It is possible my PSA is increasing THIS fast?

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Regular Member

Date Joined Jun 2010
Total Posts : 416
   Posted 11/19/2010 12:34 PM (GMT -6)   
Hi Folks..
My 1st post-op psa was <0.10 on Aug 18 - undetectable is how they described it.
My 2nd post-op psa, blood taken Nov 9 - ultra sensitive machine, was 0.13.
Visited my uro in Boston - gave blood for another psa test Nov 16, just came back at .20.
Boston nurse says "there are different machines, variables, etc.
Even taking that into account, I though this test was determined to be pretty accurate?
I guess the BIG question to me is IS IT POSSIBLE TO GO FROM .13 TO .20 IN A SINGLE WEEK?
Thanks in advance, and happy holiday, if you can.

Veteran Member

Date Joined Nov 2009
Total Posts : 7187
   Posted 11/19/2010 1:10 PM (GMT -6)   
That seems very unusual.
I hate to say this, but I guess you could get yet another PSA in a week and see what happens

Regular Member

Date Joined Jun 2010
Total Posts : 416
   Posted 11/19/2010 1:17 PM (GMT -6)   
Thanks Mel... I just connected with my rad onc, he speeded up our end of mo appt for this coming tues.. so that will be 3 tuesdays in a row having psa test. That's about $150 retail cost. Nothing when compared to the $75k-$100k+k radiation plan i'm about to be on. Or the $30,000+- RRP.

Heck, the psa testing is the easiest part of all of this.. it's the results that seem to sting.

Tony Crispino
Veteran Member

Date Joined Dec 2006
Total Posts : 8128
   Posted 11/19/2010 1:21 PM (GMT -6)   
You need to read today's post on the InfoLink...

Advanced Prostate Cancer at age 44 (I am 48 now)
pT3b,N0,Mx (original PSA was 19.8) EPE, PM, SVI. Gleason 4+3=7

RALP ~ 2/17/2007 at the City of Hope near Los Angeles.
Adjuvant Radiation Therapy ~ IMRT Completed 8/07
Adjuvant Hormone Therapy ~ 28 months on Casodex and Lupron.

"I beat up this disease and took its lunch money! I am in remission."
I am currently not being treated, but I do have regular oncology visits.
I am the president of an UsTOO chapter in Las Vegas

Blog :

Worried Guy
Veteran Member

Date Joined Jul 2009
Total Posts : 3729
   Posted 11/19/2010 1:21 PM (GMT -6)   
In my opinion that is too high a value to ignore. If those were my numbers I'd be asking for copies the lab reports. That will tell you what machine and protocol was used. See if they are the same machine and if the values really were to 2 decimals. Two readings at 0.2 is generally considered a recurrence. The earlier you get it, the better.
How soon can you get your next PSA and appointment?

FYI here are my post DaVinci numbers:
I am in a study comparing the older ultra sensitive 2 decimal protocol (2006) with the new, more selective method (2010)
As you can see the older method reports a slightly higher value and my results are quite stable.

1/14 6 months - 0.05 (Siemens Centaur)
4/14 9 months - 0.04 (Siemens Centaur) and <0.01 (Roche ECLIA).
7/12 1 year - 0.03 (Siemens Centaur, direct chemilum); <0.01 (Roche Cobas 601 ECLIA)
10/22 15 months- 0.03 (Siemens Centaur, direct chemilum); <0.01 (Roche Cobas 601 ECLIA)

Personally if my Roche Cobas result ever gets above 0.05, I'll be on it so fast it will make my pee pad spin.

Good luck to you.

Post Edited (Worried Guy) : 11/19/2010 12:37:47 PM (GMT-7)

Veteran Member

Date Joined Jul 2010
Total Posts : 3595
   Posted 11/19/2010 1:23 PM (GMT -6)   
Sometimes these ultra-sensitive PSA tests, especially when done on different equipment by different labs, can cause a lot of needless PSA anxiety..

If we all had PSA tests every week, we would all be in insane asylums..
Age 68.
PSA at age 55: 3.5, DRE normal. Advice, "Keep an eye on it".
age 58: 4.5
" 61: 5.2
" 64: 7.5, DRE "Abnormal"
" 65: 8.5, " normal", biopsy, 12 core, negative...
" 66 9.0 "normal", 2ed biopsy, negative, BPH, Proscar
" 67 4.5 DRE "normal"
" 68 7.0 third biopsy positive, 4 out of 12, G-6,7, 9
RRP Sept 3 2010, pos margin, one pos vesicle nodes neg. Post Op PSA 0.9 SRT, HT, Dec

Veteran Member

Date Joined Jul 2008
Total Posts : 966
   Posted 11/19/2010 1:30 PM (GMT -6)   
Didn't someone post here about sending his blood sample through the mail and got a result of 0.6

Certainly caused him some anxiety to say the least.

It has always been recommended that the same lab be used for followup blood work due to just this very reason.

Get another test at the original lab before getting too excited about the numbers.
You are beating back cancer, so hold your head up with dignity


Signature details in Sticky Post above - page 2

Veteran Member

Date Joined Apr 2008
Total Posts : 847
   Posted 11/19/2010 1:31 PM (GMT -6)   
A big jump in a week is quite possible. Our PSA fluctuates from day to day, and of course, as your nurse said, there are variations within the lab and between labs. Unfortunately the simplest explanation is the best -- your PSA really is rising and the rise can be somewhat lumpy.

The key point to take from all this is your PSA has doubled in three months.

English Alf
Veteran Member

Date Joined Oct 2009
Total Posts : 2208
   Posted 11/19/2010 1:36 PM (GMT -6)   
No an easy thing to work out. But labs differ. Continuity helps.
My uro (and those of others here) insist on just the one lab doing all the tests.

I agree with the suggestion of getting a repeat from the same lab first.


Regular Member

Date Joined Jun 2010
Total Posts : 416
   Posted 11/19/2010 1:48 PM (GMT -6)   
Hello again everyone, and thank you. I certainly DO NOT intend to ignore these numbers.. I have rearranged my rad onc appt from the 29th to next tuesday. It's just that YOU folks can be such an immediate and helpful resources, that I also OBVIOUSLY had to see what the collective experience here might be.

For clarification:
The Aug 18 <0.10 was done at Cape Cod Hospital - in house.
The Nov 09 0.13 was sent out to ultra Ssensitive lab - "results pending" for 3+ days.
The Nov 16 0.20 was done at Boston Medical Center.

My uro at BMC had already convinced me to accept radiation (to be done back at Cape Cod Hospital) during our tuesday appt, prior to either of us knowing the latest 0.20 result.

Veteran Member

Date Joined Feb 2010
Total Posts : 3771
   Posted 11/19/2010 3:01 PM (GMT -6)   
very wise decision, Bob.  i wish the very best for you.
age: 55
PSA on 12/09: 6.8
no symptoms, no prostate enlargement
12/12 cores positive....gleason 3+4 = 7
received 3rd and last lupron shot 9/14/10
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