has anyone heard about T cells

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deer hunter
Regular Member


Date Joined Jan 2010
Total Posts : 246
   Posted 2/10/2010 7:48 PM (GMT -6)   
has  anyone heard about taking a  person T cells out  and  cranking them and putting them back in to destory cancer cells in other words beefing up your immune system. bucky ga.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 2/11/2010 6:22 AM (GMT -6)   
Yes, Dr. Scholz and probably Bahn and some others are envolved in such works, is what I believe I have heard. New way to try and combat PCa on a cellular level and not a drug therapy. You might try reading or searching about Dendritic cells and how that works, kind of like pac-man like in how it does its thing.  Google stuff here is one:
 

Titre du document / Document title

Dendritic cells and the control of immunity : Enhancing the efficiency of antigen presentation

Auteur(s) / Author(s)

STEINMAN Ralph M. (1) ;

Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)

(1) Laboratory of Cellular Physiol ogy and Immunology, Rockefeller University, New York, NY, ETATS-UNIS

Résumé / Abstract

Background: Relevant antigens often are known for diseases that involve the immune system. Yet purified antigens by themselves do not control immunity, especially T-cell immunity. For example, many antigens have been defined for HIV-1 and melanoma, but good HIV-1 vaccines and melanoma immune therapies are lacking. Dendritic cells (DCs) are important intermediaries between antigens and better control of the immune system. Methods: Some properties that allow DCs to control immunity are reviewed, followed by new studies using DCs as adjuvants in humans. An emerging area is then detailed, the special mechanisms whereby DCs enhance the formation of ligands for T-cells, i.e., complexes of major histocompatibility complex (MHC) products and antigenic peptides. Results: Once criteria were developed to identify and isolate DCs, several functional properties became evident. DCs are unusually potent in initiating T-cell mediated immunity in culture. In vivo, DCs are positioned to capture antigens and migrate to T-cell areas of lymphoid organs. There, DCs are able to prime animals, controlling the MHC restriction of the primed T-cells and inducing resistance to pathogens. DCs pulsed ex vivo with antigens are now being used to induce and expand T-cell immunity in humans. To optimize their use, two areas of DC function need to be harnessed: their terminal differentiation or maturation, and antigen uptake. DCs capture most types of antigens at an immature stage of development, but the cells must receive additional stimuli prior to acquiring potent T-cell stimulatory activity. Stimuli from microbes, inflammation and trauma mature DCs. These change the DCs in several ways, even inducing the formation of MHC II-peptide complexes or T-cell receptor (TCR) ligands. The latter move to the surface in nonlysosomal vesicles that simultaneously carry CD86 costimulatory molecules for T-cell activation. Both MHC and CD86 remain co-clustered in patches at the DC surface. DCs also express a receptor, DEC-205, that enhances antigen uptake and presentation. DEC-205 recycles in an unusual manner through MHC class II-rich, late endosomes or lysosomes, dramatically increasing the presentation of bound ligands. Additionally and importantly, DCs can process dying cells and immune complexes onto MHC class I products, events that are termed the exogenous pathway or cross presentation. Conclusions: The control of the immune system by DCs reflects numerous specializations, not a single magic bullet. These specializations include a number of mechanisms that increase the efficiency of antigen uptake and MHC-peptide complex formation. The harnessing of these and other features of DCs provides opportunities for improving immune-based therapies and vaccine design.

Revue / Journal Title

The Mount Sinai journal of medicine   ISSN 0027-2507   CODEN MSJMAZ 

Source / Source

2001, vol. 68, no3, pp. 160-166 (45 ref.)

Langue / Language

Anglais

Editeur / Publisher

Mount Sinai Medical Center, New York, NY, ETATS-UNIS  (1970) (Revue)
==============================================================
Some info on the theory and practice as written above, you can google Dendritic and find source info. Leaves you scratching your head as to what does that all mean, so search for other sources and read-read.
 
Zufus 


Youth is wasted on the Young-(W.C. Fields)

Post Edited (zufus) : 2/11/2010 5:30:35 AM (GMT-7)

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