BIMIX QUESTION

New Topic Post Reply Printable Version
[ << Previous Thread | Next Thread >> ]

Woodworker
Regular Member


Date Joined Apr 2010
Total Posts : 90
   Posted 10/11/2010 3:16 PM (GMT -6)   
My uro has decided it would be a good idea for me to try some BIMIX.  They require a minimum of two office visits to confirm how well it works, make sure the dosage is right and teach you how to give yourself the shots. I have already had the first visit.  I was very pleased with the results. 
My question is, how much does BIMIX normally cost. I can't seem to be able to nail down that piece of information.  Any information about cost or anything else to do with the BIMIX would be appreciated.
Age : 56
Diagnosed 3/29/2010
5mg Cialis daily
PSA 2.7; Gleasen (3+4) Biopsy 2 cores of 12 25% positive
DaVinci surgery 6/25/2010
Returned to work: 7/12/2010
Post Surgery
Final Biopsy report
5 slides of 35 were 2% positive for cancer
Clear Margins
Final Gleason (3+4)
Incontinence: None
ED: 5mg Cialis Daily
Just started on BIMIX. First results were very good

julios
Regular Member


Date Joined Jun 2010
Total Posts : 38
   Posted 10/11/2010 4:10 PM (GMT -6)   
I pay $135 for 5ml of Trimix. Get the smallest quantity they will give you. It expires after 30 days. Typically you'll be allowed to use it not more than 3 times a week.

Good luck.
Age 52

At Diagnosis of PCa, had Gleason 9 and normal PSA

Radical Prostatectomy on July 7th, 2010 by Dr. Fagin using daVinci

25% to 50% nerves spared on left, 100% spared on right.

Continent from day one.

Pathology showed postive margins and extension beyond gland, including seminal vesicals and lymph nodes. Stage upgraded to T3b.

MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 10/11/2010 6:18 PM (GMT -6)   
Hi Wood,

It varies greatly by region and compounding pharmacy

I get a 5ml vial delivered packed in ice packs of Trimix for $64, 90 day expiration if kept refrigerated

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 10/11/2010 6:29 PM (GMT -6)   
I buy Bimix 30/1/10mcg, 5ml vial for $56. I think that's close to what Francks' in Florida charges also. My Trimix is $97 per 5ml vial. Both of these are from Medicine Shoppe Pharmacy. If you are lucky to have one that has their own compound lab, those prices should hold nationwide.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RRP, Path: pT2c, 110 gms., all clear except:
Probable microscopic involvement of the left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09- Uh-Oh
ED continues: Bimix .30cc & Trimix .15cc PRN

Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 10/12/2010 1:17 AM (GMT -6)   
Bimix is a relatively cheap option, so three times a week will not break the bank. Of course a lot depends on what dose you need, and you don't know that until you have done some trials.

My bimix had a nominal life of three months, but I found that my last batch kept refrigerated was still going well at nine months. To avoid contamination as much as possible, I would prepare 10 syringes at a time, and so avoid diving into the vial for every jab.

If you get erratic results, I strongly recommend some constriction at the time of injection and a few minutes after. I used a few office rubber bands doubled over and wrapped around the base -- there are equivalents.

Others in this forum have recommended a little pump-up beforehand, but I found that did nothing for me.
Pre-op:
Age 63 at diagnosis, now 65.
No symptoms; PSA 5.7; Gleason 4+5=9; cancer in 4 of 12 cores.
Operation:
Non-nerve-sparing open surgery on 7 March 2008.
Two nights in hospital; catheter out after 7 days.
Post-op:
Continent; no pads needed from the get-go.
Pathology showed organ confined and negative margins. Gleason downgraded to 4+4=8.
PSAs:
6-week : <0.05
7-month: <0.05
13-month: 0.07 (start of a trend?)
19-month: 0.09 (maybe)
25-month: 0.2 (yes, bummer)
27-month: 0.2 (not up; glad about that)
ED:
After a learning curve, Bimix injections (0.2ml) worked well. From 14 months, occasional nocturnal erections. At 18 months, "graduated" to just the pump.

MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 10/12/2010 4:02 AM (GMT -6)   
Hi Piano,

How do you fill 10 syringes without jabbing each into the vial, do your syringes come apart and the needle end stays in the vial ?

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 10/12/2010 8:34 AM (GMT -6)   
The vial is sealed with a metal ring that contains a rubber disk in the center, which is self sealing when inserting a needle into it. You just have to make sure that you clean the rubber disk properly with alcohol before each needle insertion, along with wiping the needles, even brand new one, with the alcohol. The rubber seal wil continue to reseal each puncture.
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RRP, Path: pT2c, 110 gms., all clear except:
Probable microscopic involvement of the left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09- Uh-Oh
ED continues: Bimix .30cc & Trimix .15cc PRN

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4119
   Posted 10/12/2010 9:02 AM (GMT -6)   
Piano, What is the advantage of filling the 10 at a time. If you keep the vile in the fridge just load them as you need then.

Waiting for your reply.

Cajun Jeff

Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 10/13/2010 4:53 AM (GMT -6)   
Corvetteman:
I found difficulty in exactly measuring the 0.2ml dose I was on, so preferred to do a bunch when I was wide awake and had good light. And I figured, (without any proof whatsoever!) that up to 10 vial insertions in sequence was cleaner than 10 insertions on separate occasions.

I used a special draw-up needle which is extra long and much coarser -- don't know if this is general practise. I did the draw, pulled the needle with syringe out of the vial, then replaced the draw-up needle on the syringe with the the real needle. I wanted the real needle to stay as sharp as possible, so avoided using it to puncture the seal on the vial. Then fitted the same draw-up needle to a fresh syringe and repeated.

And no, I never did screw up and use the draw-up needle for an actual injection smhair

Mr Gimpy:
My syringes were of the type that had a screw-in needle. It would have been possible to leave the draw-up needle inserted in the vial and just screw in each new syringe, but again I found it easier to remove the syringe completely from the vial to unscrew the needle, using the needle's protective cap.

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4119
   Posted 10/13/2010 6:54 AM (GMT -6)   
Thanks for the clairification. Did you get those syringes from your reg. pharmacy. That is an interesting concept and I do think the needle would be sharper and make an easier injectin.
 
Cajun Jeff

James C.
Veteran Member


Date Joined Aug 2007
Total Posts : 4463
   Posted 10/13/2010 4:02 PM (GMT -6)   
Piano, the thing that pops into my mind when reading your description of using screw off needles is the idea of the end of the needle, hence the inside of the vial and it's contents being exposed to room air and any 'unsterile' conditions while you are drawing up the drug , then making the transfer from big needle to putting on the smaller needle. It may well be a sterile fieled throughout, but I can't picture it. I imagine these little micro-bugs diving into the open end of the draw up syringe and into the vial, or into the to be used syringe. smilewinkgrin
James C. Age 63
Gonna Make Myself A Better Man tinyurl.com/28e8qcg
4/07: PSA 7.6, 7/07 Biopsy: 3 of 16 PCa, 5% involved, left lobe, GS6
9/07: Nerve Sparing open RRP, Path: pT2c, 110 gms., all clear except:
Probable microscopic involvement of the left apical margin -GS6
3 Years: PSA's .04 each test until 04/10-.06, 09/10-.09- Uh-Oh
ED continues: Bimix .30cc & Trimix .15cc PRN

Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 10/13/2010 4:04 PM (GMT -6)   
Corvetteman:
My syringes came from my ED clinic. They are BD 3ml Syringe with Luer-Lok (TM) tip. I have never heard of Luer-Lok either, but am sure it is the special screw tip. The matching needles are BD PrecisionGlide (TM), which come in various sizes. My draw-up needle was 22G x 1.5" long, and of course the real needle was a lot finer.

Each needle comes with a cap, which serves as both a protector and a wrench to screw/unscrew the needle/cap to/from the syringe. To remove the cap once the needle is screwed in is just a straight pull. I found the system easy to use, and would be happy to use it again.

Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 10/13/2010 4:49 PM (GMT -6)   
James:
I agree that leaving the large needle poked into the vial without a syringe body attached is a potential source of contamination, which is another reason not to do it. As I mentioned above, I didn't do it because of the difficulty of unscrewing the syringe body from draw-up needle, which being in the vial, could not have its cap/wrench attached.

And as you say, there is the exposure to air of syringe and contents while you are changing needles.

Even with a one-piece syringe I can still image those little buggies diving into the end of the needle after you have withdrawn it from the vial :-)

We will never have completely sterile conditions, so all we can do is our best, and not leave things uncapped or open for any longer than necessary. I survived! turn

Cajun Jeff
Veteran Member


Date Joined Mar 2009
Total Posts : 4119
   Posted 10/13/2010 5:49 PM (GMT -6)   
Piano I sent you an e-mail.

Cajun Jeff
9/08 PSA 5.4 referred to Urologist
9/08 Biopsy: GS 3+4=7 1 positive core in 12 1% cancer core
10/08 Nerve-Sparing open radicalSurgery Path Report Downgrade 3+3=6 GS Stage pT2c margins clea
r3 month: PSA <0.1
19th month: PSA <0.1
Only issue at this time is ED

MrGimpy
Veteran Member


Date Joined Jul 2009
Total Posts : 504
   Posted 10/13/2010 7:32 PM (GMT -6)   
Hi Piano,

Thanks for the detailed how to. Do you notice any diff when a needle did not lose its sharpness by being inserted into the vial ?

lifeguyd
Veteran Member


Date Joined Jul 2006
Total Posts : 686
   Posted 10/13/2010 8:53 PM (GMT -6)   
 
Whoa guys... tongue
 
You are making this sound way to complicated.  It is really rather simple.  When you and your sweety decide it is time for romance, smurf   you go to the refrigerator and fill a syringe and inject.  Total time ..maybe 3 minutes...then talk nice and you know ...magic happens.
 
I admit I am an old guy and it is only once or twice a week for us, but even if it is more often, it is not a major thing to fill and inject.
 
I have learned some things from this posting.  I have been shipped 10ml some of which does not get used before "super' expiration.  I can save a few bucks by buying 5ml.  When I say 'super expiration'  I mean that it has a 90 day use date but can go at least double that ..maybe more.. if kept cold.
 
 
I thought I might add for those new to injections.  I use .15 of Bimix and have for over three and 1/2 years. 

Post Edited (lifeguyd) : 10/13/2010 8:02:02 PM (GMT-6)


Piano
Veteran Member


Date Joined Apr 2008
Total Posts : 847
   Posted 10/14/2010 3:40 PM (GMT -6)   
Mr Gimpy:

The tops on my vials were quite tough, and on the one or two occasions I used a fine needle for the draw, it was a struggle, and the needle bent somewhat. I never did use that needle for the injection, so can't comment on the sharpness.

There must be a scientific way of measuring needle sharpness without sticking it you know where. E.g., measure the force necessary to poke it through a vial top.
New Topic Post Reply Printable Version
Forum Information
Currently it is Monday, September 24, 2018 7:11 AM (GMT -6)
There are a total of 3,006,008 posts in 329,292 threads.
View Active Threads


Who's Online
This forum has 161818 registered members. Please welcome our newest member, demonsss.
222 Guest(s), 3 Registered Member(s) are currently online.  Details
BangedUp, 3timechamp, Buddy Blank