First PSA 1 Month After Radiation

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howard l
Regular Member

Date Joined Aug 2010
Total Posts : 152
   Posted 9/1/2010 3:50 PM (GMT -6)   
I just received my first PSA 1 month post radiation. It has droped from 1.5 to .47. I know they say it really takes 3 months to see the full benefit from the radiation. My questions are should I wait the full 3 months or should I start ADT now and is this drop a significant one.
DX age 58
PSA 5.4
Gleason 5+4 = 9
City of Hope Clinical Trial (punch protocol). 6 sessions textore every 3 weeks + lupron
PSA .1
RP Oct 2009. Seminal Invasion positive margins. Lymphnods clear.
1 month PSA post op undetectable.
4 month PSA undetectable.
7 month PSA .5
Bone scan and CT scan negative. Prosticint scan mild activity in prostate bed.
EBRT May 2010. 39 sessions 70gy. On number 37.

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 9/1/2010 4:23 PM (GMT -6)   
If it were me I would have started ADT before radiation...In fact that's what I did...

I also started ADT before my PSA rose after RP had similar numbers to yours. I am familiar with the Taxotere trial. it was not out when I started out though I'm not sure I would have joined it. I did take a look at the Sanofi-aventis trial for after surgery left me at T3b. But they would not have allowed radiation in that study. I opted out, but followed most of the study. Surgery, ADT, radiation in that order.

Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog :

Veteran Member

Date Joined May 2009
Total Posts : 2692
   Posted 9/1/2010 5:25 PM (GMT -6)   
Can't say I know much about it, but I would say the radiation is working well. Sounds like it hit the bullseye.

If I were you, (and I am not), I would give my body a little rest and see what happens. I have not seen any studies that say that beginning ADT sooner or later is significant in effectiveness.

But that is why you have experienced and professional doctors advising you.

Good luck, and conbgrats on the early success.
Age 58, PSA 4.47 Biopsy - 2/12 cores , Gleason 4 + 5 = 9
Da Vinci, Cleveland Clinic  4/14/09   Nerves spared, but carved up a little.
0/23 lymph nodes involved  pT3a NO MX
Catheter and 2 stints in ureters for 2 weeks .
Neg Margins, bladder neck negative
Living the Good Life, cancer free  6 week PSA  <.03
3 month PSA <.01 (different lab)
5 month PSA <.03 (undetectable)
6 Month PSA <.01
1 pad a day, no progress on ED.  Trimix injection
No pads, 1/1/10,  9 month PSA < .01
1 year psa (364 days) .01
15 month PSA <.01

Veteran Member

Date Joined Jan 2009
Total Posts : 2243
   Posted 9/1/2010 5:58 PM (GMT -6)   
Sounds like some of our stats were alike, but gleason 8 here. I dint have the Lupron so really cant answer your question in a wise manner, but you had a good drop in your PSA. Best to you and keep us posted.
Dx with PCA 12/08 2 out of 12 cores positive 4.5 psa
59 yo when diagnosed, 61 yo 2010
Robotic surgery 5/09 Atlanta, Ga
Catheter out after 10 days
Gleason upgraded to 3+5, volume less than 10%
2 pads per day, 1 depends but getting better,
 started ED tx 7/17, slow go
Post op dx of neuropathy
T2C left lateral and left posterior margins involved
3 months psa.01, 6 month psa.4, 6 1/2 month psa.5 on 11/28/10
Starting IMRT on 1/18/10, Completed 39 tx at 70 gys on 3/12/10
6 week Post IMRT PSA .44 a drop from .5 but maybe more
Great family and friends
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