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New Member

Date Joined Sep 2010
Total Posts : 1
   Posted 9/15/2010 7:40 PM (GMT -6)   
Greetings - I have just returned from my urologist appointment where I was told that my latest biopsy was negative, however, the two pathology reports were conflicting.  I was treated in early 2009 with HDR radiation.  PSA level dropped to .7 at May 2010, however has increased from .7 in May to 1.6 in June, 2.5 in July and 3.6 in August, new biopsy with results as indicated above.  My concern is that this may not just be a bounce - any thoughts from any one would be appreciated. 

Veteran Member

Date Joined Apr 2008
Total Posts : 1382
   Posted 9/15/2010 8:48 PM (GMT -6)   
I have a friend that is 50 years old and has experienced a similar story, his PSA has gotten as high as 6.5 and finally his urologist ordered a saturation biopsy of which come back negative. So it is common and yes highly possible to have an elevated PSA and not have cancer. I would encourage you to find a way to put your mind at ease.

peace to you
My PSA at diagnosis was 16.3
age 47 (current)

My gleason score from prostate was 4+5=9 and from the lymph nodes (3 positive) was 4+4=8
I had 44 IMRT's
I was on Lupron, Casodex, and Avodart for two years with my last shot March 2009. I am currently (7-22-2010) not on any medication.
My Oncology hospital is The Cancer Treatment Center of America in Zion IL
PSA July of 2007 was 16.4
PSA May of 2008 was.11
PSA July 24th, 2008 is 0.04
PSA Dec 16th, 2008 is .016
PSA Mar 30th, 2009 is .02
PSA July 28th 2009 is .01
PSA OCt 15th 2009 is .11
PSA Jan 15th 2010 is .13
PSA April 16th of 2010 is .16
PSA July 22nd of 2010 is .71
Testosterone keeps rising, the current number is 156, up from 57 in May

T level dropped to 37 Mar 30th, 2009
cancer in 4 of 6 cores

Veteran Member

Date Joined Mar 2010
Total Posts : 1152
   Posted 9/15/2010 8:54 PM (GMT -6)   
Hi Farmhand,

Welcome to healing well.

I have some questions relating to your post - this hopefully will clarify your situation.
Sorry, I don't understand what the HDR radiation was treating? Were you previously diagnosed with Prostate cancer?
Was the latest biopsy a follow up biopsy? And when you refer to two pathology reports conflicting which reports are these?


Elite Member

Date Joined Oct 2008
Total Posts : 25393
   Posted 9/15/2010 9:47 PM (GMT -6)   
farm, no doctors here, but from what you describe, sounds like you may have more going on than RT bounce. what did your oncologist say about these numbers? sounds like you had RT as your primary treatment, and it is possibe it has failed, but again, your doc will be your best answer. good luck, and let us know whats going on.

david in sc
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 ?
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, on Catheter #21, will be having Ileal Conduit Surgery in Sept.

Regular Member

Date Joined Nov 2009
Total Posts : 486
   Posted 9/16/2010 6:56 AM (GMT -6)   
Farmhand,  The American Urological Assoc. in their PSA Guidelines has this to say about PSA after Brachy( I'm assuming you had HDR Brachy).
"The change in PSA following interstitial prostate brachytherapy is complex. Over the first year,
the PSA level declines, then rises again in the second or third year in up to 40% of cases, only to
fall back to much lower values by year four. Although these rises (or “benign bounces”)
are generally small (<0.8 ng/mL), they can, on occasion, be as high as 10.0 ng/mL, and they may
last for 6 to 18 months. Their cause is uncertain, but they may correspond to infarction of the
prostate occurring as a late vascular effect of the radiation."
Hope this helps.

John T
Veteran Member

Date Joined Nov 2008
Total Posts : 4268
   Posted 9/16/2010 11:29 AM (GMT -6)   
From what I've read about bounces, if the monthly psa levels go up and down without a pattern it is a psa bounce. If the increase is steadily upward it is most likely a reoccurrance. A biopsy would not eliminate a reoccurrance, only confirm one. The Dattoli Center has used Color Doppler to identify local reoccurrances.

64 years old.

PSA rising for 10 years to 40, free psa 10-15. Had 5 urologists, 12 biopsies and MRIS all neg. Doctors DXed BPH and continue to get biopsies yearly. 13th biopsy positive in 10-08, 2 cores of 25, G6 less than 5%. Scheduled for surgery as recommended by Urological Oncologist.

2nd Opinion from Dr Sholtz, a Prostate Oncologist, said DX wrong, pathology shows indolant cancer, but psa history indicates large cancer or metastasis. Futher tests and Color Doppler confirmed large transition zone tumor that 13 biopsies and MRIS missed. G7, 4+3, approx 16mmX18mm.

Combidex MRI in Holland eliminated lymphnode mets. Casodex and Proscar reduced psa to 0.6 and prostate from 60mm to 32mm. Changed diet, no meat and dairy. All staging tests indicate that tumor is local and non agressive. (PAP, PCA3, MRIS, Color Doppler, Combidex, tumor reaction to diet and Casodex, and tumor location in transition zone). Surgery a poor option because tumor is located next to the urethea and positive margin is very likely; permanent incontenance is also high probability with surgery.

Seed implants on 5-19-09, 3 hours door to door, no pain, minor side affects are frequency and urgency; very controlable with Flowmax and lasted 4 weeks. Daily activities resumed day after implants with no restrictions. Gold markers implanted with seeds to guide IMRT.

25 treatments of IMRT 6 weeks after seed implants. No side affects at all.

PSA at end of treatment 0.02 mostly the result of Casodex. When I stop Casodex next week expect PSA to rise. Next PSA in November. Treatments and side affects have greatly exceeded my expectations. Glad to have this 11 year journey finally conclude.


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