Change in Trimex formula?

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Ricky2
Regular Member


Date Joined Dec 2009
Total Posts : 97
   Posted 3/20/2010 12:36 PM (GMT -6)   
The trimex injection are still not working to my satisfaction. I am up to 60 ml and have been using suggestions from members as to how to inject. (pumping before injection etc.). I still only get about 60-80% and it only last for about 15 min. I am calling my urn on Monday. Should I ask him to change my trimex formula? What other problems could there be? Has old willie died forever?

Ricky2
Age 70

PSA 5/2008- 3.6, PSA 7/2009- 6.1, retested 9/2009-5.1.
Biopsy 9/2009. 4 of 12 positive. Gleason 3+4=7
CT and bone scan negative.
Robotic De Vince Surgery 10/29/2009. 1 night in hospital. No pain. Cath out on 11/6
Pathology Report: Gleason score 3+4. Margins slightly involved <.1mm to .25mm. Perineural invasion present, stage pT2c. Tumor 18%. Seminal Vesicle - absent, Lymph Nodes 0 of 6.
Continence- first 4 weeks after cath out Dry at night, rest of time, bladder held nothing. 6-7 pads per day. as of 12/30 no pads most of time. almost dry except for a few drips. I keep doing Kegels.
ED. Started VED on 12/17/2009. Every other day for 15 min. Cialis .20 mm twice a week
PSA 02/08/2010 <.1
02/22/10 Trimex injection .2ml less than 50% just a little discomfort.


Worried Guy
Veteran Member


Date Joined Jul 2009
Total Posts : 3732
   Posted 3/20/2010 1:26 PM (GMT -6)   
There are different concentrations of Trimix. I'm not sure which you have. If you tell your Uro that you have gone up to .60 ml and still have no action he can bump up the concentration -if you are not already at the max.
Good luck, May the Force be with you.
Jeff
Married 34 years, DX Age 56. First routine PSA test on April 8, 09: 17.8. Start 2 weeks of Cipro to rule out protatitis. May '09 PSA: 22.6, 3 weeks later: PSA: 23.2.
Biopsy 6/10/09: 7/12 scores positive, 20%-70%, Gleason 6=3+3. Bone and C/T scans neg.
RP DaVinci -7/21/2009 @ Univ of Roch Medical Center
Left nerve gone, right partial spared.
Catheter removed - 7/31/2009 Pathology report received:
Gleason 3+4=7, Tumor size: 2.5 x 1.8 cm, location: both lobes and apex.
Extraprostatic extension present; Perineural invasion: present, extensive.
No Malignancy in Seminal Vesicle, vasa deferentia, lymph nodes 0/13
Prostate mass 56 grams. Pathologic Stage: pT3aN0MX
Post Surgery Status:
Potency - 12/11 5 months, Still no activity, zip. Using pump daily since 11/11. No effect with 20 mg of Cialis or 100 mg of Viagra. Shots next See Uro 1/22/10 Trimix #1. Try 0.08- 25%, 0.12-25%, 2/26/10 try 0.16 First Success! 90%.
Incontinence - 8/20 4 full pads per day
.. 9/7 3-4 full pads per day (Try cutting down on fluids. Bad idea. I know.)
12/11 5 months: Still 3 pads per day. 400-450ml/day
2/26/10 7 months: Still 3 pads but leak is now 320 ml (5 day avg.)
Post Surgery PSA - 9/3 6 weeks - 0.05; 10/13 3 months - 0.04, 1/14 6 months - 0.05.


apacker1950
Regular Member


Date Joined Nov 2008
Total Posts : 122
   Posted 3/20/2010 2:20 PM (GMT -6)   
I tried pumping before injecting and had the same results you mention.  I have the best results by just injecting and then rolling Mr. Happy like dough in the palms of my hands briskly for a few seconds to distribute the trimix well.  I have very few failures this way.  I've learned through this forum that we all react differently and what works for one may or may not work for another.  I hope you can find a routine that is successful for you.
 
Good luck,
 
Allan
Dx PCa age 54. Jly 05- PSA 8.1 Sept 05- PSA 10.7
Sept 05- Biopsy  9 of 12 cancerous, Gleason 3+3=6, T2
Bone scan and cat scan showed hot spot on hip bone.
Oct 05- bone biopsy, ouch.  benign , no cancer in bones.
Nov 05- PSA 15.4 Nov 18, 05- Nerve sparing open RP at Huntsman Cancer Center, by Dr. Robert Stevenson. 100% continence at 3 months. ED- Tried the big 3 pills with no results. Feb 06-Started VED, worked, but painful with constriction rings. May 06 started Trimix injections.
ED appears to be perminant but doing great with Trimix.
PSA remains undetectable.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 3/20/2010 4:41 PM (GMT -6)   
I suppose the literature says the 'standard' ratio is 30mg/ml papaverine/1mg/ml phentolamine/20mcg/ml alprostadil. What changes you have from that I don't know. Unless your formula is much weaker (I've seen some quoted here that were- especially in the alprostadil) then your doc should know how to adjust. I'd suggest you tell him what the 'standard' is and ask what he is prescribing, and if different, ask him to reevaluate the conditions and try a stronger dose, whatever that may be.
James C. Age 62
Co-Moderator- Prostate Cancer Forum
Gonna Make Myself A Better Man: www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
32 mts: PSA's: .04 each test since surgery, ED Continues-Bimix .3ml PRN or Trimix .15ml PRN


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 3/21/2010 12:43 PM (GMT -6)   
could you tell us what the concentration is of the 3 drugs


I know I have heard of people with 1/2 strength Trimix, Perhaps your Uro started you off on 1/2
Stats:
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function


Redman55
Regular Member


Date Joined Jan 2010
Total Posts : 87
   Posted 3/21/2010 3:59 PM (GMT -6)   
I am at .35 ml trimix, but I also go with an ed generic called eregra 100mg. which provides very consistent results and I actually may start to reduce the dosage as I am only 4 months out of surgery and am seeing mild reaction from just 100 mg ed pill alone; but not enough to handle the Indy 500. You may want to try combiningwith ed pill as long as you had at least a nerve bundle spared. I was told I could go as high as .7 trimix, then if inadequate then they would alter the blend. I have the standard trimix blend.
Age 54
PSA 8/2009 5.6 Gleason 8
DaVinci surgery 11/2009
Pathology - totally contained in margins -one bundle spared
PSA now undetectable at < .05
Continance: 1 pad and almost normal
Doing 3 P's and now using trimix


Ricky2
Regular Member


Date Joined Dec 2009
Total Posts : 97
   Posted 3/21/2010 11:07 PM (GMT -6)   
The Trimex blend I have is Papaverine 30 mg/ml, Phentolamine 0.5 mg/ml & Prostaglandin E 10 MCG/ML. It seems that Phentolamine and Prostaglandin is lower than the "standard" dose. I believe that Prostaglandin is the drug that gives the biggest kick.

Ricky
Age 70

PSA 5/2008- 3.6, PSA 7/2009- 6.1, retested 9/2009-5.1.
Biopsy 9/2009. 4 of 12 positive. Gleason 3+4=7
CT and bone scan negative.
Robotic De Vince Surgery 10/29/2009. 1 night in hospital. No pain. Cath out on 11/6
Pathology Report: Gleason score 3+4. Margins slightly involved <.1mm to .25mm. Perineural invasion present, stage pT2c. Tumor 18%. Seminal Vesicle - absent, Lymph Nodes 0 of 6.
Continence- first 4 weeks after cath out Dry at night, rest of time, bladder held nothing. 6-7 pads per day. as of 12/30 no pads most of time. almost dry except for a few drips. I keep doing Kegels.
ED. Started VED on 12/17/2009. Every other day for 15 min. Cialis .20 mm twice a week
PSA 02/08/2010 <.1
02/22/10 Trimex injection .2ml less than 50% just a little discomfort.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 3/22/2010 10:14 AM (GMT -6)   
Rickey, yes it appears the phento and prostaglandin are both half strength to the 'standard'. And yes, the prostaglandin (alprostadil) does give it a kick. If it were me, and I could afford it, I'd ask for the standard prescription and try that. At the least, with double strength, maybe it would only take half as much and be a money saver... smilewinkgrin
James C. Age 62
Co-Moderator- Prostate Cancer Forum
Gonna Make Myself A Better Man: www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07 PSA 7.6, referred to Urologist, recheck 6.7
7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS 3/3=6
9/07 Nerve sparing open RRP 110gms.- Path Report: GS 3+3=6 Stg. pT2c, 110gms, margins clear
32 mts: PSA's: .04 each test since surgery, ED Continues-Bimix .3ml PRN or Trimix .15ml PRN


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 3/22/2010 8:40 PM (GMT -6)   
Ricky,

The problem is the 1/2 strength Trimix. Here's why

The penis can only absorb so much fluid , At 60ml you are asking it to absorb a lot, most of it will be dissipated back into your body

That means that the amount that does stay in the penis is not full strength

For arguments sake lest say the penis can hold 40ml of an injected liquid. Your 60ml is not only resulting in a waste of 20ml but the 40ml that is absorbed is less than optimum

Now take full strength Trimix, you likely will only need 20-25 units which seems to be the max for most people here, some take even less. Those absorbed 20-25 units have a far greater concentration of potent drug than the 60 units of half strength

Basically it would be cheaper to buy full strength Trimix, using 20-25units per shot, vs 60 units of 1/2 strength Trimix ( which does not work )

60 units gets you what 8 shots per 5ml vial ?
going full strength at 25 units will net you 20 shots per 5ml vial

I doubt the cost diff is all that much between the 2, a good part of the Trimix cost is the freezer packs and overnight s/h, which either dosage would require
Stats:
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function

New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, July 16, 2018 1:40 PM (GMT -6)
There are a total of 2,982,060 posts in 326,960 threads.
View Active Threads


Who's Online
This forum has 161806 registered members. Please welcome our newest member, jjmcd123.
443 Guest(s), 11 Registered Member(s) are currently online.  Details
Nick_69, Johnny Boy, Gemlin, Max89, Admin, Girlie, sierraDon, InTheShop, Y o g i, Tall Allen, iPoop