The median time of the study was 7 years, but here is the 12 year data from the study and it is pretty good.
bPFS was most closely related to the percentage of positive biopsy specimens and the patient’s risk group.
The patient’s Gleason score was the strongest predictor of CSS.
OS was best predicted by patient age, hypertension, diabetes, and tobacco use.
At 12 years, biochemical failure and prostate cancer-specific mortality were
1.8 and 0.2 percent, respectively, for patients with a Gleason score of 5 or 6
5.1 and 2.1 percent, respectively, for patients with a Gleason score of 7
10.4 and 7.1 percent, respectively, for patients with a Gleason score of ≥8.
Tony, no matter how much data is provided on any treatment other than surgery, you will always discount it. Any treament that has 12 year cure rates of 1.8%, 5.1% and 10.4% for low, medium and high risk PC with relatively few side affects can't be brushed off. Scardino in his book admits that of all the surgeries done at MSK 40% are clasified as unsuccessful, defined as no cure, permanent side affects or major complications, and this is one of the top surgical center is the US.
64 years old.
PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.
2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.
Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.
Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.
25 treatments of IMRT 6 weeks after seed implants. No side affects at all.
PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.