Continue Zoladex/Leucrin despite being "refractory"?

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New Member

Date Joined Mar 2010
Total Posts : 7
   Posted 4/11/2010 6:24 PM (GMT -6)   
I was on intermittent Zoladex/Leucrin injection for 6 years before becoming hormone refractory.
But the doctors still want me to take the injection every 3 months, claiming that even though I'm officially refractory, the injection will still suppress a 'certain population' of PC cells.
Needless to say that when I was on intermittent therapy I felt better without the Zoladex/Leucrin side effects.
The question is: is it really still worth getting the injection? 

Regular Member

Date Joined Apr 2010
Total Posts : 54
   Posted 4/15/2010 12:22 PM (GMT -6)   
There is very good information available on:

Look for A Patient's Guide to Managing Hormone-Refractory Prostate Cancer

It says that you should stay on Zoladex/Lupron (Leucrin) because it will continue to suppress the testosterone that would otherwise stimulate the cancer cells to profilerate.
Diagnosed at age 63 Sep'09: PSA 575, GS 7 (4+3)
3 positive cores in 6
Bone scan: as a fully lit christmas tree
With Zoladex+150mg Casodex PSA <0.1
Additionally 4-weekly Zometa (zoledronin acid)

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 4/15/2010 2:36 PM (GMT -6)   
Panascope- you might want to consult the top flight onco docs-like: Strum, Scholz, Meyers, Vogelzang and their peers and such. They have treated about every scenario presentation of PCa and know alot about the tricks of switching of drugs to control PCa...knowing what I know and have done and witnessed over these many could likely do better with specialist PCa onco-doc types. Alot of docs may put you on this stuff for life....but did they mention you have many other choices, did they mention alot of various drug protocols, some are more expensive and some are super cheap and others in between? Do you ever wonder why they are not mentioned? There are some drugs that work better against  HRPCa that you are dealing with and can cause direct apoptosis on many guess is you were never informed of such. Question everything with PCa and seek further opinions for comparisons to enlighten yourself on what is out there and your choices.

Youth is wasted on the Young-(W.C. Fields)

Post Edited (zufus) : 4/15/2010 1:40:49 PM (GMT-6)

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