Outcomes American Urological Society annual meeting

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GarryA
New Member


Date Joined Jun 2010
Total Posts : 5
   Posted 6/16/2010 2:31 AM (GMT -6)   
Dear All
The American Urological Society has just held its annual meeting.
http://www.aua2010.org/Attendees/am-pub.cfm

You may find it interesting to review some of the more relevant abstracts in the following link:
http://www.hisandherhealth.com/component/content/article/222-aua/618-here-are-major-articles-from-the-american-urological-association-annual-2010-meeting-



It would be good to get more detail on the non proprietary drugs tested in the study:

A STUDY FOR CHEMICAL ANALYSIS OF COUNTERFEIT PHSPHODIESTERASE TYPE 5 INHIBITORS IN KOREA

Kweon Min*, Busan, Korea, Republic of, Sae Kim, seoul, Korea, Republic of, Kwang Park, Kwangju, Korea, Republic of, Sung Lee, Seoul, Korea, Republic of, Jae Hyun, Jinju, Korea, Republic of, Ki Moon, Daegu, Korea, Republic of, Dae Yang, Seoul, Korea, Republic of, Sang Yang, Chungju, Korea, Republic of, Du Moon, Seoul, Korea, Republic of, Ji Ryou, Incheon, Korea, Republic of, Woo Chung, Seoul, Korea, Republic of, Myoung Kim, Jong Park, chunju, Korea, Republic of


Introduction and Objectives: Since sildenafil had developed at 1998, market of erectile dysfunction has been growing huge. This resulted in increasing and distributing counterfeit phosphodiesterase type 5 inhibitors (PDE5Is) smuggled in Korea. These drugs taken by the patients with erectile dysfunction could be critically harmful to them. It was aimed to analyze chemically counterfeit PDE5Is to evaluate a threat or harmfulness to the patients due to toxic materials or improper erectogenic materials.

Methods: The counterfeit PDE5Is sold without prescription in private market like adult shop or on-line market in Korea were enrolled. Doses of counterfeit Viagra are 100mg in 9 and 220mg in 3. Counterfeit Cialis are 20 mg in 1, 50mg in 1, 100mg in 3, 200mg in 1 and 220mg in 1. Shape and color of these 19 counterfeits were compared with genuine drugs obtained free of charge from Pfizer Pharmaceuticals Korea Ltd. and Lilly Korea Ltd. Analysis of components includes erectogenic active ingredients and toxic materials like 5 heavy metals, polychlorinated biphenyls, and benzopyrenes. Erectogenic active ingredients indicate approved components of PDE5Is like sildenafil and tadalfil and 10 unapproved active materials like homo-sildenafil, hongdenafil, amino-tadalfil, xantho-anthrafil, pseudovardenafil and etc. five heavy materials are mercury, lead, cadmium, arsenic and chrome.

Results: Counterfeits showed different size (32%) in tablet and different colors (42%) in tablet and solution compared to genuine Viagra and Cialis. They contained proper active ingredients including sildenafil and tadalafil in only one. Fifty eight percents contained an excess of quantity of active ingredient even by 2.4 folds compared to a genuine. Thirty seven percents showed no active ingredients at all. Ten unapproved erectogenic materials were not in all 19 drugs. Heavy materials were detected in 1 with lead and in 4 with mercury, but polychlorinated biphenyls and benzopyrenes were not.

Conclusions: Counterfeit PDE5 inhibitors could not be expected consistent efficacy by lack of proper active ingredients and could be administered as over dose, which might induce serious side effects.

Regards
Garry

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 6/16/2010 8:40 AM (GMT -6)   
Well, the links and the abstract is valid and accurate, so it's a legitimate study. This topic- brand names vs generics and online ordering has been raised several times recently, so the whole subject is on topic, as far as that goes. My spam detector sniffer isn't alerting to anything. There's no rules violations so there's nothing to be done.

Sharing new studies and reports from conferences are welcomed and serve a useful purpose and one from the American Urological Society is certainly legit. I see no attempt to influence or suggest any particular viewpoint by Gerry. So I say it's benefit of the doubt time.... smilewinkgrin
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 110 gms., margins clear
3 Years: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 6/16/2010 8:41 AM (GMT -6)   
Welcome to Healing Well Prostate Cancer Forum, Gerry. As you can see we are very spammer sensitive, so hope you don't feel falsely accused... Thanks for sharing the info and hope you will continue sharing your journey with us.
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 110 gms., margins clear
3 Years: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


GarryA
New Member


Date Joined Jun 2010
Total Posts : 5
   Posted 6/17/2010 8:02 PM (GMT -6)   
Hi James and other readers,
Ahh no I am not a spammer.
Within the conference discussion, you may also note,
the paper on:

5-ALPHA REDUCTASE INHIBITORS MAY INCREASE SPECIFICITY OF PSA TEST IN MEN WITH PREVIOUS NEGATIVE BIOPSY

i.e. the potent of increasingly sensitive PSA testing, with the direct aim of quantifying in a diagnostic sense, the extremely low post operative PSA readings.
An interesting quote:
“These studies mark the beginning of a new diagnostic approach to prostate-specific antigen,”


Garry

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 6/18/2010 10:37 AM (GMT -6)   
Gosh, Garry, you can speak research tech-talk! Are you gonna fit in here. Welcome and thanks for joining us. To create a signature to show a concise listing of your path (see, didn't use the Journey word... smilewinkgrin ) click the Control Panel, over on the left, then click the Edit profile when it shows, scroll to the bottom and type your info in the box, you can also add an email address, further up the screen, that is safe from spam bots and other nasties...
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 110 gms., margins clear
3 Years: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN

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