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Tim G
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Date Joined Jul 2006
Total Posts : 2275
   Posted 10/1/2010 9:25 PM (GMT -6)   
There's a new PSA test that has been developed for post-prostate surgery patients.  The standard and high-sensitivity tests now available measure PSA in nanograms (billionths of a gram).  The new PSA test (see blurb below) measures PSA in picograms (trillionth of a gram).  My question is do we need a test that is super sensitive? The anxiety index for post-prostatectomy patients is high enough already without adding to it with a test that is this sensitive.  Does it make any difference if a PSA result is 1 trillionth of a gram vs. 2 trillionths of a gram?
MedWire (9/30, Guy) reported that scientists at the Boston-based Quanterix Corporation "have developed a novel method to detect serum prostate-specific antigen (PSA) levels in men who have undergone surgery for prostate cancer." In fact, "in preliminary validation studies, the AccuPSA test -- which uses Single Molecule Array technology to separate individual PSA molecules and count them -- showed a lower detection limit of 0.01 pg/ml, and a quantification limit of less than 0.05 pg/ml. The assay also demonstrated good agreement with a standard PSA test when used to detect higher PSA levels

Post Edited (TimG) : 10/1/2010 9:38:33 PM (GMT-6)

Veteran Member

Date Joined Jul 2010
Total Posts : 3596
   Posted 10/1/2010 9:39 PM (GMT -6)   
Many surgeons use the standard test that reads undetectable at 0.0 Why put patients through all the worry as the ultra-sensitive readings float around? In the end, will it make any difference??

Veteran Member

Date Joined Apr 2008
Total Posts : 813
   Posted 10/2/2010 7:17 AM (GMT -6)   
Like a lot of other junk we see. I doubt we will ever see anything about this again.
Dx 42
Gleason 6 (tertiary score 0)

open RP 10/08 Johns Hopkins

pT2 Organ confined Gleason 6

10/15/2009 <.1
10/15/2010 <0.03
10/15/2011 -

Regular Member

Date Joined Mar 2010
Total Posts : 145
   Posted 10/2/2010 7:48 AM (GMT -6)   
Actually for high grade Gleason patients, it may make a difference. Many high grade tumors produce very low PSA so a low PSA score in these individuals may not necessarily be indicative of what is actually going on. I can see a potential use for this.
Dx June 2007 - age 48

davinci RRP October 2007
75% of prostate involved
Positive margin
Scans clear
No detectable mets
SRT - Feb 2008
At Dx: 8
Mar 09: 0.4
Jun 09: 0.7
Aug 09: 1.7
Feb 10: .008
Apr 10: .007
Jul 10: .006
Sep 10: .005

Commenced Dr. Robt Leibowitz "Three Pronged Approach" protocol in August 2009

Completed chemo Dec 28 2009
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