Smoking and Prostate Cancer - Is it taboo?

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Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/5/2010 5:42 PM (GMT -6)   
In all my time here at HW Prostate Cancer, not sure I have ever seen a single thread discussing smoking and Prostate Cancer.  If there has been in the past, I apologize in advance.
 
In my research, like all things PC-related, studies seem to be a mixed bag.  Some studies indicate that smoking could be a contributing factor to getting PC, and then there are studies that disprove that.  Also, there are studies that show that smoking aggervates PC sufferers, and that smoking can lessen the effects of some PC treatments, i.e., HT.  But then again, still other studies don't make the link.
 
We hear a lot here, about the value or lack of value, of supplements, vitamins, etc," and we know that the studies there are a mixed bag as well.  The one thing that all of the doctors that I have ever met with since getting cancer, not just my current PC, but including cancers in my past, felt strongly, that if a patient isn't going to quit smoking, then all the other "healthy" life changes they make, are basicially void and secondary to quitting smoking.  That smoking alone, is far more damaging to a person's general health, then any of the other fixes that people try to better themselves with.
 
Me, I am an ex-smoker.  I only smoked from age 50-56, first pipes, then cigarettes.  Why so late in life?  Stupid reasons that aren't worth sharing.  But I quit cold turkey from a pack and a half a day habit the night before my open surgery.  So my last smoke was Oct 13, 2008.  Haven't had a puff or even a desire since.
 
Not interested in debating the merits of smoker's right, etc, just interested in how my other PC brothers feel about smoking.  Not a judgemental thing either, its not a moral issue with me, but as a cancer patient, where do you stand?
 
David in SC


Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


SubicSquid
Regular Member


Date Joined Oct 2009
Total Posts : 252
   Posted 6/5/2010 6:01 PM (GMT -6)   
I smoked from the age of twelve. Quit a two pack a day habit cold turkey in 1993 when I retired from the Navy (age 47). Having a mother and brother both of whom smoked and both of whom died from cancer, I think there is probably a connection somewhere. Mom had pancreatic cancer, brother, esophageal cancer. The hardest thing I found after quitting was having a beer without a smoke. Somehow, the two really go together. I would think that doctors would really frown upon a cancer patient smoking, although I have known men dying from lung cancer who smoked right up to the end (after disconnecting from the oxygen of course). At least there has been no link found yet between beer and cancer!!! Squid.
*Age 63, PSA July 2009 5.66
*Diagnosed July 2009, Biopsy: 2 of 12 cores positive, Gleason 3 + 5 = 8
*MRI and Bone Scan Negative.
*open Surgery October 22, 2009
*Prostate, both nerve bundles, seminal vessels, and lymph nodes removed during surgery.
*Post surgery Biopsy, Gleason 4 + 3; 2 positive margins
*Still slightly incontinant after 3 months - 1 pad per day (light). Dry at night. 1-2 trips to toilet.
*ED - Yes (will start Levitra possibly in January)
*30 day PSA (ultra-sensitive) .07
*90 day PSA (standard) <0.15
*01/10 - bladder neck stricture. opened during cysto exam. Cath #2 in for 5 days.
*03/01 - bladder neck stricture. Dilated during cysto exam. Cath #3 in place.
*03/11 - Bladder neck surgery. Cath #4 in place.
*03/15 - Cath #4 out. Great urine stream. Unfortunately, incontinence back to post surgery level.
*04/14 - Six month PSA - .21.
*05/15 - Incontinence basically under control.  99% dry.  Wear pad daily at work "just in case".
*06/10 - Started IGRT.   39 treatments scheduled.
 


keysailfisher
Regular Member


Date Joined Dec 2009
Total Posts : 347
   Posted 6/5/2010 6:08 PM (GMT -6)   
I don't know if it contributes to PCa but I'm sure it weakens your bodies immune system. I'm also ex smoker of 30yrs and quit 1 month before my surgery. Did it help ? Don't know but I wanted to have everything possible in my favor.
 
Neal
age 45
psa 3.09
Biopsy results 12/9
Left side base 3+3=6 21% 2/2 cores positive
Left side mid  3+3=6 100% 2/2 cores positive
Left side apex 3+4=7 88% 2/2 cores positive
Right side - 0/6
CT & Bone scan negative
Davinci Feb. 5th 2010/ cath removal 2/16
 
Gleason-3+4=7
Extent of tumor-Bilateral
Extraprostatic Extension-Absent
Seminal Vesicles-Negative for tumor
Surgical Margins-Rt apical margin focally positive
lymphovascular invasion-Suspicious in areas of capsular involvement
Regional lymph nodes-One node negative
Stage-T2c NO Mx
Incontinence-yes/ Down to 1 pad at 6 weeks out
11 weeks pad free
PSA 3/29/10 <0.01


BB_Fan
Veteran Member


Date Joined Jan 2010
Total Posts : 1011
   Posted 6/5/2010 6:23 PM (GMT -6)   
I haven't smoked cigerettes since 18. But I very much miss my weekly cigar during the summer months. I gave them up because "why take a chance". But I have to tell you I not too sure why I am so concerned when I an having CT scans, breast radiation and SRT. The ardiation will probably get me long before the period cigars.
Dx with PC Dec 2008 at 56, PSA 3.4


Biopsy: T1c, Geason 7 (3+4) - 8 cores taken with 4 positive for PCa, 30% of all 4 cores.

Robotic Surgery March 2009 Hartford Hospital, Dr Wagner
Pathology Report: T2c, Geason 8, organ confined, negitive margins, lymph nodes negitive - tumor volume 9%
nerves spared, no negitive side effects of surgery

One night in hospital, back to work in 3 weeks

psa Jun 09 <.01
psa Oct 09 <.01
psa Jan 10 .07 re-test one week later .05
psa Mar 10 .28 re-test two weeks later .31
psa May 10  .50

Aril 10 MRI and Bone Scan show lesion on lower spine, false positive. 
 
Started HT 5/25/10 with 3 month shot of Trelstar. SRT scheduled for late July


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/5/2010 6:33 PM (GMT -6)   
yes bb, i still remember the taste of a good pipe bowl, and cigar. even when i got hooked on cigarettes, never liked how they tasted, thought it was gross, it was all about the nic. but when i guit, i figured i had enough going against me, and for whatever future life i still had, and for the sake of my wife and family, i felt right about quitting,. i should add, despite my example, my wife and both my sons are smokers, my daughter never has. still comes down to a personal choice.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 6/5/2010 6:44 PM (GMT -6)   
I probably took up smoking at age 17 and was a pack and a half daily smoker by the time I gave it up at 28 (1976). Does it contribute to cancer development? Commonsense would make you think so. However, my father was one of 8 children, my mother was one of 7....I was one of five children. In my whole extended family including 35 first cousins (most of whom smoked for long periods), apart from me, only one of my aunts had a cancer (stomach ..... successfully treated back in the 1950's). Now heart disease.......that's a different story.
Bill

Post Edited (BillyMac) : 6/5/2010 5:48:10 PM (GMT-6)


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 6/5/2010 6:50 PM (GMT -6)   
I smoked from age 15 to 45, used smokeless tobacco at the same time for the last 15 years of that period. Not a day went by that I did not enjoy every single draw off it, and probably not many days went by that I didn't worry about it's effect on my health. Cancer, emphysema, etc. I spent 32 years in a chemical factory, with various fumes, and at times lint and other fibers, so that didn't help matters. Whether I got PCa from any of these unhealthy activites, I don't know. I'm the only one in my family on both sides that had had this disease, so not much record to go by. I live by the precept now that there's a lot in life that is just random, or bad luck or bad genes, however you wish to label it, but it boils down to bad things do happen to good people.

Funny you ask, as my 85 years old dad was just told yesterday that he has unoperable, terminal lung cancer, full of it in both lungs. He smoked from age 11 to age 70, and has used Copenhagen for the last 30 years. He also worked as a mason (cement dust), earlier in an asbestos gasket and brake factory for 2 years. So did any or all of this result in his situation today? Again, I just have to accept that bad things happen to good people. Conjecture on my part as to why bad things happen is futile for me. My grandfather -his father- smoked cigarettes and a pipe for 70 years and died peacefully of old age. He also ate foods fried in lard probably everyday of his adult life.
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 110 gms., margins clear
3 Years: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/5/2010 6:52 PM (GMT -6)   
Billy, know what you mean. Sure can vary within a family. My father, father in law, and mother in law, all died of smoking related cancer. My mother, just shy of 83, has been smoking non-stop for 67 years, and according to her PCP, still has good lungs. Go figure that.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


142
Forum Moderator


Date Joined Jan 2010
Total Posts : 7084
   Posted 6/5/2010 7:07 PM (GMT -6)   
I quit smoking early (abt. 3 years in college), but when the cost of cigs = cost of rent, I figured there was a problem. So I am not reformed, I just quit.

Lost three friends in the last two years to esophageal (sp?) cancer, all who smoked to the last,.

I've lived longer than most of the males in my family tree, none of whom ever had diagnosed PCa, so smoking did not change that.

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/5/2010 7:31 PM (GMT -6)   
James,

Sorry to hear about your father's dx, like my mother, he has lived a long life, but that is still a serious thing hanging over him and his family. I wish him the best possible under the circumstances. With the whole concept of cause and effect, its too difficult to prove what causes what harm and when and in what order, I agree. Aside from being in the military, with possible Agent Orange exposure in Nam, I was heavily exposed to highly carcenigenic liquids back in my early years when I worked as a machinist. In those days, they didn't have safety and haz warning sheets. You just did what you were told to on the job, in my case, I would be soaked from hand to elbow in liquid formylahyde for hours each night in the shop rinsing off metal parts. Could that have ultimately led me on the multi-cancer path I have been on? I will probably never know in this lifetime.

David in SC
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


Sleepless09
Veteran Member


Date Joined Jul 2009
Total Posts : 1267
   Posted 6/5/2010 10:37 PM (GMT -6)   
James, what rotten news about your dad.

May whatever time the two of you have left together be filled with great times and great joy for you both. My dad died 23 years ago, at 75, and a year before he died the job I had at the time ended. I spent his final year, with him every day, going to lunch, for a swim, a drive, whatever. Everyday we'd spend several hours together. The end of that job was such a blessing. When he died it was easy to part. Sad, but easy. We'd said what we had to say. He knew I loved him. I knew he loved me.

Sheldon AKA Sleepless
Age 67 in Apil '09 at news of 4 of 12 cores positive T2B and Gleason 3 + 3 and 5% to 25% PSA 1.5
Re-read of slides in June said Gleason 3 + 4 same four cores 5% to 15%
June 29 daVinci prostatectomy, Dr. Eric Estey, at Royal Alexandra Hospital Edmonton one night stay
From "knock out" to wake up in recovery less than two hours.  Actual surgery 70 minutes
Flew home to Winnipeg on July 3 after 5 nights in Ramada Inn  ---  perfect recovery spot!
Catheter out July 9
Final pathology is 3 + 4 Gleason 7, clear margins, clear nodes, T2C, sugeron says report is "excellent"
 
Oct 1st 09 -- dry at night, during day some stress issues.
Oct 31st padless 24/7 
 
First post op PSA Sept 09  less than 0.02
PSA on Oct 23 test again less than 0.02
PSA on Jan 8 less than 0.02
PSA on April 9 less than 0.02 
 
  


Sleepless09
Veteran Member


Date Joined Jul 2009
Total Posts : 1267
   Posted 6/5/2010 10:39 PM (GMT -6)   
David, on smoking.

I quit 43 years, six months ago.

I was two packs a day and I've no doubt it's left my body less able to cope. Who knows if my smoking contributed to my PCa, but I am sure it didn't help.

Quitting was the best thing I ever did --- aside from marrying my wonderful wife, that is.

Sheldon AKA Sleepless
Age 67 in Apil '09 at news of 4 of 12 cores positive T2B and Gleason 3 + 3 and 5% to 25% PSA 1.5
Re-read of slides in June said Gleason 3 + 4 same four cores 5% to 15%
June 29 daVinci prostatectomy, Dr. Eric Estey, at Royal Alexandra Hospital Edmonton one night stay
From "knock out" to wake up in recovery less than two hours.  Actual surgery 70 minutes
Flew home to Winnipeg on July 3 after 5 nights in Ramada Inn  ---  perfect recovery spot!
Catheter out July 9
Final pathology is 3 + 4 Gleason 7, clear margins, clear nodes, T2C, sugeron says report is "excellent"
 
Oct 1st 09 -- dry at night, during day some stress issues.
Oct 31st padless 24/7 
 
First post op PSA Sept 09  less than 0.02
PSA on Oct 23 test again less than 0.02
PSA on Jan 8 less than 0.02
PSA on April 9 less than 0.02 
 
  


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/5/2010 10:48 PM (GMT -6)   
Sheldon, I agree with you marrying our bride's part for sure.

I was kind of hoping that Tony, JohnT, and a few others that are very versed on cancer studies, PC in particular, woould weigh in here on this thread. Its an aspect I just haven't seen much attention given, yet with most other cancer types, its part of the normal advice given.

Curious what the experts think on this subject
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


John T
Veteran Member


Date Joined Nov 2008
Total Posts : 4269
   Posted 6/6/2010 4:53 AM (GMT -6)   
Smoking has a definate affect on Bladder Cancer, never saw anything connecting it to PC, but I'm sure some have tried.
I quit Cigs at 34 because I knew they were bad for me. Started Cigars about 10 years later and smoke about 5 a day, but since I don't inhale I trick myself into thinking they are not bad. I've given up meat and dairy, alcohol and caffine during my treatments, but hung on to my only pleasure, a good cigar. As soon as someone can prove a link they will also go , but till then I'll have a smoke at night and watch the river go by.
JT

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.

JohnT


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4849
   Posted 6/6/2010 5:28 AM (GMT -6)   
Ditto on the bladder cancer...When my surgeon found a little more then usual blood in my urine a few weeks ago - he said me being a smoker was why he was going to do the two tests I had.
 
I quit last summer and made it 8 months..Started again 2 months sgo..Going to attempt quitting again nono
Age 55   - 5'11"   215lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
05/18/10 - 24 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


Sephie
Veteran Member


Date Joined Jun 2008
Total Posts : 1804
   Posted 6/6/2010 7:00 AM (GMT -6)   
David, interesting question. We know that smoking can change the "nature" of healthy cells causing them to mutate. Not all smokers will develop cancer and not all non-smokers will not. We've probably all known smokers who live(d) to a ripe old age with no evidence of any cancer. We've also probably known people who "did everything right" yet still developed a deadly form of the disease. In these cases, something obviously changed in their body - was this change caused by genetics, environment, or just bad luck.

With all this said, I must fess up: I am a smoker and have been for far too many years. John does not smoke ... did my smoking contribute to his PCa? Don't know and probably never will. His dad smoked (unfiltered Camels, no less), had 3 heart attacks, stopped smoking at the age of 80, and died at the age of 88 from pneumonia. Go figure.
Husband diagnosed in 2/2008 at age 57 with stage T1c. Robotic surgery performed 3/2008. Stage upgraded to T3a (solitary focus of extraprostatic extension). Perineural tumor infiltration present. Apex margin, bladder neck and SVs negative. Final Gleason 3+4. PSA: 0.0 til July 2009. August 2009 - 0.1, September 0.3, October back to 0.0, December 0.0, March 2010 0.0. Next PSA in 6 months. Thank you God!


Sephie
Veteran Member


Date Joined Jun 2008
Total Posts : 1804
   Posted 6/6/2010 7:00 AM (GMT -6)   
David, interesting question. We know that smoking can change the "nature" of healthy cells causing them to mutate. Not all smokers will develop cancer and not all non-smokers will not. We've probably all known smokers who live(d) to a ripe old age with no evidence of any cancer. We've also probably known people who "did everything right" yet still developed a deadly form of the disease. In these cases, something obviously changed in their body - was this change caused by genetics, environment, or just bad luck.

With all this said, I must fess up: I am a smoker and have been for far too many years. John does not smoke ... did my smoking contribute to his PCa? Don't know and probably never will. His dad smoked (unfiltered Camels, no less), had 3 heart attacks, stopped smoking at the age of 80, and died at the age of 88 from pneumonia. Go figure.
Husband diagnosed in 2/2008 at age 57 with stage T1c. Robotic surgery performed 3/2008. Stage upgraded to T3a (solitary focus of extraprostatic extension). Perineural tumor infiltration present. Apex margin, bladder neck and SVs negative. Final Gleason 3+4. PSA: 0.0 til July 2009. August 2009 - 0.1, September 0.3, October back to 0.0, December 0.0, March 2010 0.0. Next PSA in 6 months. Thank you God!


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/6/2010 8:24 AM (GMT -6)   
JohnT - interesting about the bladder cancer link. My mother's PCP ran a series of tests on her bladder last year because of unexplained bleeding. The dr. said that the number one cause of bladder cancer was long term smoking. Her tests came back negative, the bleeding stopped on its on, and she back to smoking up to 2 packs a day. Not a story I am proud of.

I understand the cigar part. I think the danger is lip, mouth, and throat cancer, even if you don't inhale, and you are in direct contact physically with the tobacco leaf with cigars. But if this is what you enjoy, then enjoy. Sometimes I regret the many things I have given up for the sake of health.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/6/2010 8:30 AM (GMT -6)   
Steve, same thought on the bladder cancer as above. Hope its not the case.

Sephie, I would have figured that John was the smoker and you weren't, lol. Had that one in reverse. My wife smoked from age 14-21, then quit until she was 47, and started again and has ever since. Funny how people can be about it. You would think after 26 years of quitting, one would never want to smoke, but she said she never lost that nagging feeling for the nic in all those non smoking years.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


Ziggy9
Veteran Member


Date Joined Jul 2008
Total Posts : 981
   Posted 6/6/2010 8:34 AM (GMT -6)   
I quit for the last time 8 years ago. I had quit before but began dating a smoker who quickly got me smoking again. I still miss that morning cigarette. I started at age 15 so was it a factor in my getting Pca years later? Maybe but it would be along with other stronger factors IMHO like genetics and diet.

don826
Veteran Member


Date Joined May 2008
Total Posts : 1010
   Posted 6/6/2010 8:43 AM (GMT -6)   
Hi David,

I smoked from about age 13 to 18. Never a heavy smoker and experimented with cigars and pipes as well as the cigarettes. You know "cool factor". I went into the military at 18 and the first day of PT (physical training) I ran the mile. I was never a heavy smoker and was a track team member in high school. Anyway, after running the mile I came back to the barracks and lit up. Got so sick I thouhgt I was going to die. Last one I ever had. That was in 1968 and more than 40 years ago. Never had a hanker for one again and cannot stand to be around it. I guess that is what they call aversion therapy.

As far as health effects there is just to much research that suggests that smoking is detrimental to your health in many ways. There are probably connections we do not know about. Just look at pictures of the lungs of heavy smokers after years of smoking. Scary stuff.

Don
Diagnosed 04/10/08 Age 58 at the time
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan clear and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
Started Casodex on May 2 and stopped on June 1, 2008
Lupron injection on May 15 and every four months for next two years
Started IMRT/IGRT on July 10, 2008. 45 treatments scheduled
First 25 to be full pelvic for a total dose of 45 Gray to lymph nodes.
Last 20 to prostate only. Total dose to prostate 81 Gray.
Completed IMRT/IGRT 09/11/08.
PSA 02/08 21.5 at diagnosis
PSA 07/08 .82 after 8 wks of hormones
PSA 10/08 .642 one month after completion of IMRT, 6 months hormone
PSA 03/09 .38 six months post radiation and nine months into hormones
PSA 06/09 .36 or .30 depending on who did the test
PSA 09/09 .33 one year after IMRT and 16 months into hormone
PSA 03/10 .32 18 months after IMRT Still on hormones


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/6/2010 8:50 AM (GMT -6)   
Don, you are quite right. As far as one's general health, don't think anyone could justify smoking, too many facts out there.

Realziggy - I am a strong believer in the genetic and dna side of cancer causes. This is even a pet project with my long term PCP, he's convinced that all pre-disposition to cancers are already in one's genes. I am not knowledgable to know if that is possible or not My radiation oncologist felt that cancer is all in the genetics, and she is involved in some kind of on going research on the subject.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17


Ziggy9
Veteran Member


Date Joined Jul 2008
Total Posts : 981
   Posted 6/6/2010 9:07 AM (GMT -6)   
Purgatory said...
Don, you are quite right. As far as one's general health, don't think anyone could justify smoking, too many facts out there.

Realziggy - I am a strong believer in the genetic and dna side of cancer causes. This is even a pet project with my long term PCP, he's convinced that all pre-disposition to cancers are already in one's genes. I am not knowledgable to know if that is possible or not My radiation oncologist felt that cancer is all in the genetics, and she is involved in some kind of on going research on the subject.


I can see a time where many diseases will be treated before they develop through use of DNA and resulting genetic drugs. But we're likely born 20- 50 years too soon to matter for us. AS far as if there's a strong genetic factor in Pca that too will be told in years to come for our fathers grandfathers weren't tested much for it. I have a cousin on my maternal side who has Pca too. So does that mean it's genetic or not? Meanwhile neither of us have brothers and the other 2 male cousins on the same maternal side don't have Pca.

Sephie
Veteran Member


Date Joined Jun 2008
Total Posts : 1804
   Posted 6/6/2010 9:18 AM (GMT -6)   
David, sorry to hear that Peg went back to the 'butts' after so many years off them...yeah, it's a strong addiction. In a few hours, John and I leave for a cruise to Bermuda celebrating his 60th birthday (which was on Friday). Since smoking in our small cabin with no window or balcony is not something I want to subject John to, I hope to cut back considerably. Funny, when I go someplace that I can't smoke, I have little difficulty not lighting up for hours. But when I'm somewhere I can smoke and there are other smokers around me ... not good.

Oh well, hope springs eternal ... perhaps tomorrow is the day I'll decide it's time to quit.

Have a wonderful week all ... will check back in a week or so.
Husband diagnosed in 2/2008 at age 57 with stage T1c. Robotic surgery performed 3/2008. Stage upgraded to T3a (solitary focus of extraprostatic extension). Perineural tumor infiltration present. Apex margin, bladder neck and SVs negative. Final Gleason 3+4. PSA: 0.0 til July 2009. August 2009 - 0.1, September 0.3, October back to 0.0, December 0.0, March 2010 0.0. Next PSA in 6 months. Thank you God!


Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 6/6/2010 9:24 AM (GMT -6)   
I totally agree with you, Realziggy.

Most of this research will never help anyone directly of our generation. I am the only know case of PC on either side of my family, probably one reason I was totally ignorant on the subject at the start. But I also know, the generation before ours, men generally weren't tested, and most men would spend their entire lives avoiding doctors and hospitals in general. There may have been lots of PC in my family ,but will never know. Plus my doctor said, despite that, it still has to start some where. Because of me, now, both my adult sons have an automatic concern in their own lives, and have promised to have their first base test by age 35, or the next time either of them has to have any kind of blood workup.

With the lightning speed efforts that have been on genetics and dna, I can only imagine what it will be like 50 years from now, that might know from conception, everything that future human will ever be dealing with on the medical front in advance of their birth.
Age: 57, 56 dx, PSA: 7/07 5.8, 7/08 12.3, 9/08 14.5, 10/08 16.3
3rd Biopsy: 9/08 - 7/7 Positive, 40-90% Cancer, Gleason 4+3
Open RP: 11/08, Rht nerves saved, 4 days in hospt, on catheters for 63 days, 5th one out 1/09
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos margin
Incontinence:  1 Month     ED:  Non issue at any point post surgery, no problem post SRT
Post Surgery  PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, next one:  July
Latest: 7/9 met 2 rad. oncl, 7/9 cath #6 - blockage, 8/9 2nd corr surgery, 8/9 cath #7 out 38 days, 9/9 - met 3rd rad. oncl., mapped  9/9, 10/1 - 3rd corr. surgery - SP cath/hard dialation, 10/5 - 11/27 IMRT SRT 39 sess/72 gys ,cath #8 33 days, Cath #9 35 days, 12/7 - Cath #10 43 days, 1/19 - Corr Surgery #4,  Caths #11 and #12  same time, 2/8-Cath #11 out - 21 days, 3/2- Cath #12 out - 41 days, 3/2- Corr Surgery #5, 3/6 Cath #13 out - 4 days, Cath #14- 27 days, Cath #15 - 26 days, Cath #16 - 31 days, 5/24 put in Cath #17

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