Starting on trimix

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reachout
Veteran Member


Date Joined May 2009
Total Posts : 725
   Posted 7/22/2010 7:55 PM (GMT -6)   
My urologist gave me 30cc of trimix in his office as a test a month ago, and it worked pretty well but I had pretty bad aching.  He said the aching would get better over time, and asked me to come back once he had mixed up a batch for me to take home.  This is a real advantage for me, because he mixes it up at the military clinic where I go.  I returned a couple of weeks ago and he gave me the 30cc again, and this time it didn't ache as much, but I didn't think it was strong enough for penetration.  He said to increase the dose to 35 then to 40 and if that didn't work to go back to see him.
 
I tried it at home a week ago, at 30 cc, and it was about the same as at the doctors office, good response but not enough for penetration.  The erection lasted about 1 1/2 hours, which the doctor said was the right duration.
 
Yesterday I increased the dose to 35cc and it did the trick, strong enough for penetration.  It lasted almost two hours, and it didn't ache as much as the first time but it was still pretty tender.  When I put on my pants, just the pressure of the clothing made it ache, so I wore pretty lose clothes until it went down.
 
The feeling was good, although to be honest it didn't feel quite the same as a natural erection.  The main difference, I think, is the ache that I feel when there is any pressure on.  I hope that decreases over time.  Doc wants me to try it a couple of times a week and go back to see him in two months.
 
All in all my wife and I are very grateful for the trimix, it gives us renewed hope for the ED after surgery.  This is the last problem we have, since the PSA is still 0 and I remain continent.
Age 64 yrs
DX 5/2009
8 out of 12 cores positive
PSA 5.6
Gleason Score 3+4=7
Stage T2a
Da Vinci Surgery 08/07/2009
Upgrade Gleanson Score 4+3=7
Stage pT2c
Neg Margins and Nodes
Extracapsular extension noted but neg Extraprostatic Extention (??)
Dry immediately
Daily Cialis 5mg slow recovery
First PSA 3 Nov 09 <0.1
Second PSA 2 Feb 10 0.01
Third PSA 1 Apr 10 <.014
Fourth PSA 19 May 10 <0.1


Steve n Dallas
Veteran Member


Date Joined Mar 2008
Total Posts : 4829
   Posted 7/23/2010 3:54 AM (GMT -6)   
Thank goodness for Trimix. I have only used 10cc's...
 
ED pills do next to nothing for me AND give me a nasty headach.
Age 55   - 5'11"   215lbs
Overall Heath Condition - Good
PSA - July 2007 & Jan 2008 -> 1.3
Biopsy - 03/04/08 -> Gleason 6 
06/25/08 - Da Vinci robotic laparoscopy
05/14/09  - 4th Quarter PSA -> less then .01
11/20/09 - 18 Month PSA -> less then .01
05/18/10 - 24 Month PSA -> less then .01
Surgeon - Keith A. Waguespack, M.D.


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 7/23/2010 7:20 AM (GMT -6)   
Congrats on the first use of trimix. Read around here and see about how we use the plump and inject method. This method should reduce the amount needed while providing a much better quality erection. Basically, it is holding the blood in the penis, either using a pump and ring at about 1/3 erect, or using a milking motion to force blood into the penis, then manually holding the base to keep the blood in, allowing for opening of the cavernous cavities and for the drug to have time to adsorb and work, before it flows back into the blood stream, as this is what happens because our penile outflow valves aren't working properly yet. Give it a try and see. Some will substitute a proper sized office rubber band to work just as well. The main point is to fill the penis with some amount of blood and then to hold the drug in this until it has time to be adsorbed. A litle stimulation along the way once the blood is released will increase the hardness and time it works.
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 110 gms., margins clear
3 Years: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


reachout
Veteran Member


Date Joined May 2009
Total Posts : 725
   Posted 7/23/2010 8:05 AM (GMT -6)   
Thanks a lot, James, I did a search on "plump and inject" and there is a world of information there. I will try this method next time. Last time I injected I noticed the needle went in very easily and I injected from the 35 mark down to the 20 mark and at that point I got resistance. I didn't know what to do so I pushed a little harder and then the rest went in. After reading about the mechanics of injecting, maybe the needle had gone through the cavenous cavity into the other side of the cavity and that's why I felt resistance. There was no pain, and it still worked, but that felt strange.

I was also wondering why I'm at 35cc and so many other guys here, like Steve and yourself, are at half that or less. So maybe this new method will decrease my dosage, but I wonder if trying the plump and inject with my current dosage would result in a 4 hour problem? Maybe I should cut back to 30 with the plump and inject and try that.

Wish they could give us an antidote that we could inject ourselves with in the case of a 4 hour erection. I know the sudafed is supposed to work but if it doesn't and we need to go to the ER for a shot, why not have whatever they use in stock and we could inject it ourselves? I wonder if any doctors give that, but maybe it's too dangerous to try at home.
Age 64 yrs
DX 5/2009
8 out of 12 cores positive
PSA 5.6
Gleason Score 3+4=7
Stage T2a
Da Vinci Surgery 08/07/2009
Upgrade Gleanson Score 4+3=7
Stage pT2c
Neg Margins and Nodes
Extracapsular extension noted but neg Extraprostatic Extention (??)
Dry immediately
Daily Cialis 5mg slow recovery
First PSA 3 Nov 09 <0.1
Second PSA 2 Feb 10 0.01
Third PSA 1 Apr 10 <.014
Fourth PSA 19 May 10 <0.1
Starting trimix July 10


MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 7/23/2010 8:56 AM (GMT -6)   
Reachout,

Pick yourself up an auto-injector, it totally takes any guesswork out of the injection process

The reason why you are using more medication is easy, the medication is escaping via bloodflow before it can get absorbed into both chambers. Constricting the blood flow means that more medication is distributed and absorbed before bloodflow can flush it out. You will use less medication this way

The antidote is Sudafed, NOT the PE version. The one that contains Pseudoephedrine and is only available behind the counter, no Rx necessary but they may ask to see ID before sale
Stats:
Age: 52, PSA (2008)=1.9
Biopsy on 01/09/09, Gleason Score = 3+3
One (1) out of twelve (12) cores was positive, plus external nodule found
Surgery (Da Vinci, robotic prostatectomy): 4/7/09
Post Op Path 3+3
Removed Catheter: 04/19/09
100% bladder control - Pad free 7/09
PSA 7/09 undetectable, <0.01 - 3 months post-op
PSA 1/10 undetectable, <0.01 - 9 months post-op
Trimix provides 100% erectile function


reachout
Veteran Member


Date Joined May 2009
Total Posts : 725
   Posted 7/23/2010 10:08 AM (GMT -6)   
Awesome, I looked at posts for the Inject-Ease and am going to order one.  It seems pretty simple to use, but have just a couple of questions that are not clear to me. 
 
I assume that I still load my hypodermic with the solution to the required amount then place the entire hypodermic in the autoinjector, right?  I mean, rather than having the autoinjector load it for me and worry me that it took in the right amount.
 
Second, my doc was pretty emphatic about using alcohol swabs to clean the top of the trimix bottle before I loaded the syringe, to also wipe clean the point where I am going to inject,  and to keep the needle away from touching anything until I inject.  Swiping the bottle and the injection area are not a problem but when you use the autoinjector, is it easy to keep the needle from touching anything on the autoinjector?  After all, if the same device is used all the time, it could pick up germs right?
Age 64 yrs
DX 5/2009
8 out of 12 cores positive
PSA 5.6
Gleason Score 3+4=7
Stage T2a
Da Vinci Surgery 08/07/2009
Upgrade Gleanson Score 4+3=7
Stage pT2c
Neg Margins and Nodes
Extracapsular extension noted but neg Extraprostatic Extention (??)
Dry immediately
Daily Cialis 5mg slow recovery
First PSA 3 Nov 09 <0.1
Second PSA 2 Feb 10 0.01
Third PSA 1 Apr 10 <.014
Fourth PSA 19 May 10 <0.1
Starting trimix July 10


eggbe
Regular Member


Date Joined Feb 2010
Total Posts : 33
   Posted 7/23/2010 12:01 PM (GMT -6)   
I tried an auto injector but found the downward pressure I had to apply to arm the device caused me to miss the injection target and ended up sending the dose to the uretha, there may be others that don't require such pressure to arm but after that I realized I like the control and ability to visual see exactly where the dose is going.
age 59 psa 6.3 Nov 2009
gleason 7 (4+3) Dec 2009
HIFU 1-17-10
PSA 0.2 3-4-10 (before recommended 3 months wait)
PSA 0.1 4/14/10


RCS
Veteran Member


Date Joined Dec 2009
Total Posts : 1247
   Posted 7/23/2010 1:18 PM (GMT -6)   
Reachout,
 
If the needle bothers you, like it did me, you may want to consider the possibility of using a smaller needle.  I've gone to a 1/2" (length) needle; 30 Gauge; insuline syringe ... because it is so small I can barely feel it.
 
Also, you wondered why your dosage was higher than others.  I guess you will find the amount of Trimix you need will drop with time.  I Started at 10 units (way too much) and found 3.5 units worked well for several months.  I'm now at 2 units.  At this rate a 5 cc vile will last way past its expiration date (250 doses).
 
Also, you say you are inecting 30 cc, this seems like a lot.  The biggest syringe I've used only holds 1 cc.  Maybe you mean 30 units (1 cc = 100 units)?
PSA 2007 - 2.8
PSA 11/24/2008 - 7.6
Pc Dx 2/11/09; age at Dx 62
RLP 4/20/09
Biopsy -  Invasive moderately differentiated prostatic andenocarconoma; G 3+3=6; PT2C; No evidence of Seminal Vesicle or Extraprostatic Involvement; Margins clear; Tumor identified in sections from prostatic apex.
70 gram prostate.
Immediately continent after removal of cath.
ED - Trimix works well; viagra @ 70%
PSA - 7/31/09 <0.06
PSA - 12/1/09 <0.06
PSA - 3/29/10 <0.06
 
 
 


James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4462
   Posted 7/23/2010 1:43 PM (GMT -6)   
If you do the plump and prick method, you can drop down to a 31 ga., 5/16 inch insulin needle, unless you have an unusually thick penis. When you do inject, if plumped, you will feel the needle "drop" into the cavity, as there will be no resistance when you do. This method helps with accuracy and with becoming painfree. Easier to know just where you are sticking it and when you are doing it properly and successfully. If you try this method, how about starting out with about 10 units, or .10cc and work up, it's gonna be trial and error until you find your sweet spot. devil
James C. Age 63
Gonna Make Myself A Better Man www.youtube.com/watch?v=a6cX61oNsRQ&feature=channel
4/07: PSA 7.6, Recheck after 4 weeks Cipro-6.7
7/07 Biopsy: 3 of 16 PCa, 5% invloved, left lobe, GS3+3=6
9/07: Nerve Sparing open RRP, 110gms, Path Report- Stg. pT2c, 110 gms., margins clear
3 Years: PSA's .04 each test since surgery, ED continues: Bimix- .3ml PRN, Trimix- .15ml PRN


vam4710
Regular Member


Date Joined May 2010
Total Posts : 89
   Posted 7/23/2010 3:18 PM (GMT -6)   
Man....I hope that Cialis works for me when I get started... I can't imagine jabbing "johnny" with a needle. I don't do well with needles to beging with shocked
Diagnosis June 1, 2010 @ age 50
PSA  1.7    Sept. 2008
PSA  2.14  Sept. 2009
PSA  2.75  April  2010
 
May  25, 2010  - Biopsy  1 of 12 cores positive;  Gleason 3+4 = 7  25%;   Stage T1c
June 04, 2010  - CT and Bone scan - All Negative
July  07, 2010  - Da Vinci Robotic Lap. Surgery
 
PATHOLOGY
Tumor involvement - 15% both right and left halves
Gleason 3+3=6
Seminal Vesicles - Negative
Lymphnode - Negative
Subcapsular perineural Invasion - Present
Bladder Neck Margin Positive (right posterior) - 1mm Focus
pT3a-N0-MX
 
Incontinence - Dry at night, 2 or 3 pads during the day (looks like the Kegels before surgery paid off)
 
ED  - Total flat tire.... no spare, not even a donut
 
First PSA scheduled for 10/14
 
 
Northern NJ


reachout
Veteran Member


Date Joined May 2009
Total Posts : 725
   Posted 7/23/2010 3:28 PM (GMT -6)   
RCS said...
Also, you say you are inecting 30 cc, this seems like a lot.  The biggest syringe I've used only holds 1 cc.  Maybe you mean 30 units (1 cc = 100 units)?
 
Oops, that's what I meant, 30 units.  Glad they idiot proof this stuff.
 
 
vam, it's not that bad.  Just think of the positives.  If you're in a bad part of town and drug addicts are bragging about where they inject, you can tell them they're wimps and they ain't seen nothing yet :-)   (keeping a sense of humor about this)

Age 64 yrs
DX 5/2009
8 out of 12 cores positive
PSA 5.6
Gleason Score 3+4=7
Stage T2a
Da Vinci Surgery 08/07/2009
Upgrade Gleanson Score 4+3=7
Stage pT2c
Neg Margins and Nodes
Extracapsular extension noted but neg Extraprostatic Extention (??)
Dry immediately
Daily Cialis 5mg slow recovery
First PSA 3 Nov 09 <0.1
Second PSA 2 Feb 10 0.01
Third PSA 1 Apr 10 <.014
Fourth PSA 19 May 10 <0.1
Starting trimix July 10


vam4710
Regular Member


Date Joined May 2010
Total Posts : 89
   Posted 7/23/2010 6:09 PM (GMT -6)   
reachout said...
RCS said...
Also, you say you are inecting 30 cc, this seems like a lot.  The biggest syringe I've used only holds 1 cc.  Maybe you mean 30 units (1 cc = 100 units)?
 
Oops, that's what I meant, 30 units.  Glad they idiot proof this stuff.
 
 
vam, it's not that bad.  Just think of the positives.  If you're in a bad part of town and drug addicts are bragging about where they inject, you can tell them they're wimps and they ain't seen nothing yet :-)   (keeping a sense of humor about this)

 

Hahahaha.....good one!!


Diagnosis June 1, 2010 @ age 50
PSA  1.7    Sept. 2008
PSA  2.14  Sept. 2009
PSA  2.75  April  2010
 
May  25, 2010  - Biopsy  1 of 12 cores positive;  Gleason 3+4 = 7  25%;   Stage T1c
June 04, 2010  - CT and Bone scan - All Negative
July  07, 2010  - Da Vinci Robotic Lap. Surgery
 
PATHOLOGY
Tumor involvement - 15% both right and left halves
Gleason Down graded to 3+3=6
Seminal Vesicles - Negative
Lymphnode - Negative
Subcapsular perineural Invasion - Present
Bladder Neck Margin Positive (right posterior) - 1mm Focal protrusion
pT3a-N0-MX
 
Incontinence - Dry at night, 2 or 3 pads during the day (looks like the Kegels before surgery paid off)
 
ED  - Total flat tire.... no spare, not even a donut
 
First PSA scheduled for 10/14
 
 
Northern NJ


Jstars
Regular Member


Date Joined Oct 2005
Total Posts : 489
   Posted 7/23/2010 6:30 PM (GMT -6)   
As RCS said your syringe is probably 1 CC TOTAL so the little units marks are just divided by 100. Just another demonstration of Metrically challenged Americans. How can we compete with the rest of the metric world, eh?

I can't get it out of my head this giant 35 cc cartoon syringe with a needle the size of a swizzle straw!!! Would surely be enough for ol Willie to shrink up on sight into your crotch and never come out again!

But good luck with 'jectin.
Age 59, 57 at DX, PSA Aug2008 7 4 ... June2007 4.7 (BPH + LUTS)
11/2008 Biopsy: 1 of 12 cores 5%, Gleason 3+3 - Sona showed size 140+ cc (110 grams post op).
02/03/09 open RRP surgery ,Nerve sparing, 1 day in hospital.
02/18/09 Cath out -- passed 1 cm oblong bladder stone (not kidney!).
Pathology Report: All margins clear - No Invasive spread - no change in Gleason score.
04/09, 07/09, 10/09, 01/15/10 PSA <0.1
03/2009 Levitra@20mg / Viagra@100mg/Cialis@20mg -- (nocturnal stirrings started 02-03/2010).
08/09-09/09,02-03/10 MUSE@1000mcg 80-90% (with some ache )
10/09-11/09 TrimixGel@(500/300/100mcg): 60,70,80%,
02/10-03/10 TrimixGel@1000/300/100mcg - 80-90% - just @ usefulness.
Gel + MUSE 500mcg -- 100% for 30-60 mins and 80-90% for hours after that).


reachout
Veteran Member


Date Joined May 2009
Total Posts : 725
   Posted 7/30/2010 2:52 PM (GMT -6)   
Here's a great big thank you to all you guys.  I tried the method you suggested, and had a full liftoff and successful mission!  Felt just like the old days.  Don't get me wrong, I would just as soon never have had PC but, since I had it, it's good to know at my age that I have a method to perform sort of on command.
 
Better living with chemistry.  yeah

PSA history:

May 2005 2.7

Mar 2006 3.2
10 May 2007 4.1
24 May 2007 2.9
20 Jun 2007 3.3
Sep 2007 2.6
Jul 2008 3.8
May 2009 5.6, followed by biopsy (age 64)

8 out of 12 cores positive Gleason 3+4=7 Stage T2a
Da Vinci Surgery 08/07/2009
PathologyuUpgrade to Gleason 4+3=7 Stage pT2c
Neg Margins and Nodes
Extracapsular extension noted but neg Extraprostatic Extention (??)
Dry immediately
Daily Cialis 5mg slow recovery
First PSA Nov 2009 <0.1
Second PSA Feb 2010 0.01
Third PSA Apr 2010 <.014
Fourth PSA May 2010 <0.1

Still dry but pills for ED don't work well

Starting trimix July 10
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