Interesting Study on HT side effects by Johns Hopkins

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Sonny3
Veteran Member


Date Joined Aug 2009
Total Posts : 2448
   Posted 4/22/2010 1:21 PM (GMT -6)   
As one who recently had conversations with my Medical Oncologist about HT, I found this study very interesting.

It details a few things other than the normal side effects that have been discussed here more often. Thought I might post it here for others to see and chime in on.

http://www.johnshopkinshealthalerts.com/alerts/prostate_disorders/JohnsHopkinsProstateDisordersHealthalert_3400-1.html?ET=johnshopkins_blog:e37363:548695a:&st=email&st=email&s=EPH_100422_005

Sonny confused
60 years old when diagnosed
PSA 11/07 3.0
PSA 5/09 6.4
Diagnosis confirmed July 9, 2009
12 Needle Biopsy = 9 clear , 3 postive
Gleason Score (3+4) 7 in all positive cores
da Vinci 9/17/09
Post Surgery Pathology: GS 4+3=7
Stage: T3a
Tumor Volume 12.5%
positive margin, extra-prostatic extension
30 day PSA 0.4, 50 day psa 0.53, 64 day psa 0.6
IMRT completed 1/15/10 35 treatments- 70Gy

2/24/10 FIRST POST RAD PSA 1.0---CARRRP --waiting for the next test.
3/22/10 Second Post RAD PSA 1.5 Dammmmnnn stubborn son of a gun
4/19/10 YAHOO PSA dropped to 1.2 Moving in the right direction.


compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7269
   Posted 4/22/2010 5:48 PM (GMT -6)   

Bad link--says page is unavailable

 

Mel


63 years old . PSA-- 3/08--2.90; 8/09--4.01; 11/09--4.19 (Free PSA 24%),  after 45 days on cipro! DREs have always been normal. PCA-3 was about 75 (way above the 35 threshold). That led to:

Biopsy on 11/30/09. 5 out of 12 cores positive. Gleason 4+3. 2 cores were 3+3 (one 5% and the other 30%) on one side. On  other side:2 cores are 4+3 (5%)--1 core 3+4 (30%) no peri-neural invasion. prostate is 45 grams. Stage: T1C.  

Surgery with Dr. Menon at Ford Hospital, 1/26/10. He says all looked good. Spared nerves. Unfortunately: Pathology Report: G 4+3 (65%-35%). Cancer in 15% of gland. Lymph Nodes: Clear.  Perineural Invasion: yes. Seminal Vessical Involvement: No.  Extraprostatic Extension: yes.  Positive Margin: Yes-- focal-- 1 spot .5mm. Final Weight is 52.7 gms.  (Second opinion from Jon Epstein at Hopkins confirmed these results)

 Incontinence: joined that club-- definite leaks—1 pad/day. Night is dry, was  using 1 pad at night for security, but pretty much dispensed with that most nights. Update: no pads at night. No pads while at home, but still very uncomfortable. Use 1 pad for out-of-house activities. Suddenly got MUCH better on 3/10/10, almost overnight. Still some urgency but no pads about 90% of the time.  As of 3/12/10--completely continent! Uh...OH. As of about 3/16/10 problems with constant urgency although no pads needed--feels like an infection but none showing in urine.

First post-op PSA on 3/10/10--DRUM ROLL: 0.01 Next PSA in mid-June.


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 4/22/2010 6:46 PM (GMT -6)   
Sonny, I couldnt get the link to work either, perhaps you can recheck it?
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14 out - 27 days, Cath #15 - 3/29


Sonny3
Veteran Member


Date Joined Aug 2009
Total Posts : 2448
   Posted 4/22/2010 10:12 PM (GMT -6)   
I think the link worked for me because I am signed up for JH alerts on Prostate issues on a weekly basis. I'll research and see if I can get the link to work for others. It is really worth reading. Talks about more than hot flashes and the emotional side of HT.

Sonny
60 years old when diagnosed
PSA 11/07 3.0
PSA 5/09 6.4
Diagnosis confirmed July 9, 2009
12 Needle Biopsy = 9 clear , 3 postive
Gleason Score (3+4) 7 in all positive cores
da Vinci 9/17/09
Post Surgery Pathology: GS 4+3=7
Stage: T3a
Tumor Volume 12.5%
positive margin, extra-prostatic extension
30 day PSA 0.4, 50 day psa 0.53, 64 day psa 0.6
IMRT completed 1/15/10 35 treatments- 70Gy

2/24/10 FIRST POST RAD PSA 1.0---CARRRP --waiting for the next test.
3/22/10 Second Post RAD PSA 1.5 Dammmmnnn stubborn son of a gun
4/19/10 YAHOO PSA dropped to 1.2 Moving in the right direction.


Sonny3
Veteran Member


Date Joined Aug 2009
Total Posts : 2448
   Posted 4/22/2010 10:18 PM (GMT -6)   
I know we don't like cut and paste, but since it is a fairly short article, I hope the modes won't mind. I can't seem to make the link work for others.

Here is the news brief that was emailed to me:

Male sex hormones (androgens) -- testosterone in particular -- are required to maintain the size and function of the prostate. As a result, a number of prostate cancer treatments are aimed at interfering with the effects of androgens. Blocking testosterone can temporarily cause the cancer to regress, or at least to grow more slowly.

Now research reported in BJU International (volume 102, page 44) finds that men who undergo androgen-deprivation therapy (ADT) for prostate cancer lose bone and muscle mass and accumulate more body fat.

Researchers documented these changes in body composition over 36 weeks among 72 men (median age, 73) with prostate cancer who were receiving intermittent ADT. At the start and end of the study, the men with prostate cancer underwent dual-energy x-ray absorptiometry scanning to determine whole-body and regional lean mass, fat mass, and bone mineral content and density. The researchers also measured PSA, testosterone, and hemoglobin levels and evaluated the men's physical activity levels and fatigue at both time points.

Bone mineral density decreased by about 1.5% at the hip, 4% at the spine, 2% for whole body, and 1% in the upper limbs. Lean body mass decreased in the upper limbs by about 6%, in the lower limbs by 4%, the trunk by 1%, and whole body by 2%. During the same period, fat mass at these sites increased by 21%, 19%, 12%, and 14%, respectively. The men also experienced greater levels of fatigue and became less active during the treatment period.

Bottom line: If you're on ADT for your prostate cancer, be aware that over time, these changes can increase the risk of cardiovascular disease, bone fractures, and falls. Taking steps to reduce your risk of these conditions, including lifestyle changes and medication, is an important component of your care.

Sonny
60 years old when diagnosed
PSA 11/07 3.0
PSA 5/09 6.4
Diagnosis confirmed July 9, 2009
12 Needle Biopsy = 9 clear , 3 postive
Gleason Score (3+4) 7 in all positive cores
da Vinci 9/17/09
Post Surgery Pathology: GS 4+3=7
Stage: T3a
Tumor Volume 12.5%
positive margin, extra-prostatic extension
30 day PSA 0.4, 50 day psa 0.53, 64 day psa 0.6
IMRT completed 1/15/10 35 treatments- 70Gy

2/24/10 FIRST POST RAD PSA 1.0---CARRRP --waiting for the next test.
3/22/10 Second Post RAD PSA 1.5 Dammmmnnn stubborn son of a gun
4/19/10 YAHOO PSA dropped to 1.2 Moving in the right direction.


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4268
   Posted 4/23/2010 11:07 AM (GMT -6)   
These side affects have been documented for years:
Before going on HT get an echo stress test and a bone density test. These are used as baselines for cardiac and bone loss.
Weight training is a must or you will lose both bone and muscle mass. As long as you are training regularly you can hold the muscle loss to zero.
JT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.

JohnT


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 4/23/2010 12:40 PM (GMT -6)   
Those minor side effects (LOL) are not the same and alot is just the opposite mostly on what happens when using: DES, emcyt, estradiol patches(vs. the LHRH's as per your info)...which some patients would be better candidates for and some might not if one is of high blood clotting risk parameters. Of course most all the docs literally push LHRH (Lupron, Zoladex, Eligard, Precisis, Trelstar) and or casodex and its equals, and they work but have alot of effects and costs in many ways and highly profittable. Long term useage is possibly a real serious dilemna but it is hopefully a patients choice, as there are still many other drugs to fight PCa, many more.

The estrogen drugs I mentioned, in Journal of Urology article Nov. 2003- builds or does not deplete bone density (+++), doesn't deplete memory as does the (LHRH)other things, I can atest to looking, feeling and being stronger on these alternative drugs, of which there is no profits to be made. Did ADT3 for 2 yrs.(glad that ended), done DES intermittently for around 4 yrs., huge difference in effects, for me had way better psa results, extremely low in costs (mega difference in cost). Journal article mentions 1 -mg as being a safe doseage, 5-mg used 30-50 yrs. ago was not always safe but was highly effective and was used for many decades and still used today in many countries, too. But of course your uro-doc (genius) will tell you it is junk or that patches are too,(based upon???), however wiser onco-docs may or will prescribe it to you as some do for patients. Is treating patients all about the money???? Well you can contemplate what the experts are doing by their acts and history and decided for yourself, perhaps.
Youth is wasted on the Young-(W.C. Fields)


JoeyG
Regular Member


Date Joined Jul 2009
Total Posts : 162
   Posted 4/23/2010 3:12 PM (GMT -6)   
Zufus and I definetly agree on this; however Zufus has actually taken both types of drugs and I will soon be in the process. I would LOVE to take part in a clinical trial for estrogen (as long as the "placebo" was Lupron or Zolodex). However, I am not aware of any trials for this. Therefore, in my quest to find an onco, I need to find one with an open mind.

Age -57; Diagnosed 10/05 PSA 13.4 GS 7 (4+3) Organ confined (T2B)
Cryoablation 4/06 Allegheny Hosp-Dr Ralph Miller (Cohen/Miller)
Post Cryo Nadir 8/06 0.2
Rising steadily to 0.7 4/09 :-(
Steady at 0.7 (7/09)
Doubled to 1.5 (2/10) YUCH!
Hoping to qualify for salvage cryo or radiation


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 4/23/2010 3:17 PM (GMT -6)   
This is an honest question looking for an honest answer, but hopefully an answer thats more than about the "money" aspect:

Why are most of the doctor's I have talked to locally, been either out right negative to HT, or real cold at best. I am talking about my Uro, Surgeon, 2 of 3 radiation oncologist, my original medical oncologist from 10 years back, and even my GP of 13 years plus.

Besides the obvious more visible side effect issues, i.e. gaining weight, hot flashes, etc, could it be because of more serious long term issues like Sonny's clip indicated? I know that it has helped several of you guys in particular, and I am one that never wants to argue with success.

The doctors I have talked to seem to be up to date on technology and breakthroughs in general. Just trying to figure out their collective coolness with HT in general.

This is kind of a part 2, meant to include also, when HT drops the PSA, in some case dramatically, is it just masking what is really going on, or is it really lowering the PSA to the new lower levels? If it is masking, then is that a good or bad thing other than buying time for the patient?

David in SC
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 4/23 put in


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 4/23/2010 3:54 PM (GMT -6)   
ohio, thanks for the answer. my question is not so much about me, in fact, very little at this point, just trying to understand again, why I have received coolness at best on the subjct of HT at the professional level. Again, not arguing with what happens to work for you, or any one else in particular. Trying to understand from the doctor's mind set.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 4/23 put in


Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 4/23/2010 4:16 PM (GMT -6)   
Sonny, thanks for posting the info.  David,  Dr. Myers has an article on the PCRI web site,  www.prostate-cancer.org/pcricms/node/203  that may answer your questions.  Here is a short paragraph from his article titled, "Beating Prostate Cancer with Hormonal Therapy".
 
"Over the last several years, a growing number of patients tell me they’ve been told that hormonal therapy doesn’t kill prostate cancer cells, but just stops cancer growth and artificially lowers the PSA test, thereby fooling us into thinking cancer cells have actually died. I find this myth very strange. Time and again, hormonal therapy clinical trials have reported shrinkage of measurable cancer metastases. Depending on the clinical trial, up to 30% of patients enter complete remission, which means that all detectable prostate cancer has disappeared! How can you enter a complete remission without having killed prostate cancer cells?"
 
I hope this helps.
 
Carlos

Diagnosed 2/2008 at age 71, Gleason score 5+3=8, stage T1c, PSA 9.1. 
Robotic surgery 5/2008, nerves spared, All margins, SV and lymph nodes negative. 
Staged pT2c, Gleason score 5+3=8.  PSA <0.1 at 20 months, Jan. 4, 2010.


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 4/23/2010 4:22 PM (GMT -6)   
carlos, that is a very interesting clip towards my questions. That would indicate to me that its not just masking, but it has some real power behind the delievery of the HT drugs. Thanks as well.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 4/23 put in


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4268
   Posted 4/23/2010 4:40 PM (GMT -6)   
David,
PC cells are either androgen dependent or androgen independent. Most tumors have both cells. HT will kill the androgen dependent cells, and if that's all you have then you will go into complete remission. A lot of patients have a small number of androgen independent cell which keep on growing. Hence the intital reduction of psa due to androgen dependent cells dying then a future rise as the androgen independent cells keep growing.
This is the simplified version as there are many variations to this.
This is also why HT works well on some patients and on others it works for only a short period of time. A good oncologist can mix things up and through other tests can find out what works and what doesn't. It is critical to get a oncologist skilled in PC as PC works differently than other cancers and there are a lot of tricks a good doc has to keep you living a long time.
JT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.

JohnT


dkob131
Regular Member


Date Joined Apr 2008
Total Posts : 364
   Posted 4/23/2010 5:02 PM (GMT -6)   
David:  In my opinion and most others Dr. Meyers and Dr. Strum are considered two of the leading specialists when it comes to prostate cancer and both of them consider HT to kill cancer cells.  If you are really interested I would suggest you get Dr. Meyers book, google to get the titile because I don't have it in front of me right now.  All of the larger, cutting edge hospitals to include M.D. Anderson, Univ. of Washington, John Hopkins follow the HT protocol to some extent, ADT 3 has become the gold standard for these institutions.  Dr. Meyers, in the book addresses the myth as he calls it that HT doesn't kill prostate cancer cells.  I'm not crazy about being on the therapy, I'm over 9 months into it and the Docs. want me to complete 2 years which I will do because I believe that it gives me the best chance of cure.
 
The other David
  
 54 y.o.
 Diagnosed 4/10/08
 DRE Normal
 PSA-5.5
 Biopsy- 12 cores, 4 positive highest 4+4=8
 Bone scan, CT scan and Chest X-ray clear 4/16/08
 Urologist suggested surgery 4/16/08
 MRI on 4/24/08 clear no suggestion of lymph node   involvement.
 4/24/08 -Started on Lupron and Casodex preparing for HDRT and IMRT in late July.  This treatment will not preclude me from surgery if I change my mind.
Decide to have DaVinci surgery after another consult with surgeon.
6/19/08- DaVinci surgery at University of Washington.
6/25/08- Path report, clear margins, no noted extension
9/12/08- PSA <0.02 
12/05/08-PSA <0.02 Six months after surgery 
3/02/09-PSA <0.02 Nine months after surgery
5/02/09-PSA .10
8/17/09-PSA .21 Begin HT and set up for SRT to begin in 2 months.
 


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 4/23/2010 5:42 PM (GMT -6)   
Ohio: that's exactly why I am trying to find the right way to ask these kinds of questions, of all things PC, I am a complete novice with HT methodology and matters dealing to advanced cases. I think many of us here need to learn more about that end of things.

John: your answer and point of view already helped to explain something on this subject for me. Still sounds very complicated.

David, sounds like you are well informed, and on the right path for you at this point in your journey. Sounds like it would really take a seriously dedicated to the subject of HT kind of doctor to know what he/she was doing with their patients at that juncture. Lot of complicated drugs, with complicated dosing and use.

Surgery is a little more straight forward, as far as understanding, there's a real physical and mechanical feel to it. And having been through major radiation twice in my life so far, I understand the basic "mechanics" of that as a treatment. But the HT stuff and research and clinical testing is way over my head, and I am the first to admit that.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 4/23 put in

New Topic Post Reply Printable Version
Forum Information
Currently it is Friday, September 21, 2018 1:22 PM (GMT -6)
There are a total of 3,005,478 posts in 329,227 threads.
View Active Threads


Who's Online
This forum has 161775 registered members. Please welcome our newest member, Rawle.
312 Guest(s), 7 Registered Member(s) are currently online.  Details
JoHnGaMeR90, cashlessclay, Girlie, FamilyGuy, InTheShop, jdiane, (Seashell)