PSA sensitivity question--terminology

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compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7197
   Posted 3/13/2010 3:12 PM (GMT -6)   
I notice some of you report a PSA as <.1
Some have <.01
 
Mine was 0.01
Question: Would mine be the ultra-sensitive or super-sensitive one and the other the regular one?
 
I thought there was a PSA that went to 3 decimal places. Then what is that one called?
 
Mel

63 years old . PSA-- 3/08--2.90; 8/09--4.01; 11/09--4.19 (Free PSA 24%),  after 45 days on cipro! DREs have always been normal. PCA-3

Biopsy on 11/30/09. 5 out of 12 cores positive. Gleason 4+3. 2 cores were 3+3 (one 5% and the other 30%) on one side. On  other side:2 cores are 4+3 (5%)--1 core 3+4 (30%) no peri-neural invasion. prostate is 45 grams. Stage: T1C.  

Surgery with Dr. Menon at Ford Hospital, 1/26/10. He says all looked good. Spared nerves. Unfortunately: Pathology Report: G 4+3 (65%-35%). Cancer in 15% of gland. Lymph Nodes: Clear.  Perineural Invasion: yes. Seminal Vessical Involvement: No.  Extraprostatic Extension: yes.  Positive Margin: Yes-- focal-- 1 spot .5mm. Final Weight is 52.7 gms. 

 Incontinence: joined that club-- definite leaks—1 pad/day. Night is dry, was  using 1 pad at night for security, but pretty much dispensed with that most nights. Update: no pads at night. No pads while at home, but still very uncomfortable. Use 1 pad for out-of-house activities. Suddenly got MUCH better on 3/10/10, almost overnight. Still some urgency but no pads about 90% of the time.

Next Event: First post-op PSA on 3/10/10--DRUM ROLL: 0.01


Herophilus
Veteran Member


Date Joined Sep 2009
Total Posts : 657
   Posted 3/13/2010 3:51 PM (GMT -6)   
mine was ordered to be done as ultra-sensitive, an reported as 2 decimal places.
hero

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4088
   Posted 3/13/2010 3:56 PM (GMT -6)   
Mine always comes back <0.1
AGE:58, 57dx. PSA 5.4
Biopsy: 9/08 Gleason 3+4=7
open RP: 10?08 Nerve sparing. Path Report : GS 3+3=6 Stg pt2c margins clear
Cath for 10 day. Dry day after removal of Cath
PSA @ 3 months <0.1
6 months <0.1
9 months <0.1
12 months <0.1
16 months <0.1

ED Started VED at 3 months, pills followed VCL none did much, tried MUSE at 9 months (YUCK) Hated it. 15 months out injections Caveject (succecc)


Casey59
Veteran Member


Date Joined Sep 2009
Total Posts : 3172
   Posted 3/13/2010 3:59 PM (GMT -6)   

Standard PSA test has lower detection limit of 0.1ng/mL

Ultra-sensitive PSA test has lower detection limit of 0.04, 0.03 or most commonly 0.01 ng/mL, depending on the different assay used.

There is some new testing that goes lower; don't know the name of that one.


Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2457
   Posted 3/13/2010 4:34 PM (GMT -6)   
Mel,are
I had the ultra sensitive test and it came back .004. My understanding is that there 3 different PSA tests that produce 1, 2 or three digits after the decimal point.
Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm in circumference.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1
11.5 months test 1/21/10 result 0.004

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