How much trimex will it take?

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Ricky2
Regular Member


Date Joined Dec 2009
Total Posts : 97
   Posted 3/1/2010 12:11 PM (GMT -6)   
Went to the Uro office and injected .30ml up from .20ml last week. I got only about 50% erection, not very usuable. He said i am now on my own and to try .40ml next time. That seem like a lot of trimex. I asked him what the mixture of the trimex and he said it was the "standard mix". He said keep going up .10 until I get a usuable erection. He said that they rarely have a failure with this medicine. How high of a dose have people used?

Ricky
Age 70

PSA 5/2008- 3.6, PSA 7/2009- 6.1, retested 9/2009-5.1.
Biopsy 9/2009. 4 of 12 positive. Gleason 3+4=7
CT and bone scan negative.
Robotic De Vince Surgery 10/29/2009. 1 night in hospital. No pain. Cath out on 11/6
Pathology Report: Gleason score 3+4. Margins slightly involved <.1mm to .25mm. Perineural invasion present, stage pT2c. Tumor 18%. Seminal Vesicle - absent, Lymph Nodes 0 of 6.
Continence- first 4 weeks after cath out Dry at night, rest of time, bladder held nothing. 6-7 pads per day. as of 12/30 no pads most of time. almost dry except for a few drips. I keep doing Kegels.
ED. Started VED on 12/17/2009. Every other day for 15 min. Cialis .20 mm twice a week
PSA 02/08/2010 <.1
02/22/10 Trimex injection .2ml less than 50% just a little discomfort.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 3/1/2010 12:25 PM (GMT -6)   
Ricky, like most everything else here, it's variable. Each one reacts differently. That said, .30ml should stiffen a rope and definetly work on you. Are you familiar with the pre-plump and ring technique to expand the penile cavities and to retain the blood and the drug inside, allowing time for it to be adsorbed before leaking out of the penis due to veinous leakage? If you aren't familiar with the techniuqe, lets us know and we can help there. The big advantage is you can get some blood into the cavities, then inject the drug, for a better mix, and how the blood/drug mix and allow the tissue to have as much chance as possible to soak up the drug. That's what works best for the more problematic guys here having trouble.
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
32 mts: PSA's: .04 each test since surgery, ED Continues-Bimix .3ml PRN or Trimix .15ml PRN


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 3/1/2010 12:40 PM (GMT -6)   
Hi Ricky,

The success of Trimix is far more than just the dosage. I have to say that Trimix and perhaps Bimix as well is far from an inject and hope process. For me I am having 100% success for months but in most part because of the process I use.

One you have completed the pre-shot, wash hands and alcohol prep of the site

1) Try as best you can to get as much of an erection as possible before you inject, even "only" 20-30% helps in the success of the Trimix shot greatly. This also helps to identify where the small veins are, miss them and you likely do not get a drip of blood

2) I use an auto-injector which means I can inject and release meds with only my right hand

3) My left hand has formed a ring around the base and is preventing blood loss, which also means the Trix is staying in the penis being absorbed

4) Once I release the auto-injector ( with right hand) , I slowly push the plunger in to inject the medication

5) I remove the auto injector and with my right hand I put the alcohol swab on the insertion site and press with my thumb and massage around the entire area with my thumb and index finder for approx 60 seconds. My left hand is still holding the base

For me at this point I can begin to see an increase in size but its not all the way there yet

6) I then with my left hand release and "milk" the base like I am forcing more blood from the base towards the head of the penis. I do this perhaps 8-10 times. Each pump I can see a noticeable increase in size

All told I think it takes me 3 minutes to reach complete hardness and it stays that way for approx 1.5 hours, no pain at all, or aches, but that seems to vary by patient

I alternate the right and left side for shots and use a spot close to the head

Going from .30 to .40 is a big jump, perhaps you should try perfecting the process 1st , then go up in increments of 10% at a time, so from .30 go to .33

I suspect you that once you get the process down you will use less than .30. For me I was using .25 with hit and miss success early on. I have been using .20 for the past 3-4 months and that works every time for me

As a precaution, pick up some Sudafed, NOT THE PE version. Get the one with Pseudoephedrine, It will be behind the pharmacy counter of any drugstore, it is NOT out on the shelves. No RX needed. I have never needed to use it but its best to keep it handy just in case
Stats:
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function


Ricky2
Regular Member


Date Joined Dec 2009
Total Posts : 97
   Posted 3/1/2010 3:56 PM (GMT -6)   
Jim and Gimpy. Thanks for your very helpful response. I do not know exactly how the pre-plump and ring method works. I do have a Osbon Eractaid pump and Osbon rings. I have been using the pump largely for therapy. I assume that i pump up the penis and keep the blood in with the ring and then inject the Trimex. When i get the prescription from the pharmacy. (my uro sent the prescription to some pharmacy in FL) I will try that. How long should I leave it before I take off the ring? Do you think I should back off the amount when I try this? You guys have been great!

Ricky
Age 70

PSA 5/2008- 3.6, PSA 7/2009- 6.1, retested 9/2009-5.1.
Biopsy 9/2009. 4 of 12 positive. Gleason 3+4=7
CT and bone scan negative.
Robotic De Vince Surgery 10/29/2009. 1 night in hospital. No pain. Cath out on 11/6
Pathology Report: Gleason score 3+4. Margins slightly involved <.1mm to .25mm. Perineural invasion present, stage pT2c. Tumor 18%. Seminal Vesicle - absent, Lymph Nodes 0 of 6.
Continence- first 4 weeks after cath out Dry at night, rest of time, bladder held nothing. 6-7 pads per day. as of 12/30 no pads most of time. almost dry except for a few drips. I keep doing Kegels.
ED. Started VED on 12/17/2009. Every other day for 15 min. Cialis .20 mm twice a week
PSA 02/08/2010 <.1
02/22/10 Trimex injection .2ml less than 50% just a little discomfort.


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 3/1/2010 5:11 PM (GMT -6)   
Hi Ricky,

The ring should in theory be awesome at keeping blood flow in the penis while the Trimix is being worked in. You should still massage in the Trimix at the area of injection so that it distributes to both chambers.

Your could easily experiment with a .25 dosage this way, if that does not work, then move back to .30, remember to much medication is way worse than to little.

I think you can leave the ring on for 3 or 4 minutes without causing any problems, some people keep the ring on and have intercourse, which is way longer than you need it for
Stats:
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 3/1/2010 5:22 PM (GMT -6)   
Ricky, using your pump, pump up about 25%, just enough to get some blood in the penis and to 'plump' it up. At that point, you can roll off the ring to hold the blood in. Then do the injection, it makes it much easier to know when you are in the cavity, you can feel the needle 'drop' into it, by feeling less resistance. Inject as usual, and very gently massage the penis to spread the drug throughout and allow for maximum adsorption. Leave the ring on for 3 to 5 minutes (normally a ring can be left on at full erection for not more than 30 minutes, by the way) to keep the blood in and the drug adsorbing. Upon removal of the ring, continue very gentle massage. Continued stimulation of your favorite type will keep the erection growing and help maintain it for the full length of the drugs effective time. The injections are virtually painless, especially if you have used the plump and ring method, which I find to be painless. I was pleasantly surprised to discover that they were painless when you are 1/4 erect. Erections lasting longer than 4 hours will probably need some medical care. My doc said if mine was still at least 1/2 erect then, to seek treatment. Sudafed, the original real stuff, should be kept in case you need it, and you can take it at around the 3 hour mark if you have any worries about priapism.
James C. Age 62
Co-Moderator- Prostate Cancer Forum
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
32 mts: PSA's: .04 each test since surgery, ED Continues-Bimix .3ml PRN or Trimix .15ml PRN


Romeo
Regular Member


Date Joined Aug 2009
Total Posts : 23
   Posted 3/1/2010 7:06 PM (GMT -6)   

Ricky,

 

I strongly suggest you start out with very low dosage like .1 and then rachet it up.  I had a terrible reaction to .3 and had to go to the hospital because erection would not go away after 5 hours or so.  I did not know about the sudafed then but wish I had.  Enjoy.


 
PSA 4.7 August 2008
PSA 4.7 September 2008 retest
Biopsy late September 2008 6 of 12 positive and gleason 8
DiVinci radical laposcopy surgery November 3, 2008
Nerve spariing surgery.  left side not touched and right side partly disturbed
results of pathology report, cancer contained in capsule in one area
gleason reduced to 7
seminal vessicles and lymph nodes clear
regained full control of bladder with no leakage in about April 09
erections coming back in April 09 and improving
PSA January 09 <.1
PSA April 09 <.1
PSA July 09 <.1
 
 

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