Is cancer growing when PSA remains high?

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Regular Member

Date Joined Dec 2008
Total Posts : 25
   Posted 6/12/2010 1:18 AM (GMT -6)   
IF the psa is high in the 30's ...and goes to the teens on treatment, does it mean the cancer could still be doing destructive things to the bones? In other words, does having a high PSA mean the cancer is able to continue to work its way through the body?

Steve n Dallas
Veteran Member

Date Joined Mar 2008
Total Posts : 4849
   Posted 6/12/2010 2:54 AM (GMT -6)   
What type of treatment and when was it done?
It won't go from 30 to 0 overnight. Hopefully its on its way down to zero.
BUT, if its set in the teens and you still have cancer - it'll go back up.
Age 55   - 5'11"   215lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
05/18/10 - 24 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.

Regular Member

Date Joined Dec 2008
Total Posts : 25
   Posted 6/12/2010 6:12 PM (GMT -6)   
Lupron and Casodex 2008 Gleason 9 (5+4), then intermittent and went off meds 9/2009 but cancer came back 12/2009. . IF the PSA is set in the teens, I'm wondering if it's destroying bones even if it's in the teens.
Fibromyalgia, osteoarthritis, IBS, scoliosis

John T
Veteran Member

Date Joined Nov 2008
Total Posts : 4269
   Posted 6/12/2010 8:01 PM (GMT -6)   
If it is in the teens it may not be in the bones yet, but it certaintly is not going away and will most likely get worse with time. For HT to work psa needs to go to 0.05 and remain there for at least three months. If it does not do this then it indicates a large portion of the cells are androgen independent and will keep growing. See a good oncologist as there are other medications that may work.

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.


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