Your psa is worrisom. There is a consistant rise over time and this indicates a probability of PC. Did you get a free PSA? You should also get a PCA3.
I went through the exact same situation for 10 years and had biopsies from 4 different doctors, a total of 12. The last biopsy in OCT-08 picked up 1 small core of G6 out of 24 samples. I guess I had over 150 samples over the 10 years. I went to a noted prostate oncologist for a 2nd opinion and he said that just by looking at my history he was certain that I had a significant cancer, not just the one core that was found, and sent me to Dr Bahn for a color doppler ultrasound. Dr Bahn found a large tumor G7 in the transition zone and explained that most urologists don't know how to sample the transition zone which contains 25% of all prostate cancers and that 12 more biopsies would have also missed it.
After 3 negative biopseis I would get a color doppler biopsy from Dr Duke Bahn, Fred lee or Doug Chin.
I only whished I had know about
this 10 years earlier.
Your psa has doubled in 2 years and that is not a good sign. The standard protocol after 3 negative biopsies is to over sample the anterior and this is best done by an expert in Color dopler ultrasound even if you have to travel to get one. It will be well worth the piece of mind. I have found that urologists are good at picking up and Dxing normal run of the mill PC tumors, but are totally lacking when it comes to anything out of the normal.
64 years old.
PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.
2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.
Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.
Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.
25 treatments of IMRT 6 weeks after seed implants. No side affects at all.
PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.