Johns Hopkins say being obese is worse for PCa outcomes

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Sonny3
Veteran Member


Date Joined Aug 2009
Total Posts : 2448
   Posted 3/16/2010 12:53 PM (GMT -6)   
I know we don't like to cut and paste, but every time I try to send a link to these newsletters, folks have a tough time getting them to hook up.

Here is the salient point of the discussion;

In a study reported in the journal Cancer, obese men with a BMI of 35 or higher were somewhat less likely to be diagnosed with prostate cancer than were normal-weight men (BMI of less than 25). But if prostate cancer developed in these men, it was more likely to be fatal. During the five years of the study, men with a BMI of 35 or higher were twice as likely to die of their prostate cancer as were normal-weight men.

Results of another study reported in Cancer showed that obese men (BMI greater than 30) who had prostate cancer confined to the prostate or to areas surrounding it were three times more likely to develop metastatic cancer than were normal-weight men with a similar diagnosis. In this 10-year study, being obese more than doubled the risk of dying of prostate cancer.

Here is the link to the article just in case it works for you;

http://www.johnshopkinshealthalerts.com/alerts/prostate_disorders/JohnsHopkinsProstateDisordersHealthalert_3451-1.html?ET=johnshopkins_blog:e36822:548695a:&st=email&st=email&s=EPH_100316_005

Thought this might be good for a few conversations.

Personally, I am going against the grain of the study. At diagnosis I was 61 years old, 204 lbs, athletically fit with a BMI of 16%. Seems like my cancer has been somewhat aggressive regardless.

Sonny
60 years old when diagnosed
PSA 11/07 3.0
PSA 5/09 6.4
Diagnosis confirmed July 9, 2009
12 Needle Biopsy = 9 clear , 3 postive
Gleason Score (3+4) 7 in all positive cores
da Vinci 9/17/09
Post Surgery Pathology: GS 4+3=7
Stage: T3a
Tumor Volume 12.5%
positive margin, extra-prostatic extension
30 day PSA 0.4, 50 day psa 0.53, 64 day psa 0.6
IMRT completed 1/15/10 35 treatments- 70Gy

2/24/10 FIRST POST RAD PSA 1.1---CARRRP --waiting for the next test.


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4848
   Posted 3/16/2010 12:59 PM (GMT -6)   

And on the other hand - my BMI was horrible @ 55 or so....and my cancer is in check so to speak.

I'm 5'11" and hovering around 220 lbs. (age 55)

But, one Doc said that being 220 lbs and NOW a non-smoker is much better then 200 lbs and a smoker...

 



Sonny3
Veteran Member


Date Joined Aug 2009
Total Posts : 2448
   Posted 3/16/2010 1:06 PM (GMT -6)   
Steve,

You been talking to my wife? She has been riding my (now 184lb) butt to give up my daily 5 cigarettes for quite a while now. LOL

Sonny
60 years old when diagnosed
PSA 11/07 3.0
PSA 5/09 6.4
Diagnosis confirmed July 9, 2009
12 Needle Biopsy = 9 clear , 3 postive
Gleason Score (3+4) 7 in all positive cores
da Vinci 9/17/09
Post Surgery Pathology: GS 4+3=7
Stage: T3a
Tumor Volume 12.5%
positive margin, extra-prostatic extension
30 day PSA 0.4, 50 day psa 0.53, 64 day psa 0.6
IMRT completed 1/15/10 35 treatments- 70Gy

2/24/10 FIRST POST RAD PSA 1.1---CARRRP --waiting for the next test.


Sunbird
Regular Member


Date Joined Apr 2008
Total Posts : 140
   Posted 3/16/2010 1:15 PM (GMT -6)   
Honey,

Pass the yogurt.........
1996, Age 48, Stage III Colon Ca, Colon Resection followed by 18 chemo treatments.
 
2000, Colon Ca Metastasis to upper left lung lobe.  Lung lobe surgically removed.  24 chemo treatments scheduled.  Took 1, declined the rest.
 
9/08 PSA is 2.8, 12/08 PSA is 4.56??  Chalk it up to prostatitis due to urinary retention after Nissen Fundo Surgery.  VA docs prescribe 30 days of Septra.  Prostate feels normal.  PSA hovers around 4.1.  VA docs want prostate biopsy but can't seem to get me into the schedule.  Continue through Spring and Fall of 2009 thinking I have prostatitis.  Bacteria cultures are always neg.  PSA drops to 3.1 10/09.
 
12/09 Prostate Biopsy performed
3 of 10 cores positive, 5%, 25%, & 35%, 3 + 3= Gleason Six with perineural invasion.
 
Doc wants CT Scan due to prior Colon Ca. Findings: "The seminal vesicles are irregular & there is nodularity in the periprostatic fat such that local extension cannot be excluded.  Shotty lymph nodes in both groin measuring 2.3 cm."
 
Doc wants Endo-rectal MRI (OUCH!) Findings: Mild central zone BPH, no discrete focus of carcinoma is identified, no evidience of invasion into the periprostatic fat or seminal vesicles.  Normal size iliac chain lymph nodes.
 
2/08/10 Open RP surgery.  Findings: Gleason Six upgraded to Seven.  3 + 4, Stage pT2c, Bilateral w/perineural invasion, No pos lymph nodes,  margins uninvolved, no extraprostatic extension, no seminal vesicle extension,  39 grams, blood loss 1200 ml (didn't want a transfusion & didn't get one) nerve bundles spared bilaterally.  current age-61


Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2460
   Posted 3/16/2010 1:19 PM (GMT -6)   
I don't know how accurate this study is but if true, I'm happy with a BMI of 26.5.
Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm in circumference.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1
11.5 months test 1/21/10 result 0.004


60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 2243
   Posted 3/16/2010 1:21 PM (GMT -6)   
The BMI leaves a lot to be desired. At 6ft 185 pounds, athletic build my BMI according to Operative report was 25.5. So it really does not take muscle mass and body types into considertion, in my humble opinion. Still had a gleason 8 at the end. But having said that, obesity likely can never help any disease.
Michael
Dx with PCA 12/08 2 out of 12 cores positive 4.5 psa
59 yo when diagnosed, 61 yo 2010
Robotic surgery 5/09 Atlanta, Ga
Catheter out after 10 days
Gleason upgraded to 3+5, volume less than 10%
2 pads per day, 1 depends but getting better,
 started ED tx 7/17, slow go
Post op dx of neuropathy
T2C left lateral and left posterior margins involved
3 months psa.01, 6 month psa.4, 6 1/2 month psa.5
Starting IMRT on 1/18/10, Completed 39 tx at 72 gys on 3/12/10
Great family and friends
Michael


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4848
   Posted 3/16/2010 1:22 PM (GMT -6)   
Sonny - I bet you know that if you smoke - you're a smoker. Counting down from two packs a day to one pack a day does nothing for your healh...Might as well smoke both packsidea
 
On the other hand - I'm getting $1,500.00 worth of remolding work done on my master bath as we type - for FREE. Kind of free...Its from the money I've saved by not smoking in the last 7 months...And I have a lot left over too.
Age 55   - 5'11"   215lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


Sonny3
Veteran Member


Date Joined Aug 2009
Total Posts : 2448
   Posted 3/16/2010 2:12 PM (GMT -6)   
Steve, yeah I know, but if I drink one six pack every 2-3 weeks, should I hold to the same logic and drink 1 six pack a day. Just seems like I am getting a lot less niccotene and tar.

Besides I am on my way to none in the next week.

Sonny
60 years old when diagnosed
PSA 11/07 3.0
PSA 5/09 6.4
Diagnosis confirmed July 9, 2009
12 Needle Biopsy = 9 clear , 3 postive
Gleason Score (3+4) 7 in all positive cores
da Vinci 9/17/09
Post Surgery Pathology: GS 4+3=7
Stage: T3a
Tumor Volume 12.5%
positive margin, extra-prostatic extension
30 day PSA 0.4, 50 day psa 0.53, 64 day psa 0.6
IMRT completed 1/15/10 35 treatments- 70Gy

2/24/10 FIRST POST RAD PSA 1.1---CARRRP --waiting for the next test.


goodlife
Veteran Member


Date Joined May 2009
Total Posts : 2692
   Posted 3/16/2010 3:35 PM (GMT -6)   
On of the possible causes in the study was that obese men didn't go to the doctor as often, hence their PC was more advanced when discovered.

Sometimes studies don't tell us a lot.

As a higher BMI guy, guess I'll just have to wait and see. I really have a height problem. If I was 7 feet tall, I would have a much lower BMI, hence a less risk of aggressive PC.
Goodlife
 
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared, but carved up a little.
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks .
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)
5 month PSA <.03 (undetectable)
6 Month PSA <.01
1 pad a day, no progress on ED.  Trimix injection
No pads, 1/1/10,  9 month PSA < .01


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 3/16/2010 3:39 PM (GMT -6)   
I think it stands to common sense and logic in general, than being obese is worse for any health condition. Can't think of one that being obese would improve your situation. Unless, you were trying to survive on a lifeboat 1,000 miles from land. You might last longer than a skinny.

David in SC
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, Caths #13 & #14 same time, 3/6 Cath #13 out - 4 days


SubicSquid
Regular Member


Date Joined Oct 2009
Total Posts : 252
   Posted 3/16/2010 5:10 PM (GMT -6)   
Obesity definately compicates PCa. I have a huge gut which precluded me from getting DaVinci surgery. The doctor said they don't make extensions long enough for the tools yet to enable him to use the robot on me. My surgeon told me up front that the big gut would complicate things and it did. My surgery ended up being 6 hours long. My bladder and prostate were in a hard enough position to work on for a normal person, but my gut made the surgery even harder. The incision crosses over the fat fold where I sit down. A couple of staples in that area became infected - again probably from being fat. Also, obesity seems to increase the time it takes to get over incontinence. The extra weight of the gut on the bladder puts a lot of extra prssure on it. Bottom line, being obese is not good for any reason.
*Age 63, PSA July 2009 5.66
*Diagnosed July 2009, Biopsy: 2 of 12 cores positive, Gleason 3 + 5 = 8
*MRI and Bone Scan Negative.
*open Surgery October 22, 2009
*Prostate, both nerve bundles, seminal vessels, and lymph nodes removed during surgery.
*Post surgery Biopsy, Gleason 4 + 3; 2 positive margins
*Still slightly incontinant after 3 months - 1 pad per day (light). Dry at night. 1-2 trips to toilet.
*ED - Yes (will start Levitra possibly in January)
*30 day PSA (ultra-sensitive) .07
*90 day PSA (standard) <0.15
*01/10 - bladder neck stricture. opened during cysto exam. Cath #2 in for 5 days.
*IMRT/IGRT delayed until April pending 180 day PSA result
*03/01 - bladder neck stricture. Dilated during cysto exam. Cath #3 in place.
*03/11 - Bladder neck surgery. Cath #4 in place.
*03/15 - Cath #4 out. Time to wait and see.


BillSD
Regular Member


Date Joined Sep 2008
Total Posts : 143
   Posted 3/16/2010 5:40 PM (GMT -6)   
I've hired a fitness trainer to do my exercise for me. She tells me I am up to 5 miles a day. turn

Age 61 (59 @ Dx) PSA 4.4

Biopsy 5/15/08 Gleason (3+3=6)

Bone scan and pelvic CT: clear

HT - 2 mo Casodex, 3 mo Trelstar

RRP Surgery 9/15/08

Post-OP Gleason 3+4=7, Stage pT2c pN0 MX

SV, perineural margin, 18 lymph nodes, bladder neck: all carcinoma free

Perineural invasion & Distal Margin: Carcinoma present

IMRT adjuvant radiation (35 Treatments) Ended 1/27/09

PSA Tests: (10/08) (3/09) (7/09) (1/10): all <0.1


mvesr
Veteran Member


Date Joined Apr 2007
Total Posts : 823
   Posted 3/17/2010 10:06 AM (GMT -6)   
Hi Sonny3

Dr. Freedland did a similar study a couple of years ago with the same result. I don't know the site for this info but If you search Duke and obese prostate patients on the Duke web site or do the same search at MSNBC I did an interview with Dr. Freedland for MSNBC. I don't know know why they picked me when they were looking for a fat guy, go figure.

Mika
age at dx 54 now 57
psa at dx 4.3
got the bad news 1/29/07
open surgery Duke Medical Center 5-29-07
never more than 2 pads
ED is getting better
the shots work great, still can't give them to myself
two years of zero's
Retired again after 36 years February 1, 2010


ChrisR
Veteran Member


Date Joined Apr 2008
Total Posts : 831
   Posted 3/18/2010 10:25 AM (GMT -6)   

My dad has been obese for at least 20 years.  He had PCa Gleason 6 10 years ago and only had radiation.  His PSA is still below 1

 

 


Dx 42
Gleason 6 (tertiary score 0)
OPEN RP 10/08  Johns Hopkins
pT2 Organ confined Gleason 6
PSA Undetectable as of 10/15/09
Next PSA 10/15/2010

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