A link between Chondroitin Sulfate and PCa?

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Veteran Member

Date Joined Aug 2007
Total Posts : 1015
   Posted 5/3/2010 7:52 PM (GMT -6)   

Hi friends,

For many years, I have taken a combination of Glucosamine Sulfate and Chondroitin Sulfate to promote joint health and to decrease pain from arthritis. Recently, I became aware that there may be a connection between regular ingestion of Chondroitin Sulfate and prostate cancer. It appears to me that the evidence against Chondroitin Sulfate is inconclusive, but I offer the following links for your review:

Mayo Clinic: “Avoid [Chondroitin Sulfate] in individuals with prostate cancer”


Medical Journal: "chondroitin sulfate glycosaminoglycan predicts progression in early-stage prostate cancer"


Chondroitin Sulfate Supplement Promotion Web Site: "Do not use chondroitin sulfate if you have prostate cancer or an increased risk for prostate cancer"


University if Michigan Health System: "Simply because a substance is present in or around cancerous tissue does not by itself suggest that that substance is causing the cancer"


Even though the evidence is not fully conclusive, I have decided to avoid Chondroitin Sulfate, for now, as part of my health supplement regimen.

In all my searches, I found no link between ingestion of Glucosamine Sulfate and prostate cancer.

Happy reading!


Surgery: Da Vinci; July 31, 2007; 54 on surgery day;
Pathology: PSA: 4.3; Gleason: 3+3=6; T2a; Confined to Prostate;
Post RP PSAs: 09/'07 <0.04; 12/'07 <0.04; 03/'08 <0.04;
06/'08 <0.04; 12/'08 <0.04; 06/'09 =0.06; 09/'09 <0.04; 12/'09 =0.05;
Latest PSA 3/'10 <0.04

Elite Member

Date Joined Oct 2008
Total Posts : 25380
   Posted 5/3/2010 8:14 PM (GMT -6)   
Barry, from reading the links you supplied, that would have been good enough for me not to use it.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 4/23 put in

Veteran Member

Date Joined Jul 2009
Total Posts : 1267
   Posted 5/3/2010 8:20 PM (GMT -6)   
Interesting, Barry. Just so long as they don't find a link to ice cream, or amber rum, I'm going to be okay.

Sheldon AKA Sleepless
Age 67 in Apil '09 at news of 4 of 12 cores positive T2B and Gleason 3 + 3 and 5% to 25% PSA 1.5
Re-read of slides in June said Gleason 3 + 4 same four cores 5% to 15%
June 29 daVinci prostatectomy, Dr. Eric Estey, at Royal Alexandra Hospital Edmonton one night stay
From "knock out" to wake up in recovery less than two hours.  Actual surgery 70 minutes
Flew home to Winnipeg on July 3 after 5 nights in Ramada Inn  ---  perfect recovery spot!
Catheter out July 9
Final pathology is 3 + 4 Gleason 7, clear margins, clear nodes, T2C, sugeron says report is "excellent"
Oct 1st 09 -- dry at night, during day some stress issues.
Oct 31st padless 24/7 
First post op PSA Sept 09  less than 0.02
PSA on Oct 23 test again less than 0.02
PSA on Jan 8 less than 0.02
PSA on April 9 less than 0.02 

Veteran Member

Date Joined Aug 2007
Total Posts : 1015
   Posted 5/3/2010 8:33 PM (GMT -6)   
David, The warning from the Mayo Clinic impressed me a little.  I'd like to do some more research.
Sleepless, agree on the ice cream... especially rocky road!

Veteran Member

Date Joined Nov 2009
Total Posts : 1096
   Posted 5/4/2010 8:42 AM (GMT -6)   
I wonder if you might find refined fish oil or an NSAID would help with your joints and arthritis, without having adverse impact on prostate cancer (indeed, some of suggested beneficial impact). Of course, I am not a doctor, and so this is just an idea you could discuss with a doctor.
Age 46.  Father died of p ca. 
My psa starting age 40: 1.4, 1.3, 1.43, 1.74, 1.7, 1.5, 1.5

Veteran Member

Date Joined Sep 2009
Total Posts : 3172
   Posted 5/4/2010 12:56 PM (GMT -6)   
Barry, I've seen this reported before.

Do you know that you can also buy the Glucosamine alone? I used to take the combination and now take the Glucosamine, and I can't tell the difference in my problematic knee joint.

Forum Moderator

Date Joined Jan 2010
Total Posts : 6947
   Posted 5/4/2010 1:07 PM (GMT -6)   
I used the Glucosamine alone, then switched to the combo. Haven't been taking it for months, but I guess I can throw that bottle out now.

Regular Member

Date Joined Jan 2009
Total Posts : 189
   Posted 5/4/2010 1:39 PM (GMT -6)   

Hey Barry:

Very interesting- who knows what medications, foods and lifestyles might contribute to prostate cancer.

Years ago a group of us guys were having a beer at the local pub and chatting with a recent med school graduate who said current medical literature indicated that frequent mesturbation contributed to ongoing prostate health.

 One of the fellas wondered aloud whether this would still apply if he had someone else pull it for him.

63 years old-tumor discovered on digital exam- biopsy December 2008-
4 of 12 samples positive-all on right side
Gleason 3+3=6
Otherwise excellent health.
Brachytherapy- May 19, 2009 -so far, so good.
  "There may come a day when the courage of men will fail, but it will not be this day."

Regular Member

Date Joined Dec 2009
Total Posts : 345
   Posted 5/4/2010 4:52 PM (GMT -6)   
So deffo no link between PCa and glucosomine?
I was gonna get some this week...
Age 51
PSA 5.5  june 09
biopsy july 09 gleason 3+3 = 6   5% and 50% in 2 of 12 cores
robotic prostatectomy nov 7 prostate weight 45gm
path report due 8 jan 10
post op psa 22/12/09, 0.04
no incontinence after 7 days
total ed


Veteran Member

Date Joined Aug 2007
Total Posts : 1015
   Posted 5/4/2010 10:58 PM (GMT -6)   
medved: I think fish oil may have been helping my joints... I had been good about taking it daily last year and need to get back into it.

Casey: I want to try Glucosamine alone as well. Perhaps I'll take a trip to Costco tomorrow and see what they have in stock.

142: I have been considering throwing out my combo bottle as well. My wife reminded me last night that my family doctor told me years ago (before prostate cancer) that the jury was out on Chondroitin and my doctor believed that Glucosamine was the effective agreement.

mjluke: speechless

Mike: same here yeah

Thanks for all the responses, guys.
Surgery: Da Vinci; July 31, 2007; 54 on surgery day;
Pathology: PSA: 4.3; Gleason: 3+3=6; T2a; Confined to Prostate;
Post RP PSAs: 09/'07 <0.04; 12/'07 <0.04; 03/'08 <0.04;
06/'08 <0.04; 12/'08 <0.04; 06/'09 =0.06; 09/'09 <0.04; 12/'09 =0.05;
Latest PSA 3/'10 <0.04

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