PSA still going up after surg and radiation

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Bob & Wife
Regular Member

Date Joined Apr 2008
Total Posts : 100
   Posted 8/13/2010 8:09 PM (GMT -6)   
Got the call this afternoon from my doctors nurse and my psa is still going up despite surgery and radiation. Would have been two years post radiation the 18th of this month. It is now .19 up from .14 8 weeks ago. Waiting to hear from the doctor tonight. Guess the radiation didn't work. Wife and I have had anxiety all day waiting to hear probably because we knew it was going to be up again. shakehead Bob
Age at diagnosis 58
PSA 1.7 Nodule felt. Biopsy 4+4 T2
1-30-06 Surgery nodes & margins clear, some prostrate cells found on bladder neck. 4+3 after surgery
12-07 PSA jump .14 (11 Months)
12-07 Nodule felt biopsy negative
PSA .16
PSA .17
4-3-08 PSA .32
4-15-08 Nodule size increased
5-8-08 PSA still .32
5-30-08 Biopsy of nodule positive. Next step consultation with oncology 6-5-08 for further scans & test
8-14-08 Completed Tomotherapy
12-18-08 Post Radiation PSA .05
3-27-09 3rd Post Radiation PSA .06
7-17-09 4th Post Radiation PSA .05
12-09 Post PSA.06
3-19 psa .18
3-25 psa .08
6-1-10 psa .14 Next PSA 8-1-10

Veteran Member

Date Joined Jan 2010
Total Posts : 2845
   Posted 8/13/2010 8:21 PM (GMT -6)   
bob - so sorry to read your numbers are up again - they seem to bounce up and down - here's to an informed resolve from the doctor(s) to get those numbers back down and steady again.
-wishing you and your wife all the best.
Age: 54 -gay with spouse, Steve - live in Peteborough, Ontario, Canada
PSA: 10/06/2009 - 3.86
Biopsy: 10/16/2009- 6 of 12 cancerous samples, Gleason 7 (4+3)
Radical Prostatectomy: 11/18/2009
Pathology: pT3a- gleason 7 -extraprostatic extension -perineural invasion -prostate weight -34.1 gm
Post Surgery-PSA: April 8, 2010 - 0.05 -I am in the ZERO CLUB - hooorah!
Next PSA: October 8, 2010 -TBA

Cajun Jeff
Veteran Member

Date Joined Mar 2009
Total Posts : 4119
   Posted 8/13/2010 8:29 PM (GMT -6)   
Bob,  Im so sorry to hear that the numbers are still climbing ever so slow but still clumbing.  I do hope that you Dr. got in touch with you this afternoon to give you some thoughts on what the next step should be.  Do not dispair there are other things to do. 
Know that we are in the corner with you and your wife where.  Do keep us posted. 
Cajun jeff
9/08 PSA 5.4 referred to Urologist
9/08 Biopsy: GS 3+4=7 1 positive core in 12 1 pre cancer core
10/08 Nerve-Sparing open radical
Surgery Path Report Downgrade 3+3=6 GS Stage pT2c margins clear

3 month: PSA <0.1
6 month: PSA <0.1
10 month:PSA <0.1
1 year: PSA <0.1
16 month:PSA <0.1

ED - Started Cialis at 3 months, tried all 3, 6 months added pump, 9 months Tried MUSE (YUCK) Bad experience.
1 year mark Found new Urologist visit was at 14th month post surgery
Started Injections, Caverject! (Success)
17 month: ED making improvements : Oral Meds gets me 85%

Willie B
Regular Member

Date Joined Jul 2010
Total Posts : 155
   Posted 8/13/2010 8:52 PM (GMT -6)   

So very sorry to hear that your numbers are going up.

I hope your doctor had a plan for you tonight, there are other things that can sometimes be used.

Regular Member

Date Joined Mar 2007
Total Posts : 448
   Posted 8/13/2010 9:48 PM (GMT -6)   
So sorry to hear that your numbers have crept back up...    Hopefully,  your doc will have a plan for you to bring these numbers back in line...
I would be interested in your Tomotherapy...   how many treatments and the total dose if you do noy mind...
Take Care Bob...   Will keep you in my prayers if that is alright with you...
God Bless,
After 3-4 years of annual PSA 4-6, biopsy recommended
59 y/o
3/13/2007 - 12 point biopsy - Left 0/6 Right 1/6 Gleason 3+3 T1c
4/24/2007 - DaVinci performed at Virginia Mason hospital in Seattle
5/2/2007 - Catheter Out! Final pathology of Gleason 6 T2c Nx Mx, approx 20% of prostate involved, positive margin, but only at 2 focal points.
6/28/2007 9 weeks incontinance... Overnite, went from 4-6 soaked pads a day from prev 8 weeks to 2 barely wet pads a day.
7/12/2007 11 weeks post-op Minimal leakage... one small pad a day
7/18/2007 First Post-Op PSA... 0.01 !!!
9/10/2007 Pad free and ED at 75% with 100mg Viagra generic
6/26/2008 2nd Post-OP PSA at 14 months... 0.02
12/2/2008 3rd Post-OP PSA at 20 months... 0.03
10/30/2009 4th Post-OP PSA at 31 months... 0.13 (moved and diff lab)
11/3/2009 Retest at my original lab... 0.11 (followup with Doc sched 11/10)
11/10/2009 Discussion indicated biochemical reccurrence and need for salvage radiation treatment.
1/21/2010 Another PSA test at 34 months... 0.14
1/26/2010 IMRT Salvage Radiation Treatment started
32 sessions for 64 gys total.
3/12/2010 Finished 32 sessions... No side effects to date except a little
tiredness. Slight changes in bowel movements the last week...
4/8/2010 Some rectal prostitis, but no change in urgency. No urinary effects at all. Now just waiting for the upcoming PSA test in June.
6/7/2010 First 3 month PSA result after SRT = 0.02 WAHOO! as good as could ever be expected at the 3 month mark! Thank You Jesus!

Veteran Member

Date Joined May 2009
Total Posts : 2692
   Posted 8/13/2010 9:59 PM (GMT -6)   

This is a turn in the road, not a dead end. As I am sure you have read here on HW, we have men who have been going for many years with numbers worse than yours.

I am glad your doctor is on top of it. But don't be afraid to seek multiple opinions about the next step. The thread by Sonny has some great info and advice.

Good luck to you and your wife. You are not alone in this.
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared, but carved up a little.
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks .
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)
5 month PSA <.03 (undetectable)
6 Month PSA <.01
1 pad a day, no progress on ED.  Trimix injection
No pads, 1/1/10,  9 month PSA < .01
1 year psa (364 days) .01
15 month PSA <.01

Veteran Member

Date Joined Jul 2010
Total Posts : 3892
   Posted 8/14/2010 12:48 PM (GMT -6)   
Walsh's "Guide to Surviving Prostate Cancer, second edition, (2007) pages 390-394..

Worth reading and you might find some comfort here..
Age today: 68. Married, 6', 215 pounds, active, no health issues.
PSA at age 55: 3.5, DRE negative. Advice, "Keep an eye on it".
PSA at age 58: 4.5
PSA at age 61: 5.2
PSA at age 64: 7.5, DRE "Abnormal"
PSA at age 65: 8.5, DRE " normal", biopsy, 12 core, negative...
PSA at age 66 9.0 DRE "normal", BPH, Finesteride. (Proscar)
PSA at age 67 4.5 DRE "normal" second biopsy, negative.
PSA at age 67.5 5.6, DRE "normal" U-doc worried..
PSA at age 68, 7.0, third 12 core biopsy positive for cancer in 4 cores, 3 cores Gleason 6, one core Gleason 9. Finesteride discontinued, still no urinary symptoms, never had any..From age 55 to 65 I had no health insurance.

I have a date with the robo surgeon on Sept 3 but I'm keeping my options open. I'm also looking at seeds combined with IGRT which seems to be having good results with high-risk patients..
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