Thanks reputo, I'm not sure if there are additional problems associate with sending slides to Germany. I did find that Bostwick does look for the following Biomarkers, I cut and paste from Bostwick website.
Biomarkers are used to determine the aggressiveness of cancer. A wealth of clinically useful information is available in even the smallest tissue specimens of the prostate, including biopsies and transurethral resections. Substantial effort has been expanded in the past decade in describing the available factors and determining their predictive value for staging, cancer recurrence and survival.
Proliferating Cell Nuclear Antigen (PCNA)
High PCNA labeling indices may indicate progression of prostate cancer,1,2 and may be an independent prognostic indicator.1
Ki-67 and MIB-1
Recognizes a nuclear antigen present in proliferating cells but absent in resting cells. Ki-67 labeling index may discriminate between organ confined and metastatic cancer.
Microvessel Density (MVD)
Helpful in predicting pathologic stage and patient outcome in prostate cancer.
Highlights the Bcl-2 protein which functions as a blocker of apoptosis and programmed cell death.
Expression of Bcl-2 is normally restricted to the basal cell layer of the normal and hyperplastic prostatic epithelium.
Overexpression of Bcl-2 is present in high-grade prostatic intraepithelial neoplasia.3,4
Identifies p53 (a regulator of the cell cycle) immunoreactivity in cancer cells.
Most immunohistochemical studies concluded that mutant p53 expression is a late event in localized prostate cancer,6-8 usually present in higher (>7) grade cancer.5,9,10
The cyclin-dependent kinase inhibitor (p27Kip1) negatively regulates cell proliferation.
Decreased p27Kip1 expression may be an independent predictor for cancer recurrence and long-term survival of prostate cancer.11-14
48, Caucasian, 5' 8",
, 190lbs, general good health.
PSA: 8-7-09 3.22, 11-13-09 4.25.
Biopsy: 32 cores. 3 cores reveal PCa, 10%, Gleason 3+3=6, T1C.
Current Treatment: Active Surveillance, next appointment Oct. 2010. No meat, no dairy, lots of fruits and vegetables.
Preferred Treatment: I just want someone to harvest my immune cells, genetically engineer them to fight my prostate cancer, and then infuse them back into my body...