First Trimex Injection.

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Regular Member

Date Joined Dec 2009
Total Posts : 97
   Posted 2/22/2010 11:21 PM (GMT -6)   
The PA gave me the first trimex injection. Injected .20 ml. Gave me less than 50% erection, but he was pleased with the response. Just very mild discomfort. Next week in his office, he will have me inject .30 ml. Will have a little trepidation about doing it myself, but it sounds like after a few times it becomes a walk in the park.

Age 70

PSA 5/2008- 3.6, PSA 7/2009- 6.1, retested 9/2009-5.1.
Biopsy 9/2009. 4 of 12 positive. Gleason 3+4=7
CT and bone scan negative.
Robotic De Vince Surgery 10/29/2009. 1 night in hospital. No pain. Cath out on 11/6
Pathology Report: Gleason score 3+4. Margins slightly involved <.1mm to .25mm. Perineural invasion present, stage pT2c. Tumor 18%. Seminal Vesicle - absent, Lymph Nodes 0 of 6.
Continence- first 4 weeks after cath out Dry at night, rest of time, bladder held nothing. 6-7 pads per day. as of 12/30 no pads most of time. almost dry except for a few drips. I keep doing Kegels.
ED. Started VED on 12/17/2009. Every other day for 15 min. Cialis .20 mm twice a week
PSA 02/08/2010 <.1
02/22/10 Trimex injection .2ml less than 50% just a little discomfort.

Veteran Member

Date Joined Aug 2009
Total Posts : 670
   Posted 2/22/2010 11:59 PM (GMT -6)   
Yes, it can be intimidating at first. I still have a bit of a feeling of "am I really going to stick myself?" but it always is very easy and almost painless. Compared to your surgery, it's nothing. If the trimix ends up giving you discomfort, there is also bimix, which eliminates the ingredient (alprostadil) that sometimes causes the discomfort for some. There is also an auto-injector if you don't want to watch - about $70, your doc can prescribe it. I preferred being able to see what I was doing.
Gleason, 3+4; PSA, 7
Robotic Prostatectomy, March 2008 (Age 48 then), nerves both sides spared, post surgery analysis confirmed 3+4 Gleason,
cancer contained, no penetration, lymph nodes clear
PSA consistently <0.1 since surgery until Oct 09, 0.1; retested Oct 09, <0.1, Jan 10, 0.2; retest confirmed 0.2

Veteran Member

Date Joined Jul 2009
Total Posts : 504
   Posted 2/23/2010 3:10 AM (GMT -6)   
Hi Ricky,

Yes it can be an ominous experience at first, but you will get the process down pretty soon. a jump of .10 is a huge jump, you may only need a few more units to get you to 100% or just a post injection hold of the medicine in the penis

I found that the injection was most effective if I held the base of the penis tight with my left hand while injecting ( with auto injector) with my right. Then after the injection, press and massage the area with the wipe for approx 60 seconds, it helps distribute the medication before the blood flow flushes it out

Try to get 30 or 31 gauge needles they are a bit smaller than 28's and much thinner than 26's

Here is a BD auto injector that I have been using for months and it works perfect, just aim and click
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function

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