010 7:29 PM (GMT -6)   
As some of you know, I was started on Bimix injections for ED in November 2009.  My mixture is a little different than some that I have seen, in that I inject phentalomine and Prostogladin-E, with a little Lidocaine for pain control.  On two seperate occasions this past couple of weeks, I have noticed than when I inject my usual workable dosage, following some alcohol (Bourbon) use, that it seems that the injection results are almost a complete failure.  The response is a non-functional, partial erection.  So, does someone out there have experience with this or am I just weird.  I do not recall that my Urology physician ever told me that alcohol would cancel the functionality of the Bimix.  I am aware that other medications commonly used for ED, i.e., Viagra, Levitra, Cialias, don't work well with alcohol. But, those medications work differently physiologically than the injections.
 
I am sure that my injection technique is "right on", and having worked in medicine and surgery for the past 35 years, one would think that I would have a good handle on injecting medications.
 
If anyone has similar experiences with this expensive, and frustrating occurances, I would love to hear your take on it.
 
Thanks
Dallasconfused
RRP May 04, 2009
Pre-op Gleason 6
Post-op Gleason 7


T40
Regular Member


Date Joined Oct 2009
Total Posts : 103
   Posted 1/10/2010 9:43 PM (GMT -6)   
Alcohol will pretty much negate the effects of ED drugs. Period.
Age 40
Pre-op PSA was 5.8 from wellness test on May 19, 09
Follow up test from uro was 4.6 with a 9.3% free psa
Gleason 3+3 in one core, 3+4 in second core of 12 samples taken
Surgery performed August 19th, 09.
One side nerves spared. Nerve graft on other side.
Six weeks incontinence almost over. ED a work in progress but seeing some response.
4 months no longer using pads. ED using trimix with positive response.
Post op October 2nd, 2009 All margins were negative. PSA results in a few days.
Post op pathology 3+4 PT2A NOMO
6 wk PSA .004
4 month PSA .003 12-18-09


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 1/10/2010 10:57 PM (GMT -6)   
I would say, yes the alcohol is wiping out the Bimix. If Sudafeds wipe it out then it stands to reason that something in your bloodstream could also cause it to not work
Stats:
Age: 52
PSA (2008)=1.9
Biopsy on Jan 09, 2009
One (1) out of twelve (12) cores was positive, plus external nodule found
Gleason Score = 3+3
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, under .0


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4829
   Posted 1/11/2010 6:20 AM (GMT -6)   
I think you've seen first hand what happens....
Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 1/11/2010 7:16 AM (GMT -6)   
I use the same bimix combo that you use but have not had that problem. I have an appt. with my uro today and will ask him ( if I can remember).

Carlos
Diagnosed 2/2008 at age 71, PSA 9.1, Gleason 8 (5+3)and stage T1c.  CT and bone scan neg.
Robotic surgery 5/2008, nerves spared, bladder neck spared with pelvic floor reconstruction.
All margins, SV and lymph nodes were neg.  Staged pT2c, Gleason sum 8 (5+3).
Continent at 6 weeks. 
PSA <0.1 at 20 months, Jan. 4. 2010.


Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 1/11/2010 10:35 AM (GMT -6)   
clearwater,  I asked my uro about mixing alcohol with bimix.  He doesn't believe it would have much effect unless someone were to have so much that they were unable to inject properly.  I also got a new prescription to try trimix on the basis it might be more economical.  My local pharmacy charges the same for either prescription.  I believe some posters use half as much trimix and still get good results. 
 
Carlos
Diagnosed 2/2008 at age 71, PSA 9.1, Gleason 8 (5+3)and stage T1c.  CT and bone scan neg.
Robotic surgery 5/2008, nerves spared, bladder neck spared with pelvic floor reconstruction.
All margins, SV and lymph nodes were neg.  Staged pT2c, Gleason sum 8 (5+3).
Continent at 6 weeks. 
PSA <0.1 at 20 months, Jan. 4. 2010.


clearwatercowboy
Regular Member


Date Joined Oct 2009
Total Posts : 135
   Posted 1/11/2010 8:36 PM (GMT -6)   
Thanks guys for the input.
 
I spoke with the Compound Pharmacist today about this problem.  He suspects that the alcohol could be interferring with the Bimix, and suggests that I experiment with it and see if I can define what is going on.  He also suggests that if I wanted to have a drink of alcohol, I could, and then just increase the doseage of the Bimix to compensate.  That makes me a little nervous, in that, if I injected too much I would be making a trip to the local Emerg. Department to get treated for the dredded "permanant erection".
 
So, guess the best way to deal with it, is to avoid the alcohol completely, and focus on what we are trying to accomplish in the first place.
 
Carlos, ..... if you remembered to ask your Urologist about this subject, let me know what they had to say on the matter.
 
Thanks
Dallas
RRP May 04, 2009
Pre-op Gleason 6
Post-op Gleason 7


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 1/11/2010 8:59 PM (GMT -6)   
It takes approx 1 hr for the body to eliminate alcohol from 1 drink, beer or glass of wine. Maybe just waiting may be all that is needed

Certainly not worth a trip to the ER for having a beer !!
Stats:
Age: 52
PSA (2008)=1.9
Biopsy on Jan 09, 2009
One (1) out of twelve (12) cores was positive, plus external nodule found
Gleason Score = 3+3
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, under .0


Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 1/11/2010 10:08 PM (GMT -6)   
If alcohol reduces the blood supply to the important area, that would account for the symptoms. Injections depend on there being a good blood flow to the area, so anything reducing that could cause a flop.

en.wikipedia.org/wiki/Alcohol_and_sex says that alcohol causes the body to slow down, so maybe that includes blood supply.
Pre-op:
Age 63 at diagnosis, now 64.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores.
Operation:
Non-nerve sparing RRP on 7 March 2008.
Two nights in hospital; catheter out after 7 days.
Post-op:
Continent; no pads needed from the get-go.
Pathology showed organ confined and negative margins. Gleason downgraded to 4+4=8.
PSAs:
6-week : <0.05
7-month: <0.05
13-month: 0.07 (start of a trend?)
19-month: 0.09 (maybe)
ED:
After a learning curve, Bimix injections (0.2ml) worked well. From 14 months, occasional nocturnal erections. Have "graduated" to just the pump.


clearwatercowboy
Regular Member


Date Joined Oct 2009
Total Posts : 135
   Posted 1/11/2010 11:47 PM (GMT -6)   
Piano,

Thanks for the information and link. As someone earlier posted, I guess I have my answer....... No more room for alcohol when in the mood to play !!

Dallas
RRP May 04, 2009
Pre-op Gleason 6
Post-op Gleason 7

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