Thank you Bill and Bronson,
Decided to take a chill pill and not think of PC for a little while. But I'm back now.
The accuracy of the reading is dependent on the assay used and the 3rd generation DMC test that Bill and I do is very sensitive - this may or may not be the test that other people use and therefore may not be comparable.
See Table 5 in http://www.prostate-cancer.org/education/preclin/McDermed_Using_PSA_Intelligently2.html
where the third generation DMC test provides a post-RP nadir which can be related to the probability of biochemical recurrance. For a reading of <0.01 this is 4%, for a reading of 0.02 it is 16% and for >0.04 it is 89%.
However, on reflection I can make the following observations about
my husbands level of 0.02:
1. The surgeon did say that he did a particularly careful nerve sparing procedure due to my husbands (and my) age and the biopsy and MRI reports which showed an a very tiny bit of cancer. Maybe he left more tissue behind than he normally would causing a trace PSA to register.
2. The actual test is maybe reporting a higher PSA than normal - evidenced by 6 other people using the same lab within the last month or two moving from <0.01 to 0.01
3. Maybe my husband is one of these people who secrete a small amount of non-prostate PSA
4. Maybe, he hasn't reached a nadir at 6 weeks post RP
There is an 84% chance that the reason for the 0.02 is 1, 2 or 3 of the above. That is something to celebrate!! And there is a chance that he has not even reached this nadir yet so the probabilities are even better.
We should be able to work this out shortly with his next PSA test in three months.
Husband's age: 52. Sydney Australia.
Family history: Mat. grandfather died of PC at 72. Mat. uncle died of PC at 60. He has hereditary PC.
PSA: Aug07 - 2.5|Feb08 - 1.7|Oct09 - 3.67 (free PSA 27%)|Feb10 - 4.03 (free PSA 31%) |Jun10 - 2.69. DRE normal.
Biopsy 28Apr10: negative for a diagnosis of PC however 3 focal ASAPs “atypical, suspicious but not diagnostic” for PC. Review of biopsy by experienced pathologist, 1/12 core: 10% 3+3 (left transitional), 1/12 core: ASAP (left apex)
Nerve sparing RP, 20Aug10 with Dr Stricker. Post-op path: 3+4 (ISUP 2005). Neg margins, seminal vesicles, extraprostatic extension. Multifocal, with involvement in the peripheral, apex, fibro-muscular and transitional zones.
Post RP PSA, Sep10 – 0.02
Post Edited (An38) : 10/12/2010 1:25:31 AM (GMT-6)