An example of a Clinical Trial that went bad using Chemo differently-Vogelzang 'not a good choice'

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 6/27/2010 5:40 AM (GMT -6)   
Just to show how not everything in trials is a known quantity or guarantees your safety. This comes from Howard Hansen a patient whom has done chemo and many other treatments in his journey with PCa and is the moderator of HRPCa, a group anyone herein can join, too.
----------------------------------------------------------------------------His post is this:

I posted this earlier, but recently Nick Vogelzang, MD was reviewing the abstracts from ASCO and he said this paper demonstrated that weekly taxotere is not a good choice which I’ll bet was based on the greater number of deaths in their weekly taxotere (36mg/m2 for 3 of 4 weeks) as compared to 3 weekly 75mg/m2 every 21 days. See the table below. Both arms were with DN-101. The ASCENT2 trial was ended early due to the number of deaths. 

So does higher dose make a difference in survival? Does use of DN-101 (somehow highly concentrated calcitriol) Make a difference. I wish I had an answer, but I don’t, so you will have to take this abstract for what it is. 

I’ve always used calcitriol as the little .5mcg pill, not this new formulation called DN101.  This was also with weekly taxotere 30mg/m2 3 weeks out of 4. I believe it has extended my survival, but I am but one person. The references for calcitriol and taxotere are at http://www.hrpca. org/chhdpc. htm ... I may have to revise this based on this new information.  This paper was not about 2nd line chemotherapy which is the way I have used it and my dose was lower.

It would nice to see a clinical trial with true apples to apples comparison. 

Take care  (Howard)------------------------------------------------------------------------------


Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 6/27/2010 9:11 PM (GMT -6)   
Thanks Bob,
Nick is my guest speaker for August at UsTOO. I am not sure I understand the specific questions Howard has, but I can raise the question to Dr. V and get his take on why the comparison is the way it is. You have my contact information, please feel free pass it along to Howard.

Advanced Prostate Cancer at age 44 (I am 47 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

LARP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog :

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 6/28/2010 6:52 AM (GMT -6)   
Great meeting that should be, anytime you can get a class professional PCa oncologist and especially face to face with patients, that are literally dying for answers is awesome and inspirational even if their specific needs are not met. Seen Nick Vogelzang on the video conferences and such, along with Strum, Meyers,Scholz and such folks...collectively probably the finest on the biology of PCa we can find. When you hear them discuss a patients assessment and how to treat that patient, and when they all concurr and we see their uro-doc had a different plan for that patient....shows how important assessment and opinions are.

Will get you Howards personal email address.
Youth is wasted on the Young-(W.C. Fields)

New Topic Post Reply Printable Version
Forum Information
Currently it is Saturday, September 22, 2018 2:04 PM (GMT -6)
There are a total of 3,005,699 posts in 329,254 threads.
View Active Threads

Who's Online
This forum has 161797 registered members. Please welcome our newest member, paulwhiff.
269 Guest(s), 7 Registered Member(s) are currently online.  Details
HeartsinPain, PeterDisAbelard., Artist Mark, ppm guy, Anitas, 18yearsandcounting, oregonhay