New research forces cancer cells to "grow old and die"

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BillSD
Regular Member


Date Joined Sep 2008
Total Posts : 143
   Posted 3/17/2010 6:09 PM (GMT -6)   
I'm contantly looking for new and promising therapies that may benefit us down the road. I found this Reuters article to be interesting, since cancer is the state where cells bypassing the normal "grow old and die" lifecycle. 
 
 
Bill in San Diego

Age 61 (59 @ Dx) PSA 4.4

Biopsy 5/15/08 Gleason (3+3=6)

Bone scan and pelvic CT: clear

HT - 2 mo Casodex, 3 mo Trelstar

RRP Surgery 9/15/08

Post-OP Gleason 3+4=7, Stage pT2c pN0 MX

SV, perineural margin, 18 lymph nodes, bladder neck: all carcinoma free

Perineural invasion & Distal Margin: Carcinoma present

IMRT adjuvant radiation (35 Treatments) Ended 1/27/09

PSA Tests: (10/08) (3/09) (7/09) (1/10): all <0.1


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25364
   Posted 3/17/2010 6:26 PM (GMT -6)   
Very interesting read, thank you Bill
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, Caths #13 & #14 same time, 3/6 Cath #13 out - 4 days


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4088
   Posted 3/17/2010 6:35 PM (GMT -6)   
Bill: Thanks for the post. I did see a news clip on this last wk on TV. Promising news I think.

Cajun Jeff
9/08 PSA 5.4 referred to Urologist
9/08 Biopsy: GS 3+4=7 1 positive core in 12 1 pre cancer core
10/08 Nerve-Sparing open radical
Surgery Path Report Downgrade 3+3=6 GS Stage pT2c margins clear

3 month: PSA <0.1
6 month: PSA <0.1
10 month:PSA <0.1
1 year: PSA <0.1
16 month:PSA <0.1

ED - Started Cialis at 3 months, tried all 3, 6 months added pump, 9 months Tried MUSE (YUCK) Bad experience.
1 year mark Found new Urologist visit was at 14th month post surgery
Started Injections, Caverject! (Success)
17 month: ED making improvements : Oral Meds gets me 85%


60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 2215
   Posted 3/17/2010 6:39 PM (GMT -6)   
Thanks Bill. You just know that one day there will be an incredible breakthrough in treating cancer. Hope it's in my lifetime.
Michael
Dx with PCA 12/08 2 out of 12 cores positive 4.5 psa
59 yo when diagnosed, 61 yo 2010
Robotic surgery 5/09 Atlanta, Ga
Catheter out after 10 days
Gleason upgraded to 3+5, volume less than 10%
2 pads per day, 1 depends but getting better,
 started ED tx 7/17, slow go
Post op dx of neuropathy
T2C left lateral and left posterior margins involved
3 months psa.01, 6 month psa.4, 6 1/2 month psa.5
Starting IMRT on 1/18/10, Completed 39 tx at 72 gys on 3/12/10
Great family and friends
Michael


Magaboo
Veteran Member


Date Joined Oct 2006
Total Posts : 1210
   Posted 3/17/2010 7:38 PM (GMT -6)   
Thanks for the heads up on this development. Keeps the hope alive. As long as the procedure effects only the cancer cells and not the rest of them :-). I'm old enough as it is :-)
All the best to you.
 
Magaboo

Born Sept 1936
PSA 7.9
-ve DRE
Gleason's Score 3+4=7, 2 of 8 positive
Open RP 28 Nov 06 (nerve sparing), Post op staging T3a
Gleasons still 3+4=7
Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; 3 days before Rad Start=0.1
Salvage RT completed (33 sessions - 66 Grays) on the 19th Dec., 08.
PSA in Jan., 09=0.05; July 09=<0.04; JAN 10=<0.04


IdahoSurvivor
Veteran Member


Date Joined Aug 2007
Total Posts : 1015
   Posted 3/18/2010 12:45 AM (GMT -6)   
Hi Bill,

Thanks for the post. I hope some of these new weapons prove effective and come to the market soon.

Best regards,

Barry
Surgery: Da Vinci; July 31, 2007; 54 on surgery day;
Pathology: PSA: 4.3; Gleason: 3+3=6; T2a; Confined to Prostate;
Post RP PSAs: 09/07 <0.04; 12/07 <0.04; 03/08 <0.04;
06/08 <0.04; 12/08 <0.04; 06/09 =0.06; 09/09 <0.04;
Latest PSA 12/09 =0.05


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 3/18/2010 4:03 AM (GMT -6)   
Thanks for posting such, we are all ears on what might be coming. Someday somebody is going to get wealthy with a break through(the best about free enterprise and unhindered efforts), we hope it is sooner than later, and we would (likely)go abroad if it were non-USA and works. Don't know if FDA is even 100% trustworthy and especially today, where Government is more suspect than ever.

My onco-doc believes the 'stem cells' are the ones that are surviving even through hormone therapies including estradiol patches, DES, emcyt (these even can cause direct apoptosis to PCa cells) that destroy alot of PCa cells, but never seems to get them all and there could be cases, contrary where maybe they did. Kind of seems logical as PCa cells seem to make a comeback and morph to higher resistance even through therapies.


Youth is wasted on the Young-(W.C. Fields)

Post Edited (zufus) : 3/18/2010 4:13:20 AM (GMT-6)


skeener
Regular Member


Date Joined Dec 2009
Total Posts : 214
   Posted 3/18/2010 2:10 PM (GMT -6)   

Good read.  Thanks for the link.

Skeener


Age:  63 
Biopsy: May 09 showed 2 of 12 cores positive for prostate cancer -- 1 at 5% and 1 at 25%.  Cancer indicated as non aggressive.  Gleason Score: 3+3.
RRP on Oct 23/09 in London, Ontario.  Excellent surgeon. 
7 Weeks Post Op -  The fears I had about bad things about the operation and recovery did not materialise except of course ED!!.  Otherwise, everything went very smoothly.  Incontinence not a problem.  Wear a pad when out just in case. Pain was never a problem.
Pathology:  Unremarkable 
First followup PSA and Visit: Feb 11/10 - 0.0.
 
Next PSA May
Next doctor's visit in 6 months      

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