A new drug to watch, always have hope

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Regular Member

Date Joined Apr 2008
Total Posts : 364
   Posted 11/21/2010 9:19 AM (GMT -6)   
It's early but it sure looks promising.

In very early testing, 19 of 20 patients showed an improvement in the scans used to determine whether cancer has spread to the bone. In some cases, the bone scans could no longer detect any cancer, and the men were able to stop taking the narcotics they were using to control bone pain. To be sure, the results are from very few patients and there was no control group. It is still not known if XL184 prolongs life or how long the improvement in bone scans will last.

“There’s really no precedent for another drug that does this,” said Dr. Matthew R. Smith, a prostate cancer specialist at theMassachusetts General Hospital.

Also, bone scans actually measure bone formation, not the presence of cancer itself. So it cannot be completely ruled out that XL184 somehow stopped bone growth without killing the cancer. However, Dr. Smith said he doubted that was the case because there were signs the drug also controlled tumors outside the bones.

Drugs now used to treat advanced prostate cancer, like Taxotere, do not have much affect on bone scans, Dr. Smith said. Bone drugs like Zometa from Novartis and denosumab from Amgen can protect cancerous bones from fractures, but have not been shown to fight the cancer itself.

Another investigator in the trial, Dr. David C. Smith of the University of Michigan, said he could not believe it when the bone scan of one patient, who previously had widespread cancer in his bones, came back completely clean.

“I thought they had scanned the wrong person,” said Dr. Smith, who is not related to the doctor in Massachusetts. “I’ve never seen anything like this.”



Regular Member

Date Joined Aug 2009
Total Posts : 284
   Posted 11/21/2010 10:54 AM (GMT -6)   
Thanks for posting David. I read a bit more after this and seems the side effects so far aren't extreme. My worry about bone pain following bone metastases is probably more than concern about my demise from Pca. This hopeful step in reducing metastases (and pain) gives me hope for the future.

Take care,
Dx 8/08 Pre-op psa 4.2, Age 60, 7 of 12 biopsies positive 3+3
DaVinci LRP 11/08, clear margins, - EPE, vascular or perineural. Gleason 3+4=7, 5-10% of 4.
3 month psa .1 2/09, 6 month .1 5/09, 9 month .2 8/09
broke ankle bones 6/09
9/21/09 Bone scan clear, psa still .2
01/05/10 psa .3, SRT 01/19/10 start 39 sessions 70.2gy, psa @ 6 weeks into IMRT .4
Post SRT psa @ 10 weeks (5/31/2010) .2, @20 weeks (8/20/10) .1 (getting close)

Veteran Member

Date Joined Oct 2006
Total Posts : 1210
   Posted 11/21/2010 5:19 PM (GMT -6)   
Hi David.
Thanks for this `heads up` and a new glimmer of hope for those with
advanced Pca. It would really be a God send if the promise of this drug would
hold true. Unfortunately, most of  us here have heard or read about similar
weapons against Pca, but it always turned out to be empty anticipation. We can
only hope that one of these drugs will eventually turn out to be really
effective. We will always hope, because that is what keeps many of us
All the best to you and have a great holiday season.

Born 1936
PSA 7.9, Gleason Score 3+4=7, 2 of 8 positive
open RP Nov 06, T3a, Gleasons 3+4=7, Seminal vesicles and lymph nodes clear
Catheter out 15 Dec 06, Dry since 11 Feb 07
All PSA tests in 2007 (4) <.04
PSA tests in 2008: Mar.=.04; Jun.=.05; Sept.=.08; at SRT Start=0.1, Salvage RT completed (33 days-66Gy) 19 Dec 08
PSA: in Jan 09 =.05, all tests to date (Jul 10) <.04

Regular Member

Date Joined Jun 2010
Total Posts : 416
   Posted 11/22/2010 7:21 AM (GMT -6)   
I was discussing this drug with a buddy last week.. that day the stock of the company that makes XL184 went up 32%. I figured those are votes of the wallet, not of hope. Some of the numbers/results are just too overwhelming to ignore "In a cohort of patients with prostate cancer, 95% of patients achieved complete or partial resolution of metastatic bone lesions".

I remember thinking that these are legit doctors and that this drug clearly made SOMETHING happen. When you look at these results and then the provenge 4+- month gain in survival, there certainly seems to be reason to have hope. I'm sure 19 of these 20 people have reason to.. when ANY good news can be rare.

I would like to see some more "URGENCY" in the effort to find a cure for this nasty disease! Yes, this is important for those who are most advanced, but we should be trying to stop this killer BEFORE it gets that that extreme.

When doctors say "if I had to have a cancer it would be prostate"... that kinda makes people think of it as cancer-lite. Trust me, when they carved the prostate out of me, and when I tried peeing or having an erection without one, it didn't feel like "lite" to me.

And now as I am 6 months out from that nightmare, my psa goes from undetectable to .13 to .20.. I'D REALLY RATHER NOT HAVE TO WAIT UNTIL SUCCESS IS MEASURED BY HOW MUCH CANCER THEY CAN GET OUT OF MY BONES.

Sorry for ranting.
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