what exactly is a negative or failed DRE?

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Regular Member

Date Joined Feb 2010
Total Posts : 183
   Posted 2/14/2010 10:48 AM (GMT -6)   
I am guessing cysts that are cramming and held together by the prostate membrane?

OR could be calcium deposits?
Or a swelling from irritated cells, infection?

I find it interesting with that negative spot on the prostate that the Urologist still wants to do a saturation biopsy? indicating to me not all those hard spots hide a cancer?

Is it these malfunctions that cause ED? I have had ED for 20 years? I am 67 now.
It still works but ever so briefly.

My Urine tests are always negative.
I've had a periodic sore groin for a year now.
My PSA was a steady 2.5 10 years ago climbing and taking a jump to 3.75 then 3 months later 4.65.
Now it seems to be stable at 4.5

Color doppler tomorrow, then Prepare for a Biopsy.
I am leaning toward the IV Sedation. I can handle puking. I've done that many times.
I don't know how many have nasea?

PSA NOW 4.5, failed DRE
I Didn't believe it and still don't but I saw 7 Urologists!!! Is that a record.
All said Failed DRE!!!!

Steve n Dallas
Veteran Member

Date Joined Mar 2008
Total Posts : 4849
   Posted 2/14/2010 11:31 AM (GMT -6)   
I was told the nodules they found could very well be calcium build up. But the only way to tell is from a biopsy.
Almost wish the doc hadn't mentioned calcium cause it was depressing when the hope was goneshakehead
On the other hand - I had a low PSA the whole time and no telling what would have happend if I didn't have nodules.
Then there's the part where my GP couldn't feel the nodules due to him being Asian and having rather small hands. Had I seen him first and him not finding the nodules...Again - no telling what might have happened.

Age 54   - 5'11"   205lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.

Post Edited (Steve n Dallas) : 2/14/2010 9:35:19 AM (GMT-7)

John T
Veteran Member

Date Joined Nov 2008
Total Posts : 4269
   Posted 2/14/2010 1:22 PM (GMT -6)   
Why are they doing a color doppler then a biopsy? The whole reason for a color doppler is to better target a biopsy to suspicious areas. They are usually done together. The only time a biopsy with a color doppler is not done is if there is nothing suspicious to target.

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.


Regular Member

Date Joined Feb 2010
Total Posts : 183
   Posted 2/14/2010 5:13 PM (GMT -6)   
wow John, way to go!!!! I'm just starting this trip and I get happy when I see a good experience like yours
I opted for the Sonagram, since Urology is more keen on straight to a biopsy after a firm DRE.
I'm a little hesitant.
Lately statistical new has not been positive about prostrate treatments and outcomes.

psa 4.5 and steady for 1 year
no symptoms
age 67

Veteran Member

Date Joined May 2009
Total Posts : 2692
   Posted 2/14/2010 5:23 PM (GMT -6)   
Obviously a DRE is a very subjective thing. Subjective to the guy who has his finger in your butt. We just have to trust his tactile expertise , and the fact that his finger has been in a lot of butts before ( I know, not a pretty thought ), and that he knows a good feel from a bad feel.

Good luck, and keep on questioning.
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared, but carved up a little.
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks .
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)
5 month PSA <.03 (undetectable)
6 Month PSA <.01
1 pad a day, no progress on ED.  Trimix injection
No pads, 1/1/10,  9 month PSA < .01

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