SUCCESS WITH FROZEN TRIMIX

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geon
Regular Member


Date Joined Oct 2007
Total Posts : 103
   Posted 4/16/2010 6:34 PM (GMT -7)   

SUCCESS WITH FROZEN TRIMIX!

I am 38 months out from DaVinci RP and have been using Trimix since month 8.  I wanted to share with you some factual news regarding frozen Trimix that I can personally attest to.

 

about July 1, 2008 I purchased a new mix from a local specialty pharmacy in the St. Louis area.  When I arrived to pick the prescription, the pharmacist made me aware he had reduced the price to $50 for a 10cc bottle because the material was within two week of “expiration”.  In addition, knowing that he most probably would not be able to sell some of the remaining mix by this expiration date he asked if I would be interested in taking another 10cc bottle with the mix frozen.  For free? Why not and $50 for 20cc if it all worked out.  Having freezer packs with me in a cooler I headed home with a smile.

 

The first bottle lasted me from that date of purchase until the last drop was used on March 31, 2010.  Mind you that the dosage gradually had to be increased as time went on with 0.10cc being the max.  For 20 months the 10cc bottle did well with solid performance.  It was time for the frozen Trimix and I was excited to see what the results were going to be.  I started the first injection with 0.06cc.  It worked with excellence but a little heavy on the dosage amount.  Very firm for over four hours but somewhat pleasant.  More annoying then anything else and it faded slowly with no alarm or Sudafed.  I have been there before on overdose and I new I was not in that situation so all went OK.  After a few more injections I am down to 0.03cc with very firm erections.  I will reduce this amount to check on the results but I believe I am on the edge.  I think it will be OK but will require more stimulation.

 

I presume I have about 20 months on the 10cc bottle also.  All in all, this is probably the best bargain that I will ever come across for Trimix.  Moral of the factual story is two fold, don’t let the expiration date fool you and don’t be afraid to use good frozen Trimix!

 

Hope this was helpful,

Marc


66 years old 01252010; healthy; active,
married 43 years, good strong erections before surgery.
DaVinci Prostate Removal February 5, 2007
2/12 samples malignant.
Catheter removal 2/13.
Viagra 25mg every other day from 2/14 to 5/12. no help.
Incontinence almost gone after three months.
No pads, occasional  dribble.
Lavitra every other day 5/12 to 7/22. no help.
Muse 1000mcg - no help (50% at best). little help.
Cialis twice a week 7/25/07 to 11/6/08. no help.
Vacuum pump - Huge erections but not useable.
Trimix injections started.  0.09cc is great! 10/08/07.  Still good at 0.10CC and stimulation.
First drug induced erection 10/8/07....Wow!
Natural erections - 0 as of 2/5/07.
PSA's, many to date undetectable.  Thank God!
Total ED...Since 2/5/07  URO took me off oral drugs 11/2008.
Geon


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25343
   Posted 4/16/2010 6:59 PM (GMT -7)   
Marc,

I think that is amazing that it works after being frozen for so long. Congrats on an interesting test.

David in SC
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14 out - 27 days, Cath #15 - 3/29


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4795
   Posted 4/17/2010 3:36 AM (GMT -7)   
Guess you're still real excited about this.....(you already posted about it) smhair http://www.healingwell.com/community/default.aspx?f=35&m=1765310
Age 55   - 5'11"   215lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4461
   Posted 4/17/2010 7:52 AM (GMT -7)   
Is the frozen Trimix drawn into seperate syringes for a per use dose, then frozen or is the entire vial frozen and thawed out at each use, for the thawed out liquid to be drawn into the syringe? I would have some concern about a long term effect of continued thawing and refreezing. Any ideas on this possible issue.
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 10 gms., margins clear
32 Months: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


geon
Regular Member


Date Joined Oct 2007
Total Posts : 103
   Posted 4/17/2010 7:59 PM (GMT -7)   
Steve n Dallas,
Yes, I did post earlier as you stated and thank you for being observant. I had not received any replies and thought it would be worthy to report this news onec again but in a different written approach to see if I could make the presentation mor appealing and noticeable.  Looks like the second time worked much better as I did receive at least some attention.  And YES, I am still real excited about helping others by passing on REAL factual data.
 
James C.
The mix was obtained in a 10cc bottle frozen solid from the pharmacist.  I transported the frozen mix in a cooler filled with ice packs to my home freezer immediately and it remained in the freezer for 20 months.  When I thawed the frozen mix the first time it then remained in the refrigerator as it  is today.  My syringes are filled on demand when needed from the unfrozed material.  I do not freeze/un freeze.  This, as in food products, is NOTa good idea.
 
I suppose if you filled several syringes from a never frozen mix and then froze them to be used one at a time then you would be OK.
Marc
66 years old 01252010; healthy; active,
married 43 years, good strong erections before surgery.
DaVinci Prostate Removal February 5, 2007
2/12 samples malignant.
Catheter removal 2/13.
Viagra 25mg every other day from 2/14 to 5/12. no help.
Incontinence almost gone after three months.
No pads, occasional  dribble.
Lavitra every other day 5/12 to 7/22. no help.
Muse 1000mcg - no help (50% at best). little help.
Cialis twice a week 7/25/07 to 11/6/08. no help.
Vacuum pump - Huge erections but not useable.
Trimix injections started.  0.09cc is great! 10/08/07.  Still good at 0.10CC and stimulation.
First drug induced erection 10/8/07....Wow!
Natural erections - 0 as of 2/5/07.
PSA's, many to date undetectable.  Thank God!
Total ED...Since 2/5/07  URO took me off oral drugs 11/2008.
Geon


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4461
   Posted 4/18/2010 6:08 AM (GMT -7)   
Marc, thanks for clarifying that. I know there's been guys here in the past who had really dialed in their dose that would draw out their individual dose and freeze the syringes, removing one as needed to thaw and use. I can say that I have used refrigerated bimix up to a year after the official expiration date with no changes in appearance and no ill effects from it. As you say, a little more needs to be used as you go along, but that is to be expected. I have trimix and bimix that are approaching their date in a couple months, so I will try you technique, but by freezing the individual syringes and see how that goes.
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 10 gms., margins clear
32 Months: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


green envy
New Member


Date Joined May 2010
Total Posts : 1
   Posted 5/12/2010 8:27 AM (GMT -7)   
New to this site. I see that some recommend freezing Trimix.
Checked with company and they are highly against the idea.
They state that the med has a shelf life of 4 months when
refrigerated. They argue against freezin the med in the syringe
due to sterility issues as well as the possibility of the syringe
becoming weak and breaking either in freezer or during
injection (ugh).
 

Gleason7
Regular Member


Date Joined Feb 2010
Total Posts : 111
   Posted 5/12/2010 9:14 AM (GMT -7)   
Seems like personal experience is more reliable then the manufacturers sine they are in the business to produce and sell the stuff right?

Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4795
   Posted 5/12/2010 10:43 AM (GMT -7)   
On the other hand - one would think they know more about it then we do...or at least more then I do.
 
A pair of tweezers should be able to grab that broken needle pretty easily...Getting up to get the tweezers might not be fun.
 
Considering the location of the injection site - I'll error on the side of caution thank you very much yeah

Gleason7
Regular Member


Date Joined Feb 2010
Total Posts : 111
   Posted 5/12/2010 1:34 PM (GMT -7)   
Frozen meds are one thing but a broken needle's a whole other matter.

jackv10
New Member


Date Joined Dec 2014
Total Posts : 1
   Posted 12/27/2014 2:55 AM (GMT -7)   
I am not sure what type of needle youare using but mine are all plastic ,So I cannot see them breaking if frozen

GotHemi?
New Member


Date Joined Jan 2015
Total Posts : 3
   Posted 1/18/2015 11:52 PM (GMT -7)   
Upon receiving my first trimix vial (which has a exp date that comes too quickly) my urologist informed me to, ASAP, preflll all my syringes with the required dose. Then freeze. Remove from freezer as needed, thaw for about 15 minutes by using the warmth of you hand & the heat of your breath. (Works for me). Then inject & have at it......😀

jay1957
Regular Member


Date Joined Dec 2014
Total Posts : 134
   Posted 1/19/2015 4:57 AM (GMT -7)   
I have been using Trimix since November and it works well. My dosage comes frozen and can be kept frozen for 6 months or so. I get two small bottles. One is to go in the refrigerator and can last 4 to 6 weeks. So far I have not had any problems with either (frozen or in the fridge). Been working well to this point.
PSA - 5.9 3/14
Biopsy - 5/14 - 3 of 12 had 3+4 Gleason
DaVinci surgery - 8/14; Gleason score was 3/3; contained in prostate
PSA score of 0.0 10/14

PeterDisAbelard.
Forum Moderator


Date Joined Jul 2012
Total Posts : 5640
   Posted 1/19/2015 8:18 AM (GMT -7)   
If you freeze prefilled syringes don't forget that water expands 9 percent when it freezes. Because the plastic cap and the air-gap protects it from the cold the needle tends to freeze last and, as the contents of the cylinder freeze, the trimix tends to dribble out the needle. If you don't want to lose a bit you should leave a several-unit bubble in the syringe and freeze them needle-up.

I figured all this out when I noticed that 35 units of frozen trimix turned into 32 units when re-thawed.
61
Slow PSA rise 2007-2012: 1.4=>8
4 bxs 2010-2012:
1)neg
2)neg,
3)positive 1 of 14 GS6(3+3) 3-4%, 2nd opinion GS7(3+4)
4)neg.
Mild Pre-op ED
DaVinci RRP 6/14/12. left nerve spared
Path: pT3a pN0 R1 GS9(4+5) Pos margins on rt
24 mo ADT3 7/12 - 7/14
Adjuvant IMRT 66.6 Gy 10/17/12 - 12/13/12
Incontinent, Trimix, VED, (AUS Planned)
Forum Moderator - Not a Medical Professional
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