New chemo JEVTANA

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ahiinc
Regular Member


Date Joined Aug 2010
Total Posts : 23
   Posted 11/12/2010 11:40 AM (GMT -6)   
I am looking for anyone who is currently being treated with the newly released chemo JEVTANA (cabazitaxel) or anyone who went through the clinical trial.
stevec

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 11/12/2010 11:44 AM (GMT -6)   
I have no experience with the drug but I did have Sanofi-aventis at my UsTOO group last month to talk about it. They're calling the first 2nd line chemotherapy drug. This suggests that you will be starting with Taxotere and then later Cabazataxel. My oncologist also spoke about it as well at our group and indicated that it is indeed more effective than just Taxotere. I am still awaiting someone to come here with the experience but I know a few men considering it.

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

ahiinc
Regular Member


Date Joined Aug 2010
Total Posts : 23
   Posted 11/13/2010 9:40 AM (GMT -6)   
I had been treated with Taxotere from April 2010 till August 2010, (though the treatment did not give the results we needed, tumor continued to grow).  I went through Radiation for 3 weeks to manage the pain which did help some.  I started this newly released Jevtana 4 weeks ago (received my second injection Tuesday).  The side effects are far more intense than the side effects from the Taxotere.   I have not spoken/communicated with anyone who is receiving the treatment locally or otherwise.  I am told by my oncologist I am his and the local Cleveland Clinics only Jevtana patient.  I was hoping to find a source for patients who may have been through the clinical trial or at least going through the treatment with me to compare notes.
 
Diagnosed 2005 PSA 35 Gleason 4.5 + 4.5 =9  (Prostate removed and started Homone treatments)
4/2010 found tumor 3.5" in abdomen. (low PSA but rapid growth).  Chemo started
8/2010 Radiation for 3 weeks
10/2010 Jevtana chemo and radiation (cancer has spreadinto the hip and leg bones)

Shad
New Member


Date Joined Apr 2009
Total Posts : 5
   Posted 11/13/2010 2:51 PM (GMT -6)   
Like you I am a Gleason 9. I was diagnosed in 2007. I have had taxotere, novatrane and most recently Jevtana. I am in Cincinnati so we are both from Ohio and also like you I was the first one here to try this drug. I had 4 infusions.

On the good side, the drug immediately reduced the pain in my spine. I reduced on my own the amount of my pain meds. The bad news was that it killed my white blood cells. This left me feeling pretty bad. The worst was the second week. But by the 4th infusion the length of time I felt bad had increased. The CT scan showed some areas of success with the drug but the tumors in my liver continued to grow too fast.

So after consulting with my oncologist I decided to stop the treatment. I hope you do not have the bad feeling I did. I am glad I did the drug and I could have continued. I just wanted to really enjoy the holidays and I felt it was time.

You should know that you can get a shot to counter the drop in white blood cells. You must get the shot within 24 hours and 72 hours of the infusion. I did not react well to the shot. But I react badly to lots of things so you will probably do better than I did.

Good luck to you.

Don

Tony Crispino
Veteran Member


Date Joined Dec 2006
Total Posts : 8128
   Posted 11/13/2010 3:05 PM (GMT -6)   
Don,
I can easily understand the desire to take a break during the holidays. I am sorry you both are dealing with this. But we are pulling for you and hoping for success with your treatments.

May peace be with you both during these holidays and always.

Tony
Disease:
Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

Treatments:
RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

Status:
"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog : www.caringbridge.org/visit/tonycrispino

Shad
New Member


Date Joined Apr 2009
Total Posts : 5
   Posted 11/13/2010 3:22 PM (GMT -6)   
Tony,

Thank you.

Don

ahiinc
Regular Member


Date Joined Aug 2010
Total Posts : 23
   Posted 11/14/2010 11:44 AM (GMT -6)   
Don,
Thanks for sharing that with me.  I have had no idea what to expect and finding some one else who could relate to the treatment and prognosis I beleive will be helpful to me.  I've found that the treatment knocked me down hard (typically 4 to 5 days following the treatment).  Every bone in my body aches and I sleep about 18 hours a day.  I do return the day after treatment for a white cell booster.  I've only had two infusions and don't yet beleive I am seeing any benifit.  My biggest issue now is the pain in my legs from the cancer in my hips and bones.  I am currently getting radiation in my leg and hope between the two to feel better before the holidays.
Best of luck and please stay in touch
stevec

Willie B
Regular Member


Date Joined Jul 2010
Total Posts : 155
   Posted 11/14/2010 4:53 PM (GMT -6)   
Thankyou for your input Stevec and Don.

I am on the cusp of having to decide about chemo, not sure I want to go that route with my prognosis.

I appreciate reading anything/everything about the chemo before committing to it.

Very brave of you to take this stuff, thanks again.

Shad
New Member


Date Joined Apr 2009
Total Posts : 5
   Posted 11/14/2010 9:40 PM (GMT -6)   
Stevec,

Feel free to email me anytime. My email address should be available under members.

I had CT scans before starting Jevtana and after fourth infusion. So I had hard evidence before deciding not to continue treatment.

Also my PSA rose after first infusion but came down more than it rose after the second infusion. I do not if that is normal but you mention that you are not sure about the benefit. It appears I did better after second infusion. Maybe you will, too.

Good luck,

Don

ahiinc
Regular Member


Date Joined Aug 2010
Total Posts : 23
   Posted 11/15/2010 10:14 AM (GMT -6)   
Willie B
I really struggled over my decision to go forward with chemo as well. It will change the quality of your life at least for a short time. I took a risk that the benifits would far out-weigh the down-side of treatment. The best of luck with your treatment decision. I have children at home and every decision I make is for them.
Steve
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