Casey, are you saying that PCA increases in agressiveness over time? That a 3+3 becomes a 4+4 over time? That would make watchful waiting a silly exercise wouldnt it?
ChrisR.. So would be willing to get it 10 years earlier, if he could be assured of a less agreessive case..3+3. Interesting.
If I read this correct, Casey thinks it grows worse over time, so the later you get it the better, period?
(Not trying to put words in you mouths here guys).
We know that if you get it late enough in life, it likely wont have any impact.
I THINK THAT REALLY IS THE QUESTION, WOULD YOU RATHER BE 45 WITH A 3+3 OR 55 WITH A 4+4.
Bob, sorry, I pulled out my earlier posting (deleted it), added significantly to it with the link to the MSK web seminar, and reposted it a few minutes later...and your post above was apparently sent in between my postings. As luck would have it, I went back and flipped through this thread and saw your question back to me, which I will address here. Sorry for any confusion this might have caused.
I think I partially answered your question in the re-posted response. Here's the basic premise: someone who is 4+4 didn't start out as 4+4. Rather, their cancer progressed from a lower grade first. Not everyone's cancer grade progresses indeffinately, and the progression can be stopped or slowed in some people by diet, exercise and/or lifestyle changes, or other factors.
I would always want to have a less aggressive cancer that may or may not grow to be more aggressive, because there are levers within my control to help slow or stop the progression, as well as levers outside of my control which may prevent it from further progressing.
Bob, does this additional posting help clarify?