The American Urological Society has just held its annual meeting.
You may find it interesting to review some of the more relevant abstracts in the following link:
It would be good to get more detail on the non proprietary drugs tested in the study:
A STUDY FOR CHEMICAL ANALYSIS OF COUNTERFEIT PHSPHODIESTERASE TYPE 5 INHIBITORS IN KOREA
Kweon Min*, Busan, Korea, Republic of, Sae Kim, seoul, Korea, Republic of, Kwang Park, Kwangju, Korea, Republic of, Sung Lee, Seoul, Korea, Republic of, Jae Hyun, Jinju, Korea, Republic of, Ki Moon, Daegu, Korea, Republic of, Dae Yang, Seoul, Korea, Republic of, Sang Yang, Chungju, Korea, Republic of, Du Moon, Seoul, Korea, Republic of, Ji Ryou, Incheon, Korea, Republic of, Woo Chung, Seoul, Korea, Republic of, Myoung Kim, Jong Park, chunju, Korea, Republic of
Introduction and Objectives: Since sildenafil had developed at 1998, market of erectile dysfunction has been growing huge. This resulted in increasing and distributing counterfeit phosphodiesterase type 5 inhibitors (PDE5Is) smuggled in Korea. These drugs taken by the patients with erectile dysfunction could be critically harmful to them. It was aimed to analyze chemically counterfeit PDE5Is to evaluate a threat or harmfulness to the patients due to toxic materials or improper erectogenic materials.
Methods: The counterfeit PDE5Is sold without prescription in private market like adult shop or on-line market in Korea were enrolled. Doses of counterfeit Viagra are 100mg in 9 and 220mg in 3. Counterfeit Cialis are 20 mg in 1, 50mg in 1, 100mg in 3, 200mg in 1 and 220mg in 1. Shape and color of these 19 counterfeits were compared with genuine drugs obtained free of charge from Pfizer Pharmaceuticals Korea Ltd. and Lilly Korea Ltd. Analysis of components includes erectogenic active ingredients and toxic materials like 5 heavy metals, polychlorinated biphenyls, and benzopyrenes. Erectogenic active ingredients indicate approved components of PDE5Is like sildenafil and tadalfil and 10 unapproved active materials like homo-sildenafil, hongdenafil, amino-tadalfil, xantho-anthrafil, pseudovardenafil and etc. five heavy materials are mercury, lead, cadmium, arsenic and chrome.
Results: Counterfeits showed different size (32%) in tablet and different colors (42%) in tablet and solution compared to genuine Viagra and Cialis. They contained proper active ingredients including sildenafil and tadalafil in only one. Fifty eight percents contained an excess of quantity of active ingredient even by 2.4 folds compared to a genuine. Thirty seven percents showed no active ingredients at all. Ten unapproved erectogenic materials were not in all 19 drugs. Heavy materials were detected in 1 with lead and in 4 with mercury, but polychlorinated biphenyls and benzopyrenes were not.
Conclusions: Counterfeit PDE5 inhibitors could not be expected consistent efficacy by lack of proper active ingredients and could be administered as over dose, which might induce serious side effects.