Lupron vs. Degarelix

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dkob131
Regular Member


Date Joined Apr 2008
Total Posts : 364
   Posted 8/8/2010 11:13 AM (GMT -6)   
Because of the interest recently in Lupron, here's a study comparing it to the new drug Degarelix.  It gives all of the information related to "lupron flare" and how long lupron takes to send your PSA to its nadir.  The study also shows the same thing for Degarelix. 
 
 
David
54 y.o.
Diagnosed 4/10/08

DRE Normal

PSA-5.5

Biopsy- 12 cores, 4 positive highest 4+4=8

Bone scan, CT scan and Chest X-ray clear 4/16/08

Urologist suggested surgery 4/16/08

MRI on 4/24/08 clear no suggestion of lymph node involvement.

4/24/08 -Started on Lupron and Casodex preparing for HDRT and IMRT in late July. This treatment will not preclude me from surgery if I change my mind.

Decide to have DaVinci surgery after another consult with surgeon.

6/19/08- DaVinci surgery at University of Washington.

6/25/08- Path report, clear margins, no noted extension

9/12/08- PSA <0.02

12/05/08-PSA <0.02 Six months after surgery

3/02/09-PSA <0.02 Nine months after surgery

5/02/09-PSA .10

8/17/09-PSA .21 Begin HT and set up for SRT to begin in 2 months.

12/31/09- SRT completed, still on HT and will be for 2 years, PSA is <0.01

7/30/10- PSA still <0.01, on HT 1 year with 1 to go.

dkob131
Regular Member


Date Joined Apr 2008
Total Posts : 364
   Posted 8/8/2010 11:34 AM (GMT -6)   
The link appears to be broken, is anyone able to bring the study up.
 
David
 
54 y.o.
Diagnosed 4/10/08

DRE Normal

PSA-5.5

Biopsy- 12 cores, 4 positive highest 4+4=8

Bone scan, CT scan and Chest X-ray clear 4/16/08

Urologist suggested surgery 4/16/08

MRI on 4/24/08 clear no suggestion of lymph node involvement.

4/24/08 -Started on Lupron and Casodex preparing for HDRT and IMRT in late July. This treatment will not preclude me from surgery if I change my mind.

Decide to have DaVinci surgery after another consult with surgeon.

6/19/08- DaVinci surgery at University of Washington.

6/25/08- Path report, clear margins, no noted extension

9/12/08- PSA <0.02

12/05/08-PSA <0.02 Six months after surgery

3/02/09-PSA <0.02 Nine months after surgery

5/02/09-PSA .10

8/17/09-PSA .21 Begin HT and set up for SRT to begin in 2 months.

12/31/09- SRT completed, still on HT and will be for 2 years, PSA is <0.01

7/30/10- PSA still <0.01, on HT 1 year with 1 to go.

medved
Veteran Member


Date Joined Nov 2009
Total Posts : 1096
   Posted 8/8/2010 11:56 AM (GMT -6)   
I dont have that study, but if you are considering Degarelix, you might be interested in looking at the "full prescribing information" which you can get by clicking on this link and then clicking, to the right, on "full prescribing information."

http://www.firmagon.us/us/us-hcp1sub1/pcl-contentsh/accessser/0/257/211/what-is-firmagon.html

Table 1 compares adverse events from Degarelix (trade name: firmagon), in two doses, compared to Lupron.

You can also get more Phase 3 study data from this link.
Age 46.  Father died of p ca. 
My psa starting age 40: 1.4, 1.3, 1.43, 1.74, 1.7, 1.5, 1.5
 
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