Dr. Myers and Provenge (and PSA of 2700)

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Gordy
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Date Joined Jun 2005
Total Posts : 528
   Posted 7/16/2010 9:13 AM (GMT -6)   
Especially for those who've given up hope:

http://askdrmyers.wordpress.com/2010/07/07/provenge-case-study/

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/16/2010 9:15 AM (GMT -6)   
askdrmyers.wordpress.com/2010/07/07/provenge-case-study/

Link activated...

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino


zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 7/17/2010 9:23 AM (GMT -6)   
Gordy or Tony or others could you summarize what is in this link, I had to drop my Comcast provider and currently have low priced and lousier Netzero (they don't have the DSL version yet in my area) and didn't get to read this, it would not finish loading to see it in my situation. Wouldn't mind knowing the moral of the story, so to speak. May have to get faster internet soon.


Gordy
Veteran Member


Date Joined Jun 2005
Total Posts : 528
   Posted 7/17/2010 10:50 AM (GMT -6)   
Dr. Myers talks about a patient who'd been on a Provenge trial, then Taxotere and had a PSA of over 2700 with bone mets in December 2008. Myers put him on Estradial + Ketoconazol + Lukein and by April 2009 his PSA was 110. In November his disease showed some progression, but Myers thinks he knows why and what to do about it (but doesn't tell us). He realizes this is very anecdotal but feels that pre-treating with Provenge will turn out to be a very effective tool in severe cases.

-Les

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 7/17/2010 12:18 PM (GMT -6)   
Thanks Gordy for the explanation that is one of most aggressive protocols I have every heard about, results is the important factor. Robert Young (founder of www.Phoenix5.org) was originally diagnosed with psa of over 3000, had bone pains (mets)and went in for checkup only find his scenario on PCa. He did manage to live 3 yrs. fighting PCa and helping others in that process, a great guy and website still surviving many years later. Less protocols used back in 2000 era, too.
Youth is wasted on the Young-(W.C. Fields)


Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 7/17/2010 1:01 PM (GMT -6)   
It's important to note that experimental drugs in clinical trials are tested with very specific protocols during the trials. Once a drug is approved for use by the FDA it is with those specific protocols in the trials used to get the drug approved. Abiraterone is one such example. In the trials for that drug, patients had to have failed chemotherapy and were castration resistant in their disease. What we won't learn from the trial is if using the drug early on, such as before chemo, or before the disease becomes refractory, would reap better results.

This is precisely where we are with Provenge. While approved for patients that have failed chemo and have HRPC, they are the only candidates for this treatment. Nick Vogelzang told me that he was happy the drug was released, but that we may be missing a very huge opportunity in identifying if the drug could even prevent the ONSET of prostate cancer in know cases of hereditary disease. Or even that Provenge could be better used before chemotherapy.

This is where great researches from the prostate arena make great oncologists. We do need the FDA to monitor controlled releases of drugs, but once they are released, we need our top oncologists to control the next studies, through the FDA, to see if there are better ways to use the drugs.

While this is only one patient that Myers is treating, we can do better getting this information in a database for our top oncologists.

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

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