Hi Jim, Hi bsjoplin
It seems that you are anxious to see where yours PSA levels go. It happened to me too in 2007. However, the PSA in our cases (post-SRT after RP, without HT) act differently and not as linear as we think. Some guys get to very small numbers <0.03 and some at higher levels of 1.50 ng/ml or more. In cases where the prostate gland is still present, some guys experience a bounce that may last for several months, before it goes down to its real nadir level.
The importance is not the number but what it is considered as each one’s Nadir PSA (nPSA=0.0). In my case, the Nadir PSA is 0.26 ng/ml (nPSA=0.0). It sounds confusing, but Specialists from SMKCC in resent researches (2006), recommend the use of the third rise in PSA after its lowest level, (corresponding to PSA=0.0), to serve as the basis for future prognosis of the PC. My lowest was 0.05, and the third rise was: 0.12; 0.18; 0.26 (reached on the 29th month after SRT).
Because of the discrepancies in the values of PSA among patient, back in 2000, Oncologists got into a consensus that Biochemical recurrence (failed RT) was verified once the PSA has risen three times from its lowest level. Accordingly, each case would have different numbers and different periods from SRT to nadir PSA.
I hope that your Nadirs get as low as possible and that it keeps down there for a very long time, with no “third” rise.
Wishing you the best,
Age: 50 at Dx on May/2000; PSA=22.4;
Asymptomatic; Negative DRE and MRI & Bone scan
6x cores biopsy positive; Gleason (2+3)=5
RP surgery performed Aug/2000 Dr Komatsu, Toranomon, Tokyo
Voluminous tumor; seminal vesicles & pelvic lymph nodes (9) negative; capsular penetration
Adenocarcinoma, well-differentiated; pT3apN0
Post-op lowest PSA=0.18 on Oct/2000;
Mar/2001 PSA=0.42 Biochemical Failure; Classified as Micro Metastasis
Watchful Waiting until PSA=3.55 on Sep/2005 (doubling average of14 months)
Nov/2006 SRT (3D IMRT; 68Gy in 37 fractions) Dr G. Vieira, CRMN, Portugal
Post RT PSA=2.28 on Jan/2007
Feb/2008 lowest nPSA=0.05
Aug/2008 MRI negative to metastasis
May/2009 Biochemical recurrence PSA=0.26
Aug/2010 PSA=0.79 (doubling time of 8 months)
Ten years Asymptomatic ; never incontinent
ED since RP; Anorectic symptoms during first year after SRT