chemo and lupron

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mgl
Regular Member


Date Joined Feb 2007
Total Posts : 122
   Posted 3/27/2010 7:35 AM (GMT -6)   
has any one had a low grade chemo treatment combined with lupron to treat PC after surgery and radiation ?
50 years old
gleason 3+4=7 psa5.8 clinical stageT3a
Da vinci surgery April10 2007 Mayo clinic Rochester, Mn.
extraprostatic extension Gleason -same
pelvic lymph nodes -negative
Catheter out April 19
psa aug 2007 0.28
37 treatments IMRT ended 10/26/07
psa Jan 29 2008 0.10
psa april 30 0.14
psa aug 21, 0.16
psa dec 17 o8 , 0.16
psa apr 09, 0.21
psa aug 09, 0.26


Piy
Regular Member


Date Joined Mar 2010
Total Posts : 145
   Posted 3/27/2010 8:08 AM (GMT -6)   
Not sure if it would be considered low grade or not, but my husband had chemo 1 day a week, 3 weeks on 1 week off for 5 months in combination with Lupron.  He is on the Leibowitz protocol.

Dx June 2007 - age 48
RRP October 2007
75% of prostate involved
Gleason 9
Positive margin
Scans clear
No mets
SRT - February 2008
PSA - Mar 09-0.4 / Jun 09-0.7 / Aug 09-1.7 / Feb 10-.008
Commenced Dr. Robt Leibowitz "Triple Hormone Blockade" protocol in August 2009
Completed chemo Dec 28 2009


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 3/27/2010 8:10 AM (GMT -6)   
You can find the answer to that and similar questions at a specialized group for advanced patients with PCa.

www.hrpca.org  (with the the text page, see 'on-line support lists' has a tab to sign up to group and then you can pose and answer questions, this is for people around the world, so it can get very interesting as to what protocols are being done here and abroad, and what some patients journies look like. They have the group through (Yahoo groups, maybe try searching HRPCa there also) Howard Hansen is moderator and 17 yr. fighter on PCa.

I would guess Howard knows of someone whom has done such. I know of a patient whom did this more bizarre protocol and last I heard did well with it:
Chemo (1st) then Brachy + IMRT radiations (this is very unusal as far as I ever heard of). It was done I believe in Oregon/Washington area back around 2002-2004 era for this patient.

The Leibowitz protocol...could be different as mentioned above...that is not the protocol he famous or infamous for, that one is based upon: (ADT3 being composed of these types)  Duration usually 13 months, then only proscar for maintenance.

Lupron (zoladex or similar) + casodex (maybe higher dosage than average)+ proscar (or avodart)...this is the one most people heard of.


Youth is wasted on the Young-(W.C. Fields)

Post Edited (zufus) : 3/28/2010 4:18:17 AM (GMT-6)


Piy
Regular Member


Date Joined Mar 2010
Total Posts : 145
   Posted 3/27/2010 8:21 AM (GMT -6)   
Just to clarify, my husband is not just on the Leibowitz protocol.  Dr. Robert Leibowitz is his physician.  The 3-prong protocol combines chemotheraphy, hormone theraphy and the anti-angiogenic "cocktail" as well as numerous supportive supplements.

Dx June 2007 - age 48
RRP October 2007
75% of prostate involved
Gleason 9
Positive margin
Scans clear
No mets
SRT - February 2008
PSA - Mar 09-0.4 / Jun 09-0.7 / Aug 09-1.7 / Feb 10-.008
Commenced Dr. Robt Leibowitz "Triple Hormone Blockade" protocol in August 2009
Completed chemo Dec 28 2009


Geebra
Regular Member


Date Joined May 2009
Total Posts : 476
   Posted 3/27/2010 8:45 AM (GMT -6)   
When I was diagnosed they offered two clinical trials to me. One stage two was a chemo plus Avastin, the other was stage three trial of chemo and HT. I chose the former, because I did not want to risk being in control group for stage three trial. However, the results of stage two trial for chemo plus HT were impressive, with two people showing no signs of cancer when the finally did the prostatectomy. The Taxotere regiment was a little different. One treatment every three weeks for six cycles.
Father died from poorly differentiated PCa @ 78 - normal PSA and DRE
5 biopsies over 4 years negative while PSA going from 3.8 to 28
Dx Nov 2007, age 46, PSA 29, Gleason 4+4=8
Decided to participate in clinical trial at Duke - 6 rounds of chemo (Taxotere + Avastin)
PSA prior to treatment 1/8/2008 is 33.90, bounced on 1/31/2008 to 38.20, and down at the end of the treatment (4/24/2008) to 20.60
RRP at Duke (Dr. Moul) on 6/16/2008, Gleason downgraded 4+3=7, T3a N0MX, focal extraprostatic extension, two small positive margins
PSA undetectable for 8 months, then 2/6/2009 0.10, 4/26/2009 0.17, 5/22/2009 0.20, 6/11/2009 0.27
ADT (ongoing, duration TBD): Lupron started 6/22/2009
Salvage IMRT to prostate bed and pelvis - 72gy over 40 treatments finished 10/21/2009
PSA 6/25/2009 0.1, T=516, 7/23/2009 <0.05, T<10, 10/21/2009 <0.05, T<10


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 3/27/2010 9:38 AM (GMT -6)   
The new chemo drug that is under FDA approval right now called Cabazitaxel (reports coming in May-in phase III right now), shows some survival benefit in months(sounds like nothing but it is an averages thing and in some that could be many months or longer)and also mentioned from Journal article can tolerate 6 cycles unlike the naovantrone group that tolerated only four...may be better somewhat for the patient.    Tannock et al. J Clin Oncol. 1996; 14: 1756-1764 if wish to read about such.


Youth is wasted on the Young-(W.C. Fields)

Post Edited (zufus) : 3/28/2010 4:20:26 AM (GMT-6)

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