prostate cancer that has spread to bone

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thankfuljen07
New Member


Date Joined Sep 2010
Total Posts : 1
   Posted 9/20/2010 6:06 PM (GMT -6)   
My husband has prostate cancer that has metesized to bones...His gleason is 8.
He has taken the hormone treatment and now is has quit working...He took 2 shots, one every 4 months...He found this out last Aug.  They couldn't operate since it had gotten into bones,pelvis and furmors...He has taken 10 radations treatments for pain.  His pain is gone .  They have started him on ketoconazole 200 mg three times a day plus prednisone l0 mg once a day.  They are keeping him on the hormone shot because it treats the whole body.  We would like to hear from someone that has gone thru prostate cancer that they can't operate on and let us know what to expect.  Everyone we know they could operate on...We are trying to take one day at a time...My husband will be 70 Lord Willing Oct.  Would love to hear from you. Thanks Jenny 

BillyMac
Veteran Member


Date Joined Feb 2008
Total Posts : 1858
   Posted 9/20/2010 6:28 PM (GMT -6)   
Sorry to hear about your husband Jenny but you have come to a great place for help from people who have trod the same road. Apart from the great members here you will find a great many treatment stories on YANANOW (a similar site) all of which are cataloged by age or PSA or gleason. Once the tumour has escaped the prostate to your husbands extent there is no benefit in subjecting him to surgery so his docs have adopted his current treatment.
Read some of the stories here:

www.yananow.net/Chart-Gleasonu6.htm#8

Bill
Biopsy

4 of 10 cores positive for Adenocarcinoma-------bummer!
Core 1 <5%, core 2----50%, core 3----60%, core 4----50%
Biopsy Pathologist's comment:
Gleason 4+3=7 (80% grade 4) Stage T2c
Neither extracapsular nor perineural invasion is identified
CT scan and Bone scan show no evidence of metastases
Da Vinci RP Aug 10th 2007

Post-op

Positive for perineural invasion and 1 small focal extension
Negative at surgical margins, negative node and negative vesicle involvement
Some 4+4=8 identified ........upgraded to Gleason 8
PSA Oct '07 <0.1 undetectable
PSA Jan '08 <0.1 undetectable
PSA April '08 <0.001 undetectable (disregarded due to lab "misreporting")
PSA August '08 <0.001 undetectable (disregarded due to lab "misreporting"-----it is not possible for any lab to get a reading of less than .003)

Post-op pathology rechecked by new lab:

Gleason downgraded to 4+3=7
Focal extension comprised of grade 3 cells
PSA September '08 <0.01 (new lab)
PSA February 09 <0.01
PSA May '10 <0.01

www.yananow.net/Mentors/BillM2.htm

Never underestimate old people ............ you don't get to be old by being stupid.

Purgatory
Elite Member


Date Joined Oct 2008
Total Posts : 25393
   Posted 9/20/2010 6:32 PM (GMT -6)   
Jenny,

I am so sorry to read of your husband's story. Sounds like a very advanced case. Do you know what his current PSA is at? There are several men here dealing with advanced pc, hopefully they will be able to advise you more. Please stay in touch and keep us posted.

David in SC
Age: 58, 56 dx, PSA: 7/07 5.8, 10/08 16.3
3rd Biopsy: 9/08 7 of 7 Positive, 40-90%, Gleason 4+3
open RP: 11/08, on catheters for 101 days
Path Rpt: Gleason 3+4, pT2c, 42g, 20% cancer, 1 pos marg
Incont & ED: None
Post Surgery PSA: 2/09 .05,5/09 .1, 6/09 .11. 8/09 .16
Post SRT PSA: 1/10 .12, 4/8 .04, 8/6 .06 11/10 ?
Latest: 6 Corr Surgeries to Bladder Neck, SP Catheter since 10/1/9, SRT 39 Sess/72 gy ended 11/09, on Catheter #21, will be having Ileal Conduit Surgery in Sept.

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 9/20/2010 6:43 PM (GMT -6)   
Hi Jen,
Keep the hope up. There can be good results. We have many members here that have done quite well for long periods of time with inoperable tumors. I would like to introduce you to a wonderful young man named David Emerson. He was diagnosed 5 years ago with lymphatic invasion and with bone Mets. He was 42 at the time and is doing very well at age 47. Here is a page he writes:

prostatecancerat42.blogspot.com

He is just one of many men who have endured long terms with metastatic prostate cancer. He has been through chemo, Ketoconazole, Nilandron, clinical trial, and is currently on DES. He also has been through spot radiation. If you write to him he will respond in kind.

You have to keep the faith that your husband will respond to the treatments. What he is being prescribed is fairly common given his circumstances. If it starts to fail there is still plenty that may work well.

Peace and love to you always...

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

60Michael
Veteran Member


Date Joined Jan 2009
Total Posts : 2243
   Posted 9/20/2010 8:20 PM (GMT -6)   
Jenny,
I cant add any more than the others already have, but thanks for being here and I hope that you and your husband will have many more years together.
Michael
Dx with PCA 12/08 2 out of 12 cores positive 4.5 psa
59 yo when diagnosed, 61 yo 2010
Robotic surgery 5/09 Atlanta, Ga
Catheter out after 10 days
Gleason upgraded to 3+5, volume less than 10%
2 pads per day, 1 depends but getting better,
 started ED tx 7/17, slow go
Post op dx of neuropathy
T2C left lateral and left posterior margins involved
3 months psa.01, 6 month psa.4, 6 1/2 month psa.5 on 11/28/10
Starting IMRT on 1/18/10, Completed 39 tx at 70 gys on 3/12/10
6 week Post IMRT PSA .44 a drop from .5 but maybe more
Great family and friends
Michael

English Alf
Veteran Member


Date Joined Oct 2009
Total Posts : 2218
   Posted 9/21/2010 2:00 AM (GMT -6)   
Jenny,

Welcome to you (and your husband) And sorry you have to be here.

All I can say is that today is my brother-in-law's 75th birthday (I live in Europe so in my timezone that's 21st September)

I don't see a lot of him these days, but he was diagnosed with PCa about 7 years ago, and it had already spread beyond the prostate and they couldn't operate. He had RT and is still here. He's enjoying life, and that's what really matters I think.

Alf
Born Jun ‘60
Apr 09 PSA 8.6
DRE neg
Biop 2 of 12 pos
Gleason 3+3
29 Jul 09 DaVinci AVL-NKI Amsterdam
6 Aug 09 Cath out
PostOp Gleason 3+4 Bladder neck & Left SVI -T3b
No perin’l No vasc invasion Clear margins
Dry at night
21 Sep 09 No pads daytime
17 Nov 09 PSA 0.1
17 Mar 10 PSA 0.4 sent to RT
13 Apr 10 CT
28 Apr 10 start RT 66Gy
11 Jun 10 end RT
Tired
BMs weird
14 Sep 10 PSA <0.1
Erections OK

zufus
Veteran Member


Date Joined Dec 2008
Total Posts : 3149
   Posted 9/21/2010 7:02 AM (GMT -6)   
Spend some time looking at www.hrpca.org  website, they have a yahoo groups for advanced patients that you might join, they have some answers as to what to expect and what else might be of some use. They can't predict exactly how long someone will live with known mets, it varies. There are things for bone integrity like Zometa, Fosamax, Adredia, Actonel. Radiations can be done to eleviate pain bones when directed to known hot spots, drugs can be used to control various pain issues. The Keto drug might work fairly well (that varies also as does all drug protocols). You might look into pre-plans (ahead) for hospice and such (this is jumping the gun per se). I am sure websites have info on how to handle going forward.
www.cancer.gov/cancertopics/pdq/supportivecare   (might be useful site for into to you)

Post Edited (zufus) : 9/21/2010 4:24:36 PM (GMT-6)


logoslidat
Veteran Member


Date Joined Sep 2009
Total Posts : 6079
   Posted 9/21/2010 11:11 AM (GMT -6)   
Jenny there are a significant amount of men in your husbands condition that live a long time with the proper protocals. If you haven't already, You need to find a oncologist that specializes in prostate cancer. U of Washington Seattle have them as do many major cancer centers. Sounsd like the treatment he has been getting is in the right direction but get some second opinions.
age 67 First psa 4/17/09 psa 8.3, 7/27/09 psa 8.1
8/12/09 biopsy 6 out of 12 pos 2-70%, rest <5% 3+3
10/19/09 open rrp U of Washington Medical Center, left bundle spared
10/30/09 catheter out. continent from the jump.
pathology- prostate confined, only thing positive was the report.everything else negative
9% of prostate affected. gleason 3+4, I suppose thats a negative
After reading pathology myself, gleason was 3+4 with tertiary 5, 2-3 foci, extensive PNI, That is a negative, but I am a positive !!
Ed an issue but keeping the blood flowing with the osbon pump
Dec 14,2009 psa 0.0 May 10 2010, psa 0.0

" Hypocrisy is vice's homage to Virtue " Francois de la Rochefoucauld, source courtesy of Tatt2
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