Trimix Injections Increase Risk of Perones?

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S Mark
New Member

Date Joined Nov 2008
Total Posts : 12
   Posted 4/7/2010 7:38 PM (GMT -6)   
I have been injecting Trimix (.5) with very little result.  One thng that has happened is that I now have Perones Disease.  Can the injections cause the disease?  Have started taking Vitamin E 400 IU per day, so far no improvement.  Anyone have similar problems and find a solution?  Thanks.
Age 58   - 6'2"   190lbs
Overall Heath Condition - Good
PSA - July 2006 & Jan 2007 -> 14.3
Biopsy - 03/04/07 -> Gleason 6 
05/03/07 - RRP
Catheter 5 weeks
(Both nerve bundles supposedly saved)
Post RRP PSA's <0.1

Regular Member

Date Joined Oct 2009
Total Posts : 103
   Posted 4/7/2010 9:16 PM (GMT -6)   
I was told trimix injections have a 5% chance of causing peronies and that it is usually caused by using the same injection site. I was told to alternate between 4 different spots to help potentially avoid it.
Age 40
Pre-op PSA was 5.8 from wellness test on May 19, 09
Follow up test from uro was 4.6 with a 9.3% free psa
Gleason 3+3 in one core, 3+4 in second core of 12 samples taken
Surgery performed August 19th, 09.
One side nerves spared. Nerve graft on other side.
Six weeks incontinence almost over. ED a work in progress but seeing some response.
4 months no longer using pads. ED using trimix with positive response.
Post op October 2nd, 2009 All margins were negative. PSA results in a few days.
Post op pathology 3+4 PT2A NOMO
6 wk PSA .004
3 month PSA .003 12-18-09
6 month PSA .003 3-17-10

Veteran Member

Date Joined Jul 2006
Total Posts : 686
   Posted 4/7/2010 11:31 PM (GMT -6)   

I have been using BiMix injections for more than two years.  I continue to have excellent results.  However, over time, I have begun to develop some plaque build up.  It is a form of Peyronies disease, however in my case, it is on the sides of the penis rather than the usual top.  Because of that it is not painful or extreme and does not interfere with intercourse.

Studies do indicate that for some men who use injections there is a greater likelyhood that they will develop this plaque.  In my case it has not gotten any worse over the past year and half.  I hope that I will be able to continue the BiMix shots for many years to come.  I am aware of the plaque build up and worry about it, but so far it has not been a major problem.

PSA up to 4.7 July 2006 , nodule noted during DRE
Biopsy 10/16/06 ,stageT2A
Very Aggressive Gleason 4+4=8  right side
DaVinci Surgery  January 2007
Post op confirms gleason 4+4=8 with no extension or invasion
no long term continence problems
Post surgery PSA continues to be "undetectable"
One side nerves spared
Bi-Mix for ED 
born in 1941

Veteran Member

Date Joined Apr 2008
Total Posts : 847
   Posted 4/8/2010 5:14 AM (GMT -6)   
I used Bimix for about 18 months -- until I noticed a slight bend to the left, and some little bumps on the sides around my injection sites. I assumed that this was the plaque or scarring.

This was sufficient to induce me to give up Bimix. Although I got consistently good results with the injections, I never really got used to them "down there", so that was a second reason to give up. I now use only the pump and after practise, find that to be good enough.
Age 63 at diagnosis, now 64.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores.
Non-nerve sparing RRP on 7 March 2008.
Two nights in hospital; catheter out after 7 days.
Continent; no pads needed from the get-go.
Pathology showed organ confined and negative margins. Gleason downgraded to 4+4=8.
6-week : <0.05
7-month: <0.05
13-month: 0.07 (start of a trend?)
19-month: 0.09 (maybe)
After a learning curve, Bimix injections (0.2ml) worked well. From 14 months, occasional nocturnal erections. Have "graduated" to just the pump.

Veteran Member

Date Joined Aug 2007
Total Posts : 1015
   Posted 4/8/2010 11:21 AM (GMT -6)   
Yes. There is a risk for Peyronie's (correct spelling) with injections. There will be scar tissue build up.

My doctor suggests that you limit the injections to twice per week and alternate injection sites from right to left.

As in all other cases, every person's body is different and will react in different ways.

All the best,

Surgery: Da Vinci; July 31, 2007; 54 on surgery day;
Pathology: PSA: 4.3; Gleason: 3+3=6; T2a; Confined to Prostate;
Post RP PSAs: 09/'07 <0.04; 12/'07 <0.04; 03/'08 <0.04;
06/'08 <0.04; 12/'08 <0.04; 06/'09 =0.06; 09/'09 <0.04; 12/'09 =0.05;
Latest PSA 3/'10 <0.04

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