PSA testing after SRT

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Regular Member

Date Joined Feb 2008
Total Posts : 25
   Posted 3/27/2010 7:45 AM (GMT -6)   
How long after completion of SRT is it safe to make a conclusion if the therapy has been a sucess or not.
Also what is the average time for the first psa test after treatment.
diagnosed pc Nov 2007 after small lump
found during routine examination
gleason 7 (3+4 ) psa 4.6.
Da Vinci Jan 2008.
post op pathology report gleason 7 (4+3)
positive margin right side nerves spared.
no incontinence problems.
ed is a problem.
psa 3 weeks post op .5
psa three months post op .3
wait and watch possible rt.

Veteran Member

Date Joined Nov 2008
Total Posts : 696
   Posted 3/27/2010 8:29 AM (GMT -6)   
I have in my notes that statistically the ones who do the best are the men who see their PSA decline to less than 0.1 within 9 months from the end of SRT. I can't find my source on that, however, so I could be wrong. I thought it was Stephenson who showed that, but looking at his 2004 and 2007 articles on salvage, I can't find that fact. I do know that it is normal for PSA to be greater than or equal to 0.1 for several months after SRT, even in men who will have durable responses.

Catalona and colleagues found that at 10 years, overall, only 25% of patients were free from PSA progression. However, those who were responders (saw their PSA drop to an undetectable level) did better. 35% of those men were free from PSA progression. Source:

I think you have to be followed for a long, long time to truly be able to say it worked and you're cured. The curve is still there 6 years after end of treatment, and men are still falling off that curve. Catalona's single-center study going out 10 years is the longest study I know of. I think if I make it to 10 years with no progression, I will be almost sure I'm cured. If I make it to 6 years, I'll be cautiously optimistic. Right now, speaking for myself, I am in a wait and see mode

3 month testing after SRT is normal. At least, that's what I had. After a while, as my PSA was less than 0.1, we switched to 6 month checkups. That's where I am now, just over 3 years out.

Best wishes.

Dx Feb 2006, PSA 9 @age 43
RRP Apr 2006 - Gleason 3+4, T2c, NX MX, pos margins
PSA 5/06 <0.1, 8/06 0.2, 12/06 0.6, 1/07 0.7.
Salvage radiation (IMRT) total dose 70.2 Gy, Jan-Mar 2007@ age 44
PSA 6/07 0.1, 9/07 and thereafter <0.1

English Alf
Veteran Member

Date Joined Oct 2009
Total Posts : 2209
   Posted 3/27/2010 9:13 AM (GMT -6)   
I am due to start SRT sometime in April and they have told me that my next PSA test will be three months after RT finishes.

Regular Member

Date Joined Oct 2007
Total Posts : 300
   Posted 3/27/2010 9:49 AM (GMT -6)   
My first PSA test after SRT was 3 months. The PSA was the same as pre-treatment, however at 6 months out it was 0.00. I agree with Galileo on the time frame.
Age 65
Diagnosed 10/12/07
PSA 6.3
Biopsy 18 core samples, 2 positive <5%
Stage T1a Gleason 6 (3+3)
LRP  1/29/08
Gleason 7 (3+4)
1 positive margin (.3cm)
4/16/08- Started Bi-mix injections 
5/15/08- 1st Post-Op PSA 0.07 Undetectable
8/11/08 -2nd Post-OP PSA 0.02 Undetectable
8/15/08- No more pads as of today  Whoopee!!!
11/13/08- 3rd post-op PSA 0.02 Undetectable
03/02/09- 1 yr. post-op PSA .09 Undetectable
05/13/09   PSA .18 (ouch)
Started IMRT June 13, 2009
Completed 37 treatments July 31, 2009 (66.6gy)
11/23/09 Post IMRT PSA .18
2/12/10   Post IMRT PSA 0.00

Veteran Member

Date Joined Oct 2006
Total Posts : 1210
   Posted 3/27/2010 10:40 AM (GMT -6)   
I had my first PSA test 6 weeks after completion of the SRT. The Onc wanted to see 'some' PSA reduction at that time. He did. Then continue testing every 6 month for a few years. I'm at 15 month and thus far things look hopeful.
All the best to you.

Born Sept 1936
PSA 7.9
-ve DRE
Gleason's Score 3+4=7, 2 of 8 positive
Open RP 28 Nov 06 (nerve sparing), Post op staging T3a
Gleasons still 3+4=7
Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; 3 days before Rad Start=0.1
Salvage RT completed (33 sessions - 66 Grays) on the 19th Dec., 08.
PSA in Jan., 09=0.05; July 09=<0.04; JAN 10=<0.04

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