Statins and PCa recurrence

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RCS
Veteran Member


Date Joined Dec 2009
Total Posts : 1247
   Posted 8/1/2010 11:39 AM (GMT -6)   
Today's USA Weekend Magazine (supplemement in the Denver Post) has an article by Dr. Ted Mitchell concerning the use of statins and PCa.  He sites an American Cancer Society report:
 
"From 1996 to 2008, researchers followed 1,319 men who had their prostates removed for cancer treatment.  At the time of their surgery, 236 of them were taking statins (cholesterol-lowering drugs).  At the study's end, researchers determined that those men were 30% less likely than the other 1,083 men in the study to have a recurrence of their tumor.  Those men taking the highest dose of statins saw the greatest reduction."
 
PSA 2007 - 2.8
PSA 11/24/2008 - 7.6
Pc Dx 2/11/09; age at Dx 62
RLP 4/20/09
Biopsy -  Invasive moderately differentiated prostatic andenocarconoma; G 3+3=6; PT2C; No evidence of Seminal Vesicle or Extraprostatic Involvement; Margins clear; Tumor identified in sections from prostatic apex.
70 gram prostate.
Immediately continent after removal of cath.
ED - Trimix works well; viagra @ 70%
PSA - 7/31/09 <0.06
PSA - 12/1/09 <0.06
PSA - 3/29/10 <0.06
 
 
 

T40
Regular Member


Date Joined Oct 2009
Total Posts : 103
   Posted 8/1/2010 12:17 PM (GMT -6)   
That is statistically very significant. Now I wonder if just dropping your cholesterol by diet rather then drugs would have the same effect. It certainly justifies some who contend that diet makes a difference.
Age 40
Pre-op PSA was 5.8 from wellness test on May 19, 09
Follow up test from uro was 4.6 with a 9.3% free psa
Gleason 3+3 in one core, 3+4 in second core of 12 samples taken
Surgery performed August 19th, 09.
One side nerves spared. Nerve graft on other side.
Six weeks incontinence almost over. ED a work in progress but seeing some response.
4 months no longer using pads. ED using trimix with positive response.
Post op October 2nd, 2009 All margins were negative. PSA results in a few days.
Post op pathology 3+4 PT2A NOMO
6 wk PSA .004
3 month PSA .003 12-18-09
6 month PSA .003 3-17-10

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7213
   Posted 8/1/2010 2:13 PM (GMT -6)   
That's interesting, because I've just restarted a statin (zocor)!
 
Mel

63 years old . PSA-- 3/08--2.90; 8/09--4.01; 11/09--4.19 (Free PSA 24%),  after 45 days on cipro! DREs have always been normal. PCA-3 was about 75 (way above the 35 threshold). That led to:

Biopsy on 11/30/09. 5 out of 12 cores positive. Gleason 4+3. 2 cores were 3+3 (one 5% and the other 30%) on one side. On  other side:2 cores are 4+3 (5%)--1 core 3+4 (30%) no peri-neural invasion. prostate is 45 grams. Stage: T1C.  

Surgery with Dr. Menon at Ford Hospital, 1/26/10. He says all looked good. Spared nerves. Unfortunately: Pathology Report: G 4+3 (65%-35%). Cancer in 15% of gland. Lymph Nodes: Clear.  Perineural Invasion: yes. Seminal Vessical Involvement: No.  Extraprostatic Extension: yes.  Positive Margin: Yes-- focal-- 1 spot .5mm. Final Weight is 52.7 gms.  (Second opinion from Jon Epstein at Hopkins confirmed these results)

 Incontinence: joined that club-- definite leaks—1 pad/day. Night is dry, was  using 1 pad at night for security, but pretty much dispensed with that most nights. Update: no pads at night. No pads while at home, but still very uncomfortable. Use 1 pad for out-of-house activities. Suddenly got MUCH better on 3/10/10, almost overnight. Still some urgency but no pads about 90% of the time.  As of 3/12/10--completely continent! Uh...OH. As of about 3/16/10 problems with constant urgency although no pads needed--feels like an infection but none showing in urine.

Update: since late March all is well in that area. I would say 99.9% continent (a spurt here and there, maybe 5 spurts per week). As of 6/22/10, I would say I am 100% continent, but I do have (controllable) significant urgency.

First post-op PSA on 3/10/10--DRUM ROLL: 0.01 Next PSA in mid-June.

Second post-op PSA on 6/21/10--0.02--Not too bad!


Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 8/1/2010 2:56 PM (GMT -6)   
A Mayo clinic study also showed similar results.  Another study (can't find it now) stated that the statins provided the cancer benefit rather than the lower cholesterol.  This is what Mayo clinic: http://www.mayoclinic.org/news2009-rst/5252.html  had to say.
 
"In the first study, researchers followed the 2,447 men for over 15 years and discovered that men taking statins were less likely to develop prostate cancer, compared to men who did not take statins.

Of the statin users, 38 (6 percent) were diagnosed with prostate cancer. Comparatively, non-statin users were three times more likely to develop prostate cancer, suggesting statin use may prevent development of prostate cancer."

Good news if one is already using statins.

Carlos


Diagnosed 2/2008 at age 71, Gleason score 5+3, stage T1c, PSA 9.1. 
Robotic surgery 5/2008, nerves spared, stg. pT2c, N0, MX, R0, Gleason 5+3 
PSA <0.1 at 26 months and at all tests since surgery.

compiler
Veteran Member


Date Joined Nov 2009
Total Posts : 7213
   Posted 8/1/2010 3:48 PM (GMT -6)   
But for those of us who have already joined this club that nobody wants to join, will statins help prevent reoccurrence?
 
Mel

63 years old . PSA-- 3/08--2.90; 8/09--4.01; 11/09--4.19 (Free PSA 24%),  after 45 days on cipro! DREs have always been normal. PCA-3 was about 75 (way above the 35 threshold). That led to:

Biopsy on 11/30/09. 5 out of 12 cores positive. Gleason 4+3. 2 cores were 3+3 (one 5% and the other 30%) on one side. On  other side:2 cores are 4+3 (5%)--1 core 3+4 (30%) no peri-neural invasion. prostate is 45 grams. Stage: T1C.  

Surgery with Dr. Menon at Ford Hospital, 1/26/10. He says all looked good. Spared nerves. Unfortunately: Pathology Report: G 4+3 (65%-35%). Cancer in 15% of gland. Lymph Nodes: Clear.  Perineural Invasion: yes. Seminal Vessical Involvement: No.  Extraprostatic Extension: yes.  Positive Margin: Yes-- focal-- 1 spot .5mm. Final Weight is 52.7 gms.  (Second opinion from Jon Epstein at Hopkins confirmed these results)

 Incontinence: joined that club-- definite leaks—1 pad/day. Night is dry, was  using 1 pad at night for security, but pretty much dispensed with that most nights. Update: no pads at night. No pads while at home, but still very uncomfortable. Use 1 pad for out-of-house activities. Suddenly got MUCH better on 3/10/10, almost overnight. Still some urgency but no pads about 90% of the time.  As of 3/12/10--completely continent! Uh...OH. As of about 3/16/10 problems with constant urgency although no pads needed--feels like an infection but none showing in urine.

Update: since late March all is well in that area. I would say 99.9% continent (a spurt here and there, maybe 5 spurts per week). As of 6/22/10, I would say I am 100% continent, but I do have (controllable) significant urgency.

First post-op PSA on 3/10/10--DRUM ROLL: 0.01 Next PSA in mid-June.

Second post-op PSA on 6/21/10--0.02--Not too bad!


mvesr
Veteran Member


Date Joined Apr 2007
Total Posts : 823
   Posted 8/1/2010 6:27 PM (GMT -6)   
Dear RCS

I guess there is an added benefit for trying to swallow those horse pills.

Mika
age at dx 54 now 58
psa at dx 4.3
got the bad news 1/29/07
open surgery Duke Medical Center 5-29-07
never more than 2 pads
ED is getting better
the shots work great, still can't give them to myself
three years of zero's
Retired again after 36 years February 1, 2010

Carlos
Regular Member


Date Joined Nov 2009
Total Posts : 486
   Posted 8/1/2010 6:54 PM (GMT -6)   
Compiler,  The study RCS mentioned sounds like the Duke study at this link: http://www.webmd.com/prostate-cancer/news/20100628/statins-may-protect-prostate-cancer-patients.  "The research does not prove that taking cholesterol-lowering drugs directly slows the growth and progression of prostate cancer. But the fact that the fewest recurrences were seen in men who took the highest statin doses is compelling, says senior investigator Stephen J. Freedland, MD, of the Duke Prostate Center."
 
Carlos

Diagnosed 2/2008 at age 71, Gleason score 5+3, stage T1c, PSA 9.1. 
Robotic surgery 5/2008, nerves spared, stg. pT2c, N0, MX, R0, Gleason 5+3 
PSA <0.1 at 26 months and at all tests since surgery.

medved
Veteran Member


Date Joined Nov 2009
Total Posts : 1096
   Posted 8/1/2010 7:50 PM (GMT -6)   
<<Another study (can't find it now) stated that the statins provided the cancer benefit rather than the lower cholesterol. >>
 
Carlos - I would be very interested in this study if you can find it. I have looked for such evidence previously but have not found it.  My question, every time I see one of these "statin" studies, is whether the benefit is from taking statins or from having low cholesterol. 
 
For example, it would be interesting to compare the incidence of prostate cancer (or prostate cancer recurrence) among two groups:  those who have total cholesterol of 130-140 without taking statins, and those who have total cholesterol of 130-140 with statins.  Or some varation of that...
 
 
Age 46.  Father died of p ca. 
My psa starting age 40: 1.4, 1.3, 1.43, 1.74, 1.7, 1.5, 1.5
 

Old Sailor
Regular Member


Date Joined Aug 2009
Total Posts : 208
   Posted 8/1/2010 8:24 PM (GMT -6)   
Hate to put a damper on good news but I have been on statins for over 10 years and my LDL has been under 70 for years.  I had gleason 9 and short recurrence after RRP with SRT completed in June.  Go figure??? The Old Sailor   
Dx 07/09 Age 67  -  28 core saturation biopsy w/5 positive  (2 gleason 8, 2 gleason 7, 1 gleason 6)
RRP 8/13/09 Mayo Clinic Jacksonville
Path report upgraded gleason to 4+5=9
Negative margins/extraprostatic extension/seminal vessicles/ lymph nodes but perineural invasion present.
Two month post surgery PSA 0.022
Five month post surgery PSA  0.081
Seven month post surgery PSA 0.190
Eight month post surgery PSA 0.217
Started 38 sessions IMRT at Mayo Jacksonville on 4/12/10,  completed 6/4/10.  Few side effects except urinary urgency and  frequency during the day and some rectal discomfort near the end of therapy. 

BB_Fan
Veteran Member


Date Joined Jan 2010
Total Posts : 1011
   Posted 8/1/2010 9:09 PM (GMT -6)   
Ditto to old sailer. I have been on statins for over 10 years abd I had a gleason 8 with a recurence of PCa 1 year after surgery. Again, go figure.
Dx with PC Dec 2008 at 56, PSA 3.4


Biopsy: T1c, Geason 7 (3+4) - 8 cores taken with 4 positive for PCa, 30% of all 4 cores.

Robotic Surgery March 2009 Hartford Hospital, Dr Wagner
Pathology Report: T2c, Geason 8, organ confined, negitive margins, lymph nodes negitive - tumor volume 9%
nerves spared, no negitive side effects of surgery

One night in hospital, back to work in 3 weeks

psa Jun 09 <.01
psa Oct 09 <.01
psa Jan 10 .07 re-test one week later .05
psa Mar 10 .28 re-test two weeks later .31
psa May 10 .50

April 10 MRI and Bone Scan show lesion on lower spine, false positive.

Started HT 5/25/10 with 3 month shot of Trelstar. SRT scheduled for late July

psa July 10 <.01 HT at work

RCS
Veteran Member


Date Joined Dec 2009
Total Posts : 1247
   Posted 8/2/2010 6:00 AM (GMT -6)   
Old Sailor and BB Fan,
 
Yeah, each time I think I've figured something out on PCa, I find opposing data. 
 
Best wishes on treating your recurrences.
PSA 2007 - 2.8
PSA 11/24/2008 - 7.6
Pc Dx 2/11/09; age at Dx 62
RLP 4/20/09
Biopsy -  Invasive moderately differentiated prostatic andenocarconoma; G 3+3=6; PT2C; No evidence of Seminal Vesicle or Extraprostatic Involvement; Margins clear; Tumor identified in sections from prostatic apex.
70 gram prostate.
Immediately continent after removal of cath.
ED - Trimix works well; viagra @ 70%
PSA - 7/31/09 <0.06
PSA - 12/1/09 <0.06
PSA - 3/29/10 <0.06
 
 
 
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