Thalidomide, revlamid, ...,
I know my list is not complete too, feel free to find other drugs used and mention them. Is this an arsenal or what? Surely our local uro-doc would know how to use all these???(LOL)
I saw an interesting article www.jurology.com/article/S0022-5347%2808%2903053-X/abstract
where hormone therapy was combined
with thalidomide in an intermittent treatment: on-period 6 months HT, then stop, and off-period with thalidomide. The off-period became 2.6 times longer !!
This is exactly the way Leibowitz's protocol works, but then with a (combi-) chemo therapy: 4 months chemo's, then stop, continue for 1 to 2 years (!) with (a combi-) thalidomide+Revlimid.
But he claims that in the following cycles: a) the on-period will be still 4 months, b) the off-period will be still as long as in the previous cycles. What he calls: 'Succesfully live with Advanced Prostate Cancer'.
Lenalidomide (brandname Revlimid) has been called the '2nd-generation thalidomide'.
The Casodex is not working for me anymore, so I am now asking for thalidomide, which was sold over the counter from 1957 to 1961 as a sedative drug and sleeping pil, but forbidden since then because of severe birth defects when used by pregnant women. You now need an exemption to be allowed to use it.
The advantage of combination therapies is that combinations of drugs can be found that:
a) enhance the response rate, e.g. with mono-therapies having 60%, a combi of 2 might have 80%, a combi of 3 have 90%, and even a combi of 4 has been found which had close to 100% response.
b) the reduction of PSA can be much stronger for the combi's. For example, the combi of 4 chemo's had a PSA reduction of 99.3%, on average.
c) Because the drugs enhance each others efficacies, you can lower
the doses. And that makes all the difference when it comes to side-effects.
Leibowitz uses also a combination of anti-angiogenics, such as thalidomide, lenalidomide (brandname Revlimid) and bevacizumab (brandname Avastin).
And although numerous phase I and II trials of combination therapies have been done from 1994 until today, e.g. jco.ascopubs.org/cgi/content/abstract/28/12/2070
when you ask for it, none of it is available to us. The only thing offered is to join yet an other trial, with 50% chance of getting a placebo.
When the results of 16 years of research in the industry had not reached the market then it certainly would have not continued that long. How is it possible that research oncologists can go on with these randomized, double-blinded studies for ever without ever delivering anything to us, PC patients ??
March'06: PSA 3.6
Diagnosed at age 63 Sep'09: PSA 575, GS 7 (4+3)
3 positive cores in 6
Bone scan: as a fully lit christmas tree
With Zoladex+150mg Casodex PSA <0.1
Additionally 4-weekly Zometa (zoledronin acid)
Post Edited (Arno) : 8/9/2010 2:32:16 AM (GMT-6)