PSA Reading false or real

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New Member

Date Joined Jun 2010
Total Posts : 2
   Posted 6/28/2010 4:14 PM (GMT -6)   
I am a 66 year old male with no family history of prostate cancer. 
Last several years my PSA has been steady 1.2-1.5 (no upward trend).  In May urologist through DRE determined one side of prostate was harder than the other so he felt that a biopsy should be performed 1 June 2010-- (a week or so before biopsy PSA was 1.4).  Biopsy was negative in all quadrants tested (12 sites were tested).  I have and have had BPH for the last couple of years.  Doctor ordered a PSA after the biopsy and this was completed last week 28 June 2010 with a reading of 4.6 (3 weeks after biopsy).  I have trouble comprehending this reading since there has never been a high reading in my history.  Could this reading be more of a false reading than a true reading.  Thanks...

Regular Member

Date Joined May 2010
Total Posts : 264
   Posted 6/28/2010 4:34 PM (GMT -6)   
Someone more knowledgeable than me will chime in but the biopsy is a very invasive procedure for the prostate. Since doctors recommend waiting 4,6 or even 8 weeks to have a prostatectomy done after a biopsy and since having blood in the semen for 3 weeks afterwords is common, I would not be surprised if your PSA reading is still elevated because of the trauma to the prostate during the biopsy.

Let us know what you find out.

Here are some of my stats:
Father diagnosed with PC at age 72 - wasn't contained to prostate when found in 1992.
My PSA rose from 3.2 to 5.1 over the course of 1.5 years with Free PSA at 25% for the last two tests.
DRE showed no evidence of tumor but Uro thought my prostate was a little large for someone my age
PCa diagnosed 4/6/10 after biopsy on 4/1/10
1 out of 12 biopsy samples was positive with 5% of biopsy sample cancerous
Gleason 3+4
Da Vinci surgery on 6/1/10
Pathology report shows cancer confined to prostate and all other tissue clean

Veteran Member

Date Joined Jul 2008
Total Posts : 966
   Posted 6/28/2010 4:38 PM (GMT -6)   
First and foremost...Welcome to Healingwell.

I would agree with Dan on this. The prostate is inflammed and will be for several months. Any PSA test within six weeks of the biopsy will be misleading. It is also worth mentioning that BHP will also raise the psa levels in addition to any infection that may have occurred with the biopsy.

I would wait several more weeks or even the standard three months from biopsy to get another test. The good news is that the biopsy came back negative.

Again...welcome to Healingwell
You are beating back cancer, so hold your head up with dignity
Age 58 at Diagnosis
Oct 2006 - PSA 2.6 - DRE Normal
May 2008 - PSA 4.6 - DRE Normal / TRUS normal
July 2008 - Biopsy 4 of 12 Positive 5 - 30% Involved Bilateral w/PNI - Gleason (3+3)6 Stage T1C
Robotic Surgery Sept 18, 2008
Pathology October 1, 2008 - Gleason 7 (3+4) Staged pT2c NO MX - Gland 50 cc
Seminal Vesicles and Lymph Nodes clear
Positive Margins Right Posterior Lobe
PSA 5 week Oct 2008 <.05
                   3 month Jan 2009     .06
                   6 month Apr 2009     .06
                   9 month Jul  2009     .08
                 12 month Oct 2009     .09 
                 18 month April 2010   .19

New Member

Date Joined Jun 2010
Total Posts : 2
   Posted 6/28/2010 5:01 PM (GMT -6)   
Dan & Les

Thanks for the info. I could not understand an increase in the PSA from 1.4 to 4.6 in such a short time. Especially since the last 3 years or so my PSA has been very steady despite BPH. I am looking to arm myself with information before the next Dr's appointment where he wants to discuss this "elevated psa". You info is valuable and helpful.


Veteran Member

Date Joined Jan 2010
Total Posts : 2845
   Posted 6/28/2010 5:47 PM (GMT -6)   
I agree with the postings above - when you have decided the wait is long enough to have another PSA - make sure you do not ( someone may correct me) have sex for 2-3 days before hand - this includes massterbation as well as inntercourse ( I can spell but the forum has a naughty word programme) - or another DRE....
-all the best


p.s. I googled - when to have a psa after a biopsy and found this site - regarding non-cancerous causes for high PSA -

Age: 54 - gay - with common-law spouse of 13 years, Steve - 60
PSA: 04/2007- 1.68 - 08/2009 - 3.46 - 10/2009 - 3.86
Confirmation of Prostate Cancer: October 16, 2009 - 6 of 12 cancerous samples , Gleason 7 (4+3)
Doctor: Dr. Mohamed Elharram -Urologist / Surgeon - Peterborough Regional Health Centre
Radical Prostatectomy Operation: November 18, 2009 , home - November 21, 2009
Post Surgery Biopsy: pT3a- gleason 7 - extraprostatic extension - perineural invasion - prostate weight - 34.1gm -
ED Prescription: Jan 8/2010 - started daily 5mg cialis - girth back to normal -but not much length - will go for trimix in April when I see doc
Incontinence: Feb 2010- 3-5 pads/1-2 clothes changes/day- March 3, 2010 - week 14 after surgery -finally seeing improvement - March 29- incontinence better - 1-2 pads a day - one pad at night - May 25 - 1 pad during day - 1 pad at night for security (barely needed at all) - stress incontinence at work - lifting trees and shrubs...
location: Peteborough, Ontario, Canada
Post Surgery-PSA: - April 8, 2010 - 0.05 - I am in the ZERO CLUB - hooorah!
Next PSA - October 8, 2010 - TBA -

John T
Veteran Member

Date Joined Nov 2008
Total Posts : 4269
   Posted 6/28/2010 7:08 PM (GMT -6)   
I would think that psa should be back to normal levels 6 to 8 weeks after a biopsy. Any readings sooner than that are sure to be affected by the biopsy.

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.


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