Taxotere for HRPC at 35mg/m2 fortnightly

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panascope
New Member


Date Joined Mar 2010
Total Posts : 7
   Posted 3/8/2010 3:15 PM (GMT -6)   
I am on Taxotere fortnightly at 35mg/m2 for HRPC with mets to bones.

My PSA fell from 550 to 150 after nine infusions.

The usual dosage is 75mg/m2 every three weeks.

Is there anyone else here on my regimen?

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 3/8/2010 3:27 PM (GMT -6)   
Not too many here are dealing with hrpca advanced PCa, maybe a few. Are you also using Zometa for bone density or assistance, which is very commonly used along with this??? Have you already used or considered: ketoconazole, des, emcyt, estradiol patch to see if they are effective? Are you familar with www.hrpca.org
website and Howard Hansen?? You or others can find more answers there for such things.
There are others here that if you wanna talk shop or vent, etc., are very good at support and helpfulness.

(Dx 2002- I current use DES and have intermittently for like 4 + yrs.)


Youth is wasted on the Young-(W.C. Fields)


panascope
New Member


Date Joined Mar 2010
Total Posts : 7
   Posted 3/8/2010 4:48 PM (GMT -6)   
Had cryosurgery for PC in 1999. Started intermittent Zoladex in 2002. Mets to bones in 2007. Went hormone refractory in 2008. Tried Ketacanazole, Cyclophosphamide & DES, but the side effects were too great. Now on Taxotere.

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 3/9/2010 5:51 AM (GMT -6)   
Can you elaborate on how long keto might have worked and side effects you had and on DES usually the side effects are tenderness of boobs or enlargement of them which can be counter-acted, unless you are perhaps with high risk clotting factors or did not use coumadin blood thinner or such???? Curisous on that. What can you tell us about Cyclophosphamdie? Sorry to ask so much, but like the questions you have too, it is hard to find alot of examples and talk to enough people on such. Others can learn from such experiences or be informed on things that could be rather important along the journey.

Thanks.
Youth is wasted on the Young-(W.C. Fields)


panascope
New Member


Date Joined Mar 2010
Total Posts : 7
   Posted 3/10/2010 6:47 AM (GMT -6)   
Tried the Ketacanozole for 3 weeks. It lowered my PSA, but raised my liver enzymes to >500; felt like I was dying.

The DES took for just 2 days because it immediately exhausted me & made my breasts feel too painful.

The Cyclophosphamide was a component in a new PC drug called 'Hamsa' http://clinicaltrials.gov/ct2/show/NCT00684970
which I tried for 2 weeks, but felt just too over-medicated.

Post Edited (panascope) : 3/10/2010 4:52:40 AM (GMT-7)


Geebra
Regular Member


Date Joined May 2009
Total Posts : 476
   Posted 3/10/2010 7:15 AM (GMT -6)   
I was on Taxotere and Avastin as part of clinical trial for high risk localized PCa prior to surgery. Six cycles. Tumor shrunk about 30%, so did PSA. Side effects were quite tollerable.
Father died from poorly differentiated PCa @ 78 - normal PSA and DRE
5 biopsies over 4 years negative while PSA going from 3.8 to 28
Dx Nov 2007, age 46, PSA 29, Gleason 4+4=8
Decided to participate in clinical trial at Duke - 6 rounds of chemo (Taxotere + Avastin)
PSA prior to treatment 1/8/2008 is 33.90, bounced on 1/31/2008 to 38.20, and down at the end of the treatment (4/24/2008) to 20.60
RRP at Duke (Dr. Moul) on 6/16/2008, Gleason downgraded 4+3=7, T3a N0MX, focal extraprostatic extension, two small positive margins
PSA undetectable for 8 months, then 2/6/2009 0.10, 4/26/2009 0.17, 5/22/2009 0.20, 6/11/2009 0.27
ADT (ongoing, duration TBD): Lupron started 6/22/2009
Salvage IMRT to prostate bed and pelvis - 72gy over 40 treatments finished 10/21/2009
PSA 6/25/2009 0.1, T=516, 7/23/2009 <0.05, T<10, 10/21/2009 <0.05, T<10


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 3/10/2010 8:53 AM (GMT -6)   
That is weird that DES exhausted you, did you take more than 1-mg perhaps??? I have felt close to fantastic using DES for years, escpecially after doing ADT3 for 2 yrs. which was the pits, No more hot flashes, sweats, fatigue gone too, strength improved, and more. Perhaps it can react differently in some patients, like in your situation.
Youth is wasted on the Young-(W.C. Fields)

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