18 Month PSA...Not exactly what I expected

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LV-TX
Veteran Member


Date Joined Jul 2008
Total Posts : 966
   Posted 4/9/2010 9:08 AM (GMT -6)   
Nurse just called to give me the results of my 18 month test....     0.19
 
Little higher than I expected based on the previous trends I had.  Will wait for the doctor to call me later.  But it looks like a recurrence from the positive margin I had and a solid chance that it will be local.  So a little mopping up with some radiation appears to be coming in the months ahead.
 
Dale...hold my zero club membership...as the California gov would say...."I'll be back..."
You are beating back cancer, so hold your head up with dignity
 
Les
 
Age 58 at Diagnosis
Oct 2006 - PSA 2.6 - DRE Normal
May 2008 - PSA 4.6 - DRE Normal / TRUS normal
July 2008 - Biopsy 4 of 12 Positive 5 - 30% Involved Bilateral w/PNI - Gleason (3+3)6 Stage T1C
Robotic Surgery Sept 18, 2008
Pathology October 1, 2008 - Gleason 7 (3+4) Staged pT2c NO MX - Gland 50 cc
Seminal Vesicles and Lymph Nodes clear
Positive Margins Right Posterior Lobe
PSA 5 week Oct 2008 <.05
                   3 month Jan 2009     .06
                   6 month Apr 2009     .06
                   9 month Jul  2009     .08
                 12 month Oct 2009     .09 
                 18 month April 2010   .19


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4829
   Posted 4/9/2010 9:14 AM (GMT -6)   
Darn Les - sorry to hear this. Keep us posted.
Age 55   - 5'11"   215lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 4/9/2010 9:30 AM (GMT -6)   
Les, sorry to hear the latest results. Hopefully your plan will wipe it out.... I'm sure there will be a retest to make sure before pulling the trigger. Maybe it can be a fluke..
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 10 gms., margins clear
32 Months: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


BoisePSABantam
Regular Member


Date Joined Apr 2009
Total Posts : 20
   Posted 4/9/2010 9:43 AM (GMT -6)   
The moderator is right - they'll retest. However, if it's above 0.1, they'll want to radiate the pelvis. The treatment these days is good, and if you hit it early and hard you'll be OK. This is VERY common. So common in fact that I'm enrolling in a clinical trial to see what works best for recurrence.

I'm getting set up for radiation or radiation + HT in the next few weeks (depends on the clinical trial). But, the outlook is good for at least a long term remission. All I can ask for.

good luck
Pre-Surgery PSA: 4.92
age: 45 at DX.
DaVinci 5/07
1st PSA 0.07 8/07
2nd PSA 0.04 11/07
3rd PSA 0.04 02/08
4TH PSA 0.04 7/08
5th PSA 0.08 2/09
6th PSA 0.08 5/09
7th PSA 0.07 9/09
8th PSA 0.13 3/10


Sleepless09
Veteran Member


Date Joined Jul 2009
Total Posts : 1267
   Posted 4/9/2010 10:31 AM (GMT -6)   
Bummer, Les, but whacking it with the radiation offers cure and cure is the "C" word us cancer folk love to hear.

Keep us posted,

Sheldon AKA Sleepless
Age 67 in Apil '09 at news of 4 of 12 cores positive T2B and Gleason 3 + 3 and 5% to 25% PSA 1.5
Re-read of slides in June said Gleason 3 + 4 same four cores 5% to 15%
June 29 daVinci prostatectomy, Dr. Eric Estey, at Royal Alexandra Hospital Edmonton one night stay
From "knock out" to wake up in recovery less than two hours.  Actual surgery 70 minutes
Flew home to Winnipeg on July 3 after 5 nights in Ramada Inn  ---  perfect recovery spot!
Catheter out July 9
Final pathology is 3 + 4 Gleason 7, clear margins, clear nodes, T2C, sugeron says report is "excellent"
First post op PSA Sept 09  less than 0.02
PSA on Oct 23 test again less than 0.02
PSA on Jan 8 less than 0.02  
Oct 1st 09 -- dry at night, during day some stress issues.
Oct 31st padless 24/7 
Feel free to email me at:  sheldonprostate@yahoo.com    


Magaboo
Veteran Member


Date Joined Oct 2006
Total Posts : 1210
   Posted 4/9/2010 10:49 AM (GMT -6)   
Hi Les,
 
Sorry to read about your increasing PSA level. I too had an occurrence which started about 2 years ago and I had the SRT late in 2008. Fairly uneventful with only minor side effects. Starting SRT as early as possible is supposed to have the best chance of a positive outcome.
Wishing you all the best on your journey.
 
Magaboo


Born Sept 1936
PSA 7.9
-ve DRE
Gleason's Score 3+4=7, 2 of 8 positive
Open RP 28 Nov 06 (nerve sparing), Post op staging T3a
Gleasons still 3+4=7
Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; 3 days before Rad Start=0.1
Salvage RT completed (33 sessions - 66 Grays) on the 19th Dec., 08.
PSA in Jan., 09=0.05; July 09=<0.04; JAN 10=<0.04


Red Nighthawk
Regular Member


Date Joined Oct 2009
Total Posts : 289
   Posted 4/9/2010 11:02 AM (GMT -6)   
Les,
You have a very strong and positive attitude, and that will go a long way to a total cure. Get back to the club ASAP.
Age: 62
Pre-op PSA: 4.1
Post-op pathology:
Gleason grade: 3+4=7, present in both lobes, at least 1.1 cm, and occupying less than 5% of prostate by volume. pT2c NX MX
No lymphatic/vascular invasion present.
Seminal vesicles and extraprostatic soft tissue free of tumor.
Inked margins are free of tumor.
High grade prostatic intraepithelial neoplasia is present
Robotic RP: Sept. 15th, 2009 1 day in hospital, cath out on 9th day
Post-op PSA: at 4 weeks ---> .04
three months -> .03 (the trend is my friend!)
ED: Improvement is very slow but there are positive signs. Doc has NOT put me on ED drugs yet.
One pad/day for the first six weeks. Two pairs of underpants, just to play it safe, for a few months.
Surgery: Dr. Jim Hu. Brigham & Women's Hospital, Boston


skeener
Regular Member


Date Joined Dec 2009
Total Posts : 214
   Posted 4/9/2010 11:22 AM (GMT -6)   

Les

Wishing you the best.

Skeener


Age:  63 
Biopsy: May 09 showed 2 of 12 cores positive for prostate cancer -- 1 at 5% and 1 at 25%.  Cancer indicated as non aggressive.  Gleason Score: 3+3.
RRP on Oct 23/09 in London, Ontario.  Excellent surgeon. 
7 Weeks Post Op -  The fears I had about bad things about the operation and recovery did not materialise except of course ED!!.  Otherwise, everything went very smoothly.  Incontinence not a problem.  Wear a pad when out just in case. Pain was never a problem.
Pathology:  Unremarkable 
First followup PSA and Visit: Feb 11/10 - 0.0.
 
Next PSA May
Next doctor's visit in 6 months      


tatt2man
Veteran Member


Date Joined Jan 2010
Total Posts : 2842
   Posted 4/9/2010 11:46 AM (GMT -6)   
Les - sorry to see the numbers rise - sending you via email the book from princess margaret hospital and their nutritional approach during treatment -
major hugs
BRONSON
.................
Age: 54 - gay - with common-law spouse of 13 years, Steve - 60
PSA: 04/2007- 1.68 - 08/2009 - 3.46 - 10/2009 - 3.86
Confirmation of Prostate Cancer: October 16, 2009 - 6 of 12 cancerous samples , Gleason 7 (4+3)
Doctor: Dr. Mohamed Elharram -Urologist / Surgeon - Peterborough Regional Health Centre
Radical Prostatectomy Operation: November 18, 2009 , home - November 21, 2009
Post Surgery Biopsy: pT3a- gleason 7 - extraprostatic extension - perineural invasion - prostate weight - 34.1gm -
ED Prescription: Jan 8/2010 - started daily 5mg cialis - girth back to normal -but not much length - will go for trimix in April when I see doc
Incontinence: Feb 2010- 3-5 pads/1-2 clothes changes/day- March 3, 2010 - week 14 after surgery -finally seeing improvement - March 29- incontinence better - 1-2 pads a day - one pad at night
location: Peteborough, Ontario, Canada
Post Surgery-PSA: - April 8, 2010 - 0.05 - I am in the ZERO CLUB - hooorah!
............


LV-TX
Veteran Member


Date Joined Jul 2008
Total Posts : 966
   Posted 4/9/2010 12:13 PM (GMT -6)   
Hey Steve...my good neighbor...thanks I keep in touch

James and Boise...yeah, I figure there will be a retest in the next couple of months. I was figuring on just slightly over the .1 mark as I know my uro was expecting the same. We talked about the slight increases over the last year and he felt it was pretty insignificant at the time and just needed to be watched. So we'll see what happens next.

Sleepless and Magaboo...thanks guys...with my stats it is probably local in which the radiation will zap it. Unfortunately my only fear is where the margin was. My uro spent several hours during surgery to prevent damage to the rectal wall and if this is where the cancer is, then radiation may cause some issues. But I will address those concerns with the radiation guy.

Thanks Red and Skeener...everyone here is a great bunch to be associated with

Bronson...my man..thanks for the email. I can't completely read it right now but certainly will over the weekend. I have been taking high doses of NSAIDS which was suppose to suppress the cancer from creating blood vessels for survival. I thought during the last year that it was doing a pretty good job, until this lastest test. Guess the cancer cells figured a way to stay alive.

Haven't heard back from the doc yet, and probably won't until next week. He performs surgery on Thursdays and makes his hospital rounds on Fridays.

Again thanks to all the support
You are beating back cancer, so hold your head up with dignity
 
Les
 
Age 58 at Diagnosis
Oct 2006 - PSA 2.6 - DRE Normal
May 2008 - PSA 4.6 - DRE Normal / TRUS normal
July 2008 - Biopsy 4 of 12 Positive 5 - 30% Involved Bilateral w/PNI - Gleason (3+3)6 Stage T1C
Robotic Surgery Sept 18, 2008
Pathology October 1, 2008 - Gleason 7 (3+4) Staged pT2c NO MX - Gland 50 cc
Seminal Vesicles and Lymph Nodes clear
Positive Margins Right Posterior Lobe
PSA 5 week Oct 2008 <.05
                   3 month Jan 2009     .06
                   6 month Apr 2009     .06
                   9 month Jul  2009     .08
                 12 month Oct 2009     .09 
                 18 month April 2010   .19


Ed C. (Old67)
Veteran Member


Date Joined Jan 2009
Total Posts : 2458
   Posted 4/9/2010 12:58 PM (GMT -6)   
Les,
Sorry about your latest PSA up tick. I wish you well going forward.
Age: 67 at Dx on 12/30/08
PSA 9/05 1.15; 8/06 1.45; 12/07 2.41; 8/08 3.9; 11/08 3.5 free PSA 11%
2 cores out of 12 were positive Gleason (4+4) and (4+5)
Negative CT scan and bone scan done on 1/16
Robotic surgery performed 2/9/09 Dr Fagin, Austin TX
Pathology report:
Prostate weighed 57 grams size:5.2 x 5.0 x 4.9 cm
Posterior lateral lesions measuring 1.5 x 1.4 x 1.0 cm showing focal capsular penetration over a distance of 3mm in circumference.
Prostatic adenocarciroma accounts for approx. 10-20% of the hemisphere.
Gleason 4+4
both nerve bundles removed,
pT3a Nx Mx, Negative margins
seminal vesicles clean, lymph nodes: not dissected
continent after 4 months
8 weeks PSA test 4/7/09 result <0.1
5 months PSA test 7/9/09 result <0.1
8 months PSA test 10/9/09 result <0.1
11.5 months test 1/21/10 result 0.004


BB_Fan
Veteran Member


Date Joined Jan 2010
Total Posts : 1011
   Posted 4/9/2010 1:15 PM (GMT -6)   
Les, Very sorry to hear about your rising PSA, but it looks as though you'll have a good chance for a cure with radiation. I'm in the same boat as you are. My PSA just went up much more than I expected.
Dx with PC Dec 2008 at 56, PSA 3.4, Biopsy: T1c, Geason 7 (3+4)

Robotic Surgery March 2009 Hartford Hospital, Dr Wagner
Pathology Report: T2c, Geason 8, organ confined, negitive margins, lymph nodes negitive
nerves spared, no negitive side effects of surgery

One night in hospital, back to work in 3 weeks

psa Junl 09 <.01
psa Oct 09 <.01
psa Jan 10 .07 re-test one week later .05
psa Mar 10 .28 re-test two weeks later .31


Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4106
   Posted 4/9/2010 2:07 PM (GMT -6)   
Darn Darn Darn!!!!! so sorry Les. Seems quite a few had had to go the RT mopup. Good luck my friend.

Cajun Jeff
9/08 PSA 5.4 referred to Urologist
9/08 Biopsy: GS 3+4=7 1 positive core in 12 1 pre cancer core
10/08 Nerve-Sparing open radical
Surgery Path Report Downgrade 3+3=6 GS Stage pT2c margins clear

3 month: PSA <0.1
6 month: PSA <0.1
10 month:PSA <0.1
1 year: PSA <0.1
16 month:PSA <0.1

ED - Started Cialis at 3 months, tried all 3, 6 months added pump, 9 months Tried MUSE (YUCK) Bad experience.
1 year mark Found new Urologist visit was at 14th month post surgery
Started Injections, Caverject! (Success)
17 month: ED making improvements : Oral Meds gets me 85%


LV-TX
Veteran Member


Date Joined Jul 2008
Total Posts : 966
   Posted 4/9/2010 4:04 PM (GMT -6)   
Thanks Ed BB_Fan and Jeff. I am going to hate going home to tell the wife though tonight....she is the pessimist in the family and I am the eternal optimist. Personally, it's just those trials in life we all face in different degrees. I have to spend the weekend and keep the wife occupied to get this dang stuff off her mind for awhile.

BTW...BB_Fan...Baseball season....Rangers win opener
You are beating back cancer, so hold your head up with dignity
 
Les
 
Age 58 at Diagnosis
Oct 2006 - PSA 2.6 - DRE Normal
May 2008 - PSA 4.6 - DRE Normal / TRUS normal
July 2008 - Biopsy 4 of 12 Positive 5 - 30% Involved Bilateral w/PNI - Gleason (3+3)6 Stage T1C
Robotic Surgery Sept 18, 2008
Pathology October 1, 2008 - Gleason 7 (3+4) Staged pT2c NO MX - Gland 50 cc
Seminal Vesicles and Lymph Nodes clear
Positive Margins Right Posterior Lobe
PSA 5 week Oct 2008 <.05
                   3 month Jan 2009     .06
                   6 month Apr 2009     .06
                   9 month Jul  2009     .08
                 12 month Oct 2009     .09 
                 18 month April 2010   .19


deer hunter
Regular Member


Date Joined Jan 2010
Total Posts : 246
   Posted 4/9/2010 4:25 PM (GMT -6)   
Sorry to here that news Les but i think some rad should get the rest of it
Best of luck !!!!!!!!!!!!
DEERHUNTER
dx age 57 01/06 open RP 4/06 psa in 01/06 8.1  surgery path report Gleason 3+4=7 poorly differentiated  tumor was 90%involved in both lobes surgical margins postive. in the right apex and right radial margins tumor grade G3  perineural invasion present high grade of PIN found  T2c NX MX PSA 0706  .01 10/06 .02 01/07 .03 04/07 .04  06/07 .05  07/07 .08 07/07 bone scans pelvic ct neg. 08/07 proscintic scan neg.9/07 psa.10 net with rad onc. wanted to do SRT but i did not do it 10/07  saw a new dr at Emory University [my old dr urg. suggested second opinion ]  bone scans negs ct scans pelvics neg. biopies of the bladder and adrinal glands neg.another proscintic scan neg.12/07 Psa .11 clinial trial Emory injected with protons to try and find the cancer cells no luck 3/08 psa .17 06/08 psa .23 psa 09/08 psa .32 12/08 psa .39 3/09 psa .39 6/09 psa .43  meet with medical onc. he said  i might have waited to long to start SRT 7/09 psa .50  another bone scan ct scan all neg.MRI neg. meet rad. psa the last of 7/09was .55 onc. 7/09 started casdex 50mg 1 day for 30 days 2 shots of lupron started rad treament 10/09 40 treatments 75 gm 12 shots each time all aroud pelvic finished 12/09  psa .07 and psa 01/10.05 next dr visit 03/10 wait and see 3/10 psa.05


DS Can
Regular Member


Date Joined May 2009
Total Posts : 195
   Posted 4/9/2010 9:45 PM (GMT -6)   

Les,

Keep the good attitude.  Support those around you when they need it.  I forwarded my 1 year results to my wife today and she confided that she had been more worried about this one than the others.  I guess she hasn't forgotten that I had/have cancer.  I look forward to hearing good updates from you.

And yes, "You are beating back cancer, so hold your head up with dignity", says it very well.

Dan


PSA 01/07: 1.2,  01/08: 1.9,  01/09: 2.5
BIOPSY 02/24/09  PCa DX, age 52
Right: 3+3=6, 3/6 cores 10% involved,PNI-Y
Left:  3+3=6, 1/7 cores <5% involved,PNI-N
LARP 04/09/09 nerve sparing. Final pathology:
GS 3+4=7, Margins uninvolved, 2 lymph nodes negative
Catheter out 04/17,1st no-pad day 05/03 
PSA: 04/08/10 <0.1
 
 


Swimom
Veteran Member


Date Joined Apr 2006
Total Posts : 1732
   Posted 4/9/2010 10:29 PM (GMT -6)   
We're holding your place! Memberships here are good forever. God Speed Les

Swim
 Hilarem datorum diligit Deus


Sephie
Veteran Member


Date Joined Jun 2008
Total Posts : 1804
   Posted 4/10/2010 5:24 AM (GMT -6)   
Les, don't worry ... we'll hold your bar stool for ya!

We are sorry to hear the news about your PSA - a real bummer. Interesting that your PSA rose about the same amount of time after surgery as my husband's - hopefully yours will go back down as well! Wonder if there is something like a PSA "bump" after surgery (like there is after primary radiation therapy) due to benign prostate tissue left behind.
Husband diagnosed in 2/2008 at age 57 with stage T1c. Robotic surgery performed 3/2008. Stage upgraded to T3a (solitary focus of extraprostatic extension). Perineural tumor infiltration present. Apex margin, bladder neck and SVs negative. Final Gleason 3+4. PSA: 0.0 til July 2009. August 2009 - 0.1, September 0.3, October back to 0.0, December 0.0, March 2010 0.0. Next PSA in 6 months. Thank you God!


Bootheel
Regular Member


Date Joined Oct 2007
Total Posts : 300
   Posted 4/10/2010 8:16 AM (GMT -6)   

Hang in there Les.

I had a positive margin at surgery.  My PSA rose to .18 about 18 months out.  Had 37 IMRT treatments.  Six months later my PSA was 0.00.  Things will work out.  Getting radiation at this stage of the game will provide the best positive outcome.


Age 65
Diagnosed 10/12/07
PSA 6.3
Biopsy 18 core samples, 2 positive <5%
Stage T1a Gleason 6 (3+3)
LRP  1/29/08
Post-op
Gleason 7 (3+4)
1 positive margin (.3cm)
T2C
4/16/08- Started Bi-mix injections 
5/15/08- 1st Post-Op PSA 0.07 Undetectable
8/11/08 -2nd Post-OP PSA 0.02 Undetectable
8/15/08- No more pads as of today  Whoopee!!!
11/13/08- 3rd post-op PSA 0.02 Undetectable
03/02/09- 1 yr. post-op PSA .09 Undetectable
05/13/09   PSA .18 (ouch)
Started IMRT June 13, 2009
Completed 37 treatments July 31, 2009 (66.6gy)
11/23/09 Post IMRT PSA .18
2/12/10   Post IMRT PSA 0.00

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