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Regular Member

Date Joined Feb 2007
Total Posts : 122
   Posted 9/12/2010 8:20 AM (GMT -6)   
how long after your first lupron shot do the side effects start

Veteran Member

Date Joined Jan 2010
Total Posts : 1011
   Posted 9/12/2010 8:54 AM (GMT -6)   
for me it took about two weeks for the ED to really kick-in. hot flashes started sooner. perhaps after a few days. didn't really have any other issues.
Dx with PC Dec 2008 at 56, PSA 3.4

Biopsy: T1c, Geason 7 (3+4) - 8 cores taken with 4 positive for PCa, 30% of all 4 cores.

Robotic Surgery March 2009 Hartford Hospital, Dr Wagner
Pathology Report: T2c, Geason 8, organ confined, negitive margins, lymph nodes negitive - tumor volume 9%
nerves spared, no negitive side effects of surgery

One night in hospital, back to work in 3 weeks

psa Jun 09 <.01
psa Oct 09 <.01
psa Jan 10 .07 re-test one week later .05
psa Mar 10 .28 re-test two weeks later .31
psa May 10 .50

April 10 MRI and Bone Scan show lesion on lower spine, false positive.

Started HT 5/25/10 with 3 month shot of Trelstar. SRT scheduled for late July

psa July 10 <.01 HT at work

Veteran Member

Date Joined May 2008
Total Posts : 1010
   Posted 9/12/2010 10:16 AM (GMT -6)   
Hi Mgl,
I recently completed a two year regimen of Lupron. Here is how it went.
Nothing for the first two weeks. Then hot flashes. These seemed to be worse (intensity and frequency) for the first shot. Seemed to diminish over time. Either that or I learned to live with it. Still have some early morning and late night and it has been nine months since my last shot.
Loss of libido by the fourth week. Still has not come back.
Lost body hair gradually over three or four month period. Looks like some of it is coming back but not much. Mostly on legs, chest and arms. Not that hairy to begin with but made it look like I shaved my legs. smilewinkgrin
ED within the first month. Erectile function has not returned although I get some minor stiffining. Do not know if this is the HT or the radiation. I do not use ED meds. No partner so no problem.
Here is one most do not speak of.... testicles shrunk. Seem to be recovering a bit now.
Energy level. Drooped a little but a regular exercise routine kept that at bay. The last shot seemed to be the worst for this. I figured it was a cumulative effect.
Never got any swelling in the breast area. (I was, oddly enough, very concerned about this one.)
Gained about 20 pounds the second year. Just could not keep it off. Working it off now that I am off the Lupron for a bit.
Finally, none of these SE's impacted my quality of life significantly. I continued and still continue to do all the things I enjoy.
Best of luck to you.
Diagnosed 04/10/08 Age 58
Gleason 4 + 3
DRE palpable tumor on left side
100% of 12 cores positive for PCa range 35% to 85%
Bone scan and chest x ray clear
CT scan shows potential lymph node involvement in pelvic region
IGRT/IMRT with adjuvant HT (lupron) 2yrs
02/08 21.5
07/08 0.82
10/08 .642
09/09 0.32
03/10 0.32
06/10 0.32
07/10 0.10

Veteran Member

Date Joined Feb 2010
Total Posts : 3998
   Posted 9/12/2010 10:47 AM (GMT -6)   

i began a sub-clinical dose of celexa before my first shot of lupron to prevent hot flashes and it worked. i do get some flashes but they are muted. the heat really affects me adversely though.  i also never got the breast tenderness.  i did gain 20 pounds.

i've been on lupron for the past six months but during that time i've also had brachy therapy and 28 IGRT sessions so it's hard for me to tell which side affects are just from the lupron.  the worst side affects  coincided with brachy therapy.


age: 55
PSA on 12/09: 6.8
no symptoms, no prostate enlargement
12/12 cores positive....gleason 3+4 = 7
ADT, brachy and IGRT

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 9/12/2010 3:48 PM (GMT -6)   
I took me almost a month to get the true HT side effects. And I didn't have any urges to go shoe shopping for most of the first shot. That came later then I out shopped my wife...

Seriously, my experience was like Don's. Juts delayed a little bit more. It is highly possible that since my first shot was near the end of may, but the time it kicked in so did summer here in Las Vegas. Everybody has hot flashes here in the summer.

Mike, it's good to see you again. I hope all else is well for you. You can handle the HT. I did and after your PSA drops out, you can stop and everything comes back.

Peace and prayers for you, buddy...,

Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog :

Regular Member

Date Joined Jul 2010
Total Posts : 32
   Posted 9/12/2010 5:26 PM (GMT -6)   
Woody is into 9th week on Lupron.  Hot flashes are frequent, sometimes 2-3 an hour during the day.  He has not experienced any issues with ED (I'm worried about this and have been asking him to get testerone checked) although his libido has decreased significantly.  Still, when he remembers that its been 4-5 days since - he is fully capable on his own power.  Also he has been having almost constant headaches.  Saw his primary care dr. on friday who put him high blood pressure meds.  Did not have high blood pressure before treatment began but don't know if this is related.
Woodys stats:
Age at daignosis 55
4/2010 PSA 26.5
Biopsy results 4 of 6 positive at 40% R&L mid; 60% L apex; 80% R apex - perineural involvement
Gleason 7 (3+4 in 3 and 4+3 at R apex)
Treatment choice: ADT/EBRT/HDR
First Lupron shot July 2010, 5 weeks radiation to begin in sep followed by 2 HDR treatments
Woodys father died of PC at age 55 (woody was 5yo), we did not know until after diagnosis

Veteran Member

Date Joined Dec 2008
Total Posts : 3149
   Posted 9/12/2010 6:53 PM (GMT -6)   
I cannot say if the Lupron is the cause of the headaches, but high blood pressure and constant headaches are both not great things to be also dealing with. Google or search more on constant headaches, it surprized me as to actually how severe it could be depending upon the under lying causes. High blood pressure can be very worrisome too. The ED will likely be coming soon enough, the weight gain is also in the mix, but those are things we have to put up with in so using it. You might wish to get a second opinion on these events, just a thought.
Dx-2002 total urinary blockage, bPsa 46.6 12/12 biopsies all loaded 75-95% vol.; Gleasons scores 7,8,9's (2-sets), gland size 35 normal, ct and bone scans appearing clear- ADT3 5 months prior to radiations neutron/photon 2-machines, cont'd. ADT3, quit after 2 yrs. switched to DES 1-mg, off for 1 yr., controlled so well, resumed, using intermittently, pleased with results
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