Trimix - It worked!

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Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3732
   Posted 2/26/2010 2:53 PM (GMT -6)   
Today was the third time trying Trimix and it was (almost) the charm. I tried .08 at the Uro, a couple of days later I tried .12 and got a good partial. Today I tried .16 and got a 90%er that was even usable. It lasted about 30 minutes - which is 25 minutes longer than I lasted before the surgery. tongue

Better living through chemistry!

After 7 months, I now feel there is hope.
Now if only I can get rid of these @#$% pee pads.

Jeff
Married 34 years, DX Age 56. First routine PSA test on April 8, 09: 17.8. Start 2 weeks of Cipro to rule out protatitis. May '09 PSA: 22.6, 3 weeks later: PSA: 23.2.
Biopsy 6/10/09: 7/12 scores positive, 20%-70%, Gleason 6=3+3. Bone and C/T scans neg.
RP DaVinci -7/21/2009 @ Univ of Roch Medical Center
Left nerve gone, right partial spared.
Catheter removed - 7/31/2009 Pathology report received:
Gleason 3+4=7, Tumor size: 2.5 x 1.8 cm, location: both lobes and apex.
Extraprostatic extension present; Perineural invasion: present, extensive.
No Malignancy in Seminal Vesicle, vasa deferentia, lymph nodes 0/13
Prostate mass 56 grams. Pathologic Stage: pT3aN0MX
Post Surgery Status:
Potency - 12/11 5 months, Still no activity, zip. Using pump daily since 11/11. No effect with 20 mg of Cialis or 100 mg of Viagra. Shots, See Uro 1/22/10 Trimix unsuccessful.
Incontinence - 8/20 4 full pads per day
.. 9/7 3-4 full pads per day (Try cutting down on fluids. Bad idea. I know.)
11/14 4 months: Still 3 pads per day. 420ml/day, 91 um leak.
12/11 5 months: Still 3 pads per day. 400-450ml/day
1/11/10 6 months: Still 3 pads but leak is now 320 ml (5 day avg.)
Post Surgery PSA - 9/3 6 weeks - 0.05; 10/13 3 months - 0.04, 1/14 6 months - 0.05.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 2/26/2010 2:55 PM (GMT -6)   
As Jed used to say: Whee Doggie, Granny, that sure is a good one! Report, that is. Now fine tune that sucker...lol smilewinkgrin

cocrgolfer
Regular Member


Date Joined Oct 2009
Total Posts : 171
   Posted 2/26/2010 3:20 PM (GMT -6)   
Hey Jeff,


Great. Let's change your moniker.....Woodiedguy!



Steve

Ricky2
Regular Member


Date Joined Dec 2009
Total Posts : 97
   Posted 2/26/2010 4:41 PM (GMT -6)   
Jeff,

Question on quantity of trimex. I just had my first injection in the Uro's office on last Monday. He said he injected .20 ml...at least i I think it was mill liter. I got some result, but less than 50%. Next Monday he is going to have me injected .30 ml. Is your injection ml? If so you certainly don't need much of the stuff to get good results.

Ricky
Age 70

PSA 5/2008- 3.6, PSA 7/2009- 6.1, retested 9/2009-5.1.
Biopsy 9/2009. 4 of 12 positive. Gleason 3+4=7
CT and bone scan negative.
Robotic De Vince Surgery 10/29/2009. 1 night in hospital. No pain. Cath out on 11/6
Pathology Report: Gleason score 3+4. Margins slightly involved <.1mm to .25mm. Perineural invasion present, stage pT2c. Tumor 18%. Seminal Vesicle - absent, Lymph Nodes 0 of 6.
Continence- first 4 weeks after cath out Dry at night, rest of time, bladder held nothing. 6-7 pads per day. as of 12/30 no pads most of time. almost dry except for a few drips. I keep doing Kegels.
ED. Started VED on 12/17/2009. Every other day for 15 min. Cialis .20 mm twice a week
PSA 02/08/2010 <.1
02/22/10 Trimex injection .2ml less than 50% just a little discomfort.


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3732
   Posted 2/26/2010 4:52 PM (GMT -6)   
Ricky,

The syringes I use are 1cc or 1 ml. The .16 was only about 1/2 inch on the scale. Not much at all! My mix was called Trimix #1. Not sure if that makes a difference.

Steve,
I like it: "Woodied Guy". I'll consider that when I reach a full 100%.

By the way, my leak seems unaffected by the activity. Rats! I hoped I could consider that therapy.

Jeff

Post Edited (Worried Guy) : 2/26/2010 5:04:51 PM (GMT-7)


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4088
   Posted 2/26/2010 5:01 PM (GMT -6)   
Yahoo!!!!!! Party Time!!!!!! I do know that feeling of having success after waiting so long. Jeff I am so pleased that the Tri-Mix worked. Talk to you soon.

Jeff T
Cajun Country
Jeff T Age 57

9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable

10th month PSA <0.01
1year psa <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next. Next step injections.
15 months out injections Caveject (success)


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3732
   Posted 2/26/2010 6:09 PM (GMT -6)   
The Uro said to not use it more often that once in 48 hours. I'll have to wait until Sunday before I can try .20. This is very exciting!
I will try to get one of Mr Gimpy's suggested auto-injectors. The injection part still gives me the creeps. I'll never make a good IV drug abuser.

tatt2man
Veteran Member


Date Joined Jan 2010
Total Posts : 2840
   Posted 2/26/2010 7:38 PM (GMT -6)   
Jeff:
Congrats on the woody - maybe this will help get your mind off PCa for a while - I am sure you wife will appreciate the increase in the time-line - a good diversion for her too.
This will certainly help lift your spirits and self-worth - very pleased for you.
Hopefully your doctor talked to you about rotating injections sites ( left and right side - dominent and other hand being used to inject)

Keep up with the kegels re: pads -

I will be investigating trimix / bimix when I see my doctor in April. My Mr. Happy gets thicker but not much else...

Once again - congrats !!!

BRONSON
.................
Age: 54 - gay - with spouse, Steve - 59
PSA: 04/2007- 1.68 - 08/2009 - 3.46 - 10/2009 - 3.86
Confirmation of Prostate Cancer: October 16, 2009 - 6 of 12 cancerous samples , Gleason 7 (4+3)
Doctor: Dr. Mohamed Elharram -Urologist / Surgeon - Peterborough Regional Health Centre
Radical Prostatectomy Operation: November 18, 2009 , home - November 21, 2009
Post Surgery Biopsy: pT3a- gleason 7 - extraprostatic extension - perineural invasion - prostate weight - 34.1gm -
ED Prescription: Jan 8/2010 - started daily 5mg cialis
location: Peteborough, Ontario, Canada
............


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25364
   Posted 2/26/2010 7:39 PM (GMT -6)   
Way to go, Jeff!!!!!! May the wood stay with you.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12 in at the same time, 2/8-Cath #11 out - 21 days


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3732
   Posted 2/26/2010 7:52 PM (GMT -6)   
Bronson, I am being very careful about alternating sides. I write it down. Would you expect anything less from a mental case like me?

David, Jeff, And May the Wood be with you too. Actually I found it started up again after I got dressed and was sitting on my tractor snowblowing my driveway. We had 15 inches with drifts of 3 feet - taller than the drift cutters on the blower. "Someone" should have been outside doing the driveway earlier when the snow was only 8-10 inches deep -but he was busy. Anyway, about 10 minutes into the job I started feeling pressure inside my snowsuit. I was getting a Trimix woodie again! Useless. I like my Cub Cadet but getting hard over it is just too much.

I will sleep well tonight.
Jeff Too

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4088
   Posted 2/26/2010 7:57 PM (GMT -6)   
That gives new meaning to "A man and his tools" :)
Jeff T Age 57

9/08 PSA 5.4, referred to Urologist
9/08 Biopsy: GS 3/4=7
10/08 Nerve sparing open RRP- Path Report: GS 3+3=7 Stg. pT2c, margins clear
3 mts: PSA .05 undetectable

10th month PSA <0.01
1year psa <0.01
ED- 5 mg Cialis daily, pump daily, going to try MUSE next. Next step injections.
15 months out injections Caveject (success)


Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2457
   Posted 2/26/2010 8:38 PM (GMT -6)   
Congratulations Jeff, You have now joined the chemical club. Next time try ,20 and you will last 2 hours.
Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm in circumference.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1
11.5 months test 1/21/10 result 0.004


LenB
Regular Member


Date Joined Jul 2009
Total Posts : 102
   Posted 2/27/2010 9:30 AM (GMT -6)   
Greta news Jeff. Now, don't try to wear it out!!!!  tongue
Age: 65
DX: 7/10/09
Gleason: 7
Biopsey: 2 chips with some cancer cells out of 30.
Robotic Surgery: 9/10/09
Cath out: 9/23/09
1st post op PSA: 10/20/09 <0.1
2nd post op PSA:  1/25/10 <0.1
 


Colin45
Regular Member


Date Joined Feb 2009
Total Posts : 216
   Posted 2/27/2010 9:10 PM (GMT -6)   
Hi Jeff good to hear something is going your way at long last maybe the pee pad problem may get better next
 
 
Age 64 From UK now in Thailand Baby boy born 2/14/2009
First PSA was showing 9.73 on 1/21/09.   on 5/7/09 PSA 9.78  Free PSA 0.83   Free:Total  PSA 0.08 
1/28/09 Biopsy carried out 12 core results show no adenocarcinoma
5/15/09 24 Core biopsy results Gleason'S Grade 3+2=5
Involving approx 30% of one out of 12 cores on each side no perineural or angiolymphatic invation identified
One side PIN High Grade Bone scan clear 
Open surgery 7/27/09
Prostate Gland weighting 34 grms lost one nerve bundle
Gleason upgraded to 3+3 Tumour not close to prostatic capsule Seminal Vesicles not involved by Tumour 6 Lymph Nodes negative for Malignant cells
First PSA Nov 2009 was 0.06 Continence 99% occasional stress dribbles no ED from first day after catheter removed


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 2/28/2010 12:14 PM (GMT -6)   
Hi Jeff,

Welcome to the Trimix side,. You likely now have the right dosage but need to perfect the process to get longer lasting erections. The more time you keep the meds from initially flowing out of the penis the longer your erection will last
Stats:
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3732
   Posted 2/28/2010 1:12 PM (GMT -6)   
Mr Gimpy,
I am now looking for the auto-injector you recommended. (BD) My pharmacy does not carry them and recommended another pharmacy that is closed today. Ill talk with them on Monday. I can really see how that would make things more psychologically manageable. In my wildest dreams I never thought I'd ever be sticking a needle there.

Colin, Yes this was a big step. I think I see some light far, far, at the other end of the tunnel.

Len and Ed, Next time I will use 0.20. If it really lasts 2 hours I will be sure to stick it in the 2 feet of snow we have here.

Jeff T, A man and his tools. I already have a tool box in the garage, basement, barn, now I've added one to the bedroom - in addition to the one I carry with me.
Married 34 years, DX Age 56. First routine PSA test on April 8, 09: 17.8. Start 2 weeks of Cipro to rule out protatitis. May '09 PSA: 22.6, 3 weeks later: PSA: 23.2.
Biopsy 6/10/09: 7/12 scores positive, 20%-70%, Gleason 6=3+3. Bone and C/T scans neg.
RP DaVinci -7/21/2009 @ Univ of Roch Medical Center
Left nerve gone, right partial spared.
Catheter removed - 7/31/2009 Pathology report received:
Gleason 3+4=7, Tumor size: 2.5 x 1.8 cm, location: both lobes and apex.
Extraprostatic extension present; Perineural invasion: present, extensive.
No Malignancy in Seminal Vesicle, vasa deferentia, lymph nodes 0/13
Prostate mass 56 grams. Pathologic Stage: pT3aN0MX
Post Surgery Status:
Potency - 12/11 5 months, Still no activity, zip. Using pump daily since 11/11. No effect with 20 mg of Cialis or 100 mg of Viagra. Shots next See Uro 1/22/10 Trimix #1. Try 0.08- 25%, 0.12-25%, 2/26/10 try 0.16 First Success! 90%.
Incontinence - 8/20 4 full pads per day
.. 9/7 3-4 full pads per day (Try cutting down on fluids. Bad idea. I know.)
12/11 5 months: Still 3 pads per day. 400-450ml/day
2/26/10 7 months: Still 3 pads but leak is now 320 ml (5 day avg.)
Post Surgery PSA - 9/3 6 weeks - 0.05; 10/13 3 months - 0.04, 1/14 6 months - 0.05.

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