Add this article to the list of studies indicating favorable statistics from preemptive ART from The Journal Urology (2009) (sorry I can't find a full text link at this time):
Adjuvant Radiotherapy for Pathological T3N0M0 Prostate Cancer
Significantly Reduces Risk of Metastases and Improves Survival:
Long-Term Followup of a Randomized Clinical Trial
Ian M. Thompson,*,† Catherine M. Tangen, Jorge Paradelo, M. Scott Lucia,
Gary Miller,‡ Dean Troyer, Edward Messing, Jeffrey Forman, Joseph Chin,
Gregory Swanson, Edith Canby-Hagino and E. David Crawford
From the University of Texas Health Science Center at San Antonio (IMT, DT, GS) and Wilford Hall Medical Center (ECH), San Antonio, Texas, The Fred Hutchinson Cancer Research Center, Seattle, Washington (CMT), The Kansas City Community Clinical Oncology Program, Kansas City, Missouri (JP), The University of Colorado Health Science Center, Denver, Colorado (MSL, GM, EDC), The James P. Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, New York (EM), Wayne State University School of Medicine, Detroit, Michigan (JF), and the University of Western Ontario, Department of Surgical Oncology, London, Ontario (JC)
Purpose: Extraprostatic disease will be manifest in a third of men after radical
prostatectomy. We present the long-term followup of a randomized clinical trial
of radiotherapy to reduce the risk of subsequent metastatic disease and death.
Materials and Methods: A total of 431 men with pT3N0M0 prostate cancer were
randomized to 60 to 64 Gy adjuvant radiotherapy or observation. The primary
study end point was metastasis-free survival.
Results: Of 425 eligible men 211 were randomized to observation and 214 to
adjuvant radiation. Of those men under observation 70 ultimately received radiotherapy.
Metastasis-free survival was significantly greater with radiotherapy
(93 of 214 events on the radiotherapy arm vs 114 of 211 events on observation;
HR 0.71; 95% CI 0.54, 0.94; p 5 0.016). Survival improved significantly with
adjuvant radiation (88 deaths of 214 on the radiotherapy arm vs 110 deaths of
211 on observation; HR 0.72; 95% CI 0.55, 0.96; p 5 0.023).
Conclusions: Adjuvant radiotherapy after radical prostatectomy for a man with
pT3N0M0 prostate cancer significantly reduces the risk of metastasis and increases
PSA 1.5 to 3.2 in 11 months. First 12 core biopsy on 2/10 negative in 11, atypical in 1. Second 13 core biopsy on 5/10 at Hopkins positive in 2 with Gleason 3+3 (focal). Robotic "Super VIP" Mani Menon on 8/10. Postoperative Gleason 3+4 (70%/30%). Focal ECE right posteriolateral mid. Negative margins, lymphs, seminal vesicles. First PSA on 9/14 <.1. Never incontinence +ED